Neue Studien: Europe PMChttps://www.psoriasis-news.de/articles.html/1_articles/page/23/?d=1Neue Studien: Europe PMCdePIEZO1 promotes psoriasis-like skin inflammation in mice via NF-κB/IL-17 signaling pathway activation.https://www.psoriasis-news.de/articles.html/1_articles/piezo1-promotes-psoriasis-like-skin-inflammation-in-mice-via-nf-%CE%BAbil-17-signaling-pathway-activation-r81/No abstract supplied.

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]]>81Sat, 14 Jun 2025 05:52:56 +0000Comorbid psoriasis in systemic lupus erythematosus: a cohort study from a tertiary referral centre and the National Patient Register in Sweden.https://www.psoriasis-news.de/articles.html/1_articles/comorbid-psoriasis-in-systemic-lupus-erythematosus-a-cohort-study-from-a-tertiary-referral-centre-and-the-national-patient-register-in-sweden-r80/ObjectivesTo investigate the prevalence of psoriasis in SLE using a Swedish regional cohort and a nationwide cohort from the National Patient Register (NPR). Furthermore, we compared clinical features between patients with and without comorbid psoriasis.

Methods

In total, 351 patients diagnosed with SLE based on the 1982 American College of Rheumatology and/or the 2012 Systemic Lupus International Collaborating Clinics criteria from Linköping University Hospital were evaluated. We obtained patient-reported and relevant clinical data extracted in 2024. Individuals with coexisting psoriasis were identified via the International Classification of Diseases code L40 and subsequent confirmation through chart review in the regional cohort. In the NPR, 7490 subjects with SLE living in Sweden in 2022 were identified, as well as therapies obtained from the Prescribed Drug Register.

Results

We identified 12 subjects with SLE and coexisting psoriasis (3.4%) in the regional cohort and 367 patients (4.9%) in the nationwide cohort. Men were proportionally more common in the group with comorbid psoriasis in both cohorts. Patients with psoriasis reported more pain on a visual analogue scale (median 45.5/100 mm, IQR 23.3-58.3) compared with those without coexisting psoriasis (median 27.0/100 mm, IQR 7.0-50.5, p<0.04). We observed no differences in damage accrual or clinical phenotypes between the two groups. Subjects with psoriasis were more frequently prescribed methotrexate in the nationwide cohort.

Conclusion

The prevalence of coexisting psoriasis in patients with SLE in Sweden was estimated to be 3.4-4.9%. Individuals with comorbid psoriasis reported more pain and were more likely to be prescribed methotrexate than those without psoriasis.

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]]>80Sat, 14 Jun 2025 05:52:56 +0000"Full-naïve" patients: the impact of previous methotrexate, cyclosporine, and acitretin on first-line biologics response in the treatment of moderate-to-severe psoriasis - a monocentric retrospective study.https://www.psoriasis-news.de/articles.html/1_articles/full-na%C3%AFve-patients-the-impact-of-previous-methotrexate-cyclosporine-and-acitretin-on-first-line-biologics-response-in-the-treatment-of-moderate-to-severe-psoriasis-a-monocentric-retrospective-study-r79/BackgroundThe impact of traditional systemic drugs to treat psoriasis (ciclosporin, methotrexate, and acitretin) in a subsequent response to biologics, has not been adequately addressed in the literature. In clinical practice it is increasingly necessary to initiate, due to concomitant comorbidities, biologics in patients with psoriasis or psoriatic arthritis (PsA) who have not undergone prior treatment with systemics, i.e. full-naive.

Objectives and methods

This study analyzed the possible impact of non-biological systemic therapies on the effectiveness and drug survival of first-line biologic drug up to 12 months in bio-naive psoriatic and PsA patients consecutively enrolled from January 2017 to March 2021.

Results

95 patients with severe psoriasis (13.5%) were full-naive. Being full-naive and having or not having undergone methotrexate or cyclosporine therapy did not impact response to subsequent years of biologic therapy. Only acitretin promotes faster response to subsequent biologic drugs with 59.6% and 74.2% of patients achieving Psoriasis Area Severity Index (PASI) 90 at 16 and 28 Week, respectively, vs. 50.5% and 65% (p = 0.034 and 0.026). In multivariate analysis, the advantage given by acitretin was lost.

Conclusion

Previous systemic therapy in bio-naive patients does not appear to result in a differential response to biologics during the first year of treatment.

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]]>79Sat, 14 Jun 2025 05:52:56 +0000Gender differences in psychological features and determinates of quality of life in axial spondyloarthritis and psoriatic arthritis: a cross-sectional study.https://www.psoriasis-news.de/articles.html/1_articles/gender-differences-in-psychological-features-and-determinates-of-quality-of-life-in-axial-spondyloarthritis-and-psoriatic-arthritis-a-cross-sectional-study-r78/BackgroundInvestigating gender-specific differences in rheumatology is crucial for improving personalized treatment. The present study aimed to explore gender differences in psychological characteristics and features associated with impaired physical and mental quality of life in male and female patients affected by axial spondyloarthritis or psoriatic arthritis.

Methods

The present study is cross-sectional. Quality of life was evaluated using a Medical Outcome Study 36-item Short Form health survey (SF-36), and physical and mental component scores were presented. Data about disease activity, anxiety and depression, fatigue, perceived stress, and coping strategies were collected. The patients were stratified by gender, and clinical and psychological data were compared.

Results

A total of 119 patients with axial spondyloarthritis [age 49.0 (SD 11.7); 45.4% F] and 198 patients with psoriatic arthritis [age 56.9 (SD 11.6); 62.6% F] were included. Female patients with axial spondyloarthritis and psoriatic arthritis had worse scores on fatigue, pain, perceived stress, physical quality of life, dysfunctional coping strategies, mental quality of life (only in axial spondyloarthritis), and anxiety (only in psoriatic arthritis) than men. In multivariable analysis, physical quality of life is mainly explained by fatigue and pain, and mental quality of life by fatigue, anxiety and stress in women with axial spondyloarthritis and psoriatic arthritis. Fatigue, pain and anxiety were significant variables across the models with male patients.

Conclusions

The study indicates that female patients with axial spondyloarthritis and psoriatic arthritis experience worse scores in psychological variables compared to men. Additionally, women's quality of life is significantly lower when compared to men's one, primarily due to factors such as fatigue, stress, pain, and anxiety. To enhance patient well-being, therapeutic strategies should be tailored to address the unique clinical and psychological needs that arise from gender differences.

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]]>78Sat, 14 Jun 2025 05:52:56 +0000Long-term air pollutants exposure on risk of psoriasis: the mediating role of accelerated biological aging among 284,544 participants.https://www.psoriasis-news.de/articles.html/1_articles/long-term-air-pollutants-exposure-on-risk-of-psoriasis-the-mediating-role-of-accelerated-biological-aging-among-284544-participants-r77/Weiterlesen

]]>77Sat, 14 Jun 2025 05:52:56 +0000The Association of Psoriasis and Bacterial Infections in Pediatric Patients: A Retrospective Review.https://www.psoriasis-news.de/articles.html/1_articles/the-association-of-psoriasis-and-bacterial-infections-in%C2%A0pediatric-patients-a-retrospective-review-r76/Background/objectivesGuttate psoriasis onset and plaque psoriasis flares are associated with streptococcal pharyngitis. Literature regarding the relationship between anogenital bacterial dermatitis and psoriasis in pediatric patients is limited. We aimed to evaluate the clinical characteristics, microbiology, and treatment course of patients with psoriasis/psoriasiform dermatitis and concomitant pharyngeal and/or anogenital bacterial infections.

Methods

A multicenter retrospective review of patients ≤ 18 years of age with psoriasis/psoriasiform dermatitis and bacterial infection, defined by positive culture results, was performed. Demographic characteristics, clinical features, microbiology, treatment recommendations, and outcomes were evaluated. Comparisons were made between pharyngeal and anogenital culture groups.

Results

A total of 166 unique patients with psoriasis/psoriasiform dermatitis and suspected pharyngeal and/or anogenital infection were evaluated between 2011 and 2021. Staphylococcus sp. and Streptococcus sp. were isolated in anogenital cultures. Inverse psoriasis was associated with a positive anogenital culture (p = 0.0356). Guttate psoriasis was more common in patients with a positive pharyngeal culture (p < 0.0001). Treatment of a positive bacterial culture did not correlate with the treatment response of psoriasis/psoriasiform dermatitis.

Conclusions

Investigations for anogenital and pharyngeal infections should be considered in pediatric patients presenting with new-onset or worsening psoriasis. A high clinical suspicion should be maintained for anogenital infection in patients with inverse psoriasis, specifically.

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]]>76Sat, 14 Jun 2025 05:52:56 +0000Exploring the association between relative fat mass and psoriasis risk: insights from the NHANES data.https://www.psoriasis-news.de/articles.html/1_articles/exploring-the-association-between-relative-fat-mass-and-psoriasis-risk-insights-from-the-nhanes-data-r75/BackgroundPatients' quality of life is greatly impacted by psoriasis, a prevalent chronic inflammatory skin condition that is frequently linked to a number of systemic disorders. Recent research shows that obesity is a major risk factor for psoriasis. Since Relative Fat Mass (RFM), an innovative way to measure obesity, offers a more precise estimate of body fat percentage, this study aims to investigate the connection between RFM and psoriasis and its potential as a disease predictor.

Methods

The analysis included 6,006 people the National Health and Nutrition Examination Survey (NHANES) conducted between 2003 and 2006, 151 of whom had psoriasis. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analysis, and interaction tests were employed to assess the link between RFM and psoriasis. ROC curves were used to compare RFM with conventional measures of obesity (WWI, BRI). Furthermore, LASSO regression and multivariable regression based on AIC were used to create a psoriasis risk prediction model that included RFM and additional clinical factors.

Results

RFM and psoriasis risk were revealed to be significantly positively correlated. The chance of developing psoriasis increased by 7% for every unit rise in RFM (95% CI: 1.03 to 1.12). RFM showed better predictive ability than conventional markers including BMI, WWI, and BRI (AUC = 0.573). The RFM-psoriasis relationship and diabetes status significantly interacted, with the association being weaker in diabetic individuals, according to subgroup analysis and interaction tests. Promising results were obtained from the created psoriasis risk prediction model that included RFM, age, total dietary sugar, education level, history of heart disease, and hypertension.

Conclusion

This research demonstrates that RFM outperforms traditional anthropometric methods in predicting risk. It also presents the initial evidence establishing a positive link between RFM and the likelihood of developing psoriasis.The psoriasis risk prediction model underscores RFM's effectiveness as a valuable approach in both clinical and public health domains, aiming to alleviate the impact of psoriasis-related issues by offering a practical instrument for early risk assessment and personalized clinical strategies.

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]]>75Sat, 14 Jun 2025 05:52:56 +0000Effects of Adalimumab on Mitochondria of Psoriatic Mesenchymal Stem Cellshttps://www.psoriasis-news.de/articles.html/1_articles/effects-of-adalimumab-on-mitochondria-of-psoriatic-mesenchymal-stem-cells-r74/No abstract supplied.

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]]>74Wed, 11 Jun 2025 06:56:28 +0000Understanding Psoriasis Patient Preferences for Biologic Dosing Frequencies: Insights From a Patient Surveyhttps://www.psoriasis-news.de/articles.html/1_articles/understanding-psoriasis-patient-preferences-for-biologic-dosing-frequencies-insights-from-a-patient-survey-r73/No abstract supplied.

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]]>73Sat, 07 Jun 2025 16:48:48 +0000Are psoriasis severity and comorbidities associated with diet quality? A cross-sectional analysis using UK Biobank.https://www.psoriasis-news.de/articles.html/1_articles/are-psoriasis-severity-and-comorbidities-associated-with-diet-quality-a-cross-sectional-analysis-using-uk-biobank-r72/Weiterlesen

]]>72Thu, 05 Jun 2025 13:21:39 +0000Immunoglobulin A vasculitis and pustular psoriasis precipitated by Tawon Liar: a case report.https://www.psoriasis-news.de/articles.html/1_articles/immunoglobulin-a-vasculitis-and-pustular-psoriasis-precipitated-by-tawon-liar-a-case-report-r71/Weiterlesen

]]>71Thu, 05 Jun 2025 13:21:39 +0000Effectiveness of Tildrakizumab 200 mg in Moderate-to-Severe Plaque Psoriasis: A Multicenter Real-World Study Analyzing Patient Outcomes by Weight, PASI, BMI, and Previous Therapies.https://www.psoriasis-news.de/articles.html/1_articles/effectiveness-of-tildrakizumab-200%C2%A0mg-in-moderate-to-severe-plaque-psoriasis-a-multicenter-real-world-study-analyzing-patient-outcomes-by-weight-pasi-bmi-and-previous-therapies-r70/IntroductionPsoriasis is a chronic immune-mediated disease with significant systemic implications. Tildrakizumab, an IL-23p19 inhibitor, has demonstrated efficacy in moderate-to-severe plaque psoriasis. Higher doses may be beneficial for patients with elevated body weight or greater disease burden. This study evaluates the effectiveness of tildrakizumab 200 mg in a real-world setting, analyzing outcomes based on weight, Psoriasis Area Severity Index (PASI), body mass index (BMI), and prior biologic exposure.

Methods

A multicenter retrospective study was conducted across 10 Italian hospitals. Adult patients (≥ 18 years) with moderate-to-severe plaque psoriasis treated with tildrakizumab 200 mg for ≥ 36 weeks were included. Patients were stratified by weight (≥ 90 kg vs. < 90 kg), BMI (≥ 30 vs. < 30), PASI (≥ 15 vs. < 15), and biologic history (naïve vs. biologic (bio)-experienced). PASI100 response rates at 36 weeks were assessed. Statistical analyses included Fisher's exact test (p < 0.05 significant).

Results

Among 137 patients, PASI100 response rates were 67.1% for patients < 90 kg vs. 49.2% for ≥ 90 kg (p = 0.04), 61.5% for PASI < 15 vs. 50% for PASI ≥ 15 (p = 0.03), and 60.8% for bio-naïve vs. 57.1% for bio-experienced (p = 0.08). BMI ≥ 30 was associated with lower PASI100 (44.2%) compared to BMI < 30 (61.4%) (p = 0.05). Despite subgroup differences, all patients exhibited clinical improvement.

Conclusion

Tildrakizumab 200 mg effectively treated moderate-to-severe psoriasis across diverse patient subgroups. While higher weight and PASI were associated with slightly lower PASI100 rates, significant improvements were observed, supporting its role in difficult-to-treat patients.

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]]>70Thu, 05 Jun 2025 13:21:39 +0000Multimodal Function of Mesenchymal Stem Cells in Psoriasis Treatment.https://www.psoriasis-news.de/articles.html/1_articles/multimodal-function-of-mesenchymal-stem-cells-in-psoriasis-treatment-r69/Weiterlesen

]]>69Thu, 05 Jun 2025 13:21:39 +0000Tratamiento tópico de la psoriasis: recomendaciones de expertos del Grupo Español de Psoriasis (GPS).https://www.psoriasis-news.de/articles.html/1_articles/tratamiento-t%C3%B3pico-de-la-psoriasis-recomendaciones-de-expertos-del-grupo-espa%C3%B1ol-de-psoriasis-gps-r68/Weiterlesen

]]>68Thu, 05 Jun 2025 13:21:39 +0000Deucravacitinib in Patients with Plaque Psoriasis Who Screened Positive for Psoriatic Arthritis: Improvements in Joint Pain and the Impact of Musculoskeletal Symptoms.https://www.psoriasis-news.de/articles.html/1_articles/deucravacitinib-in-patients-with-plaque-psoriasis-who-screened-positive-for-psoriatic-arthritis-improvements-in-joint-pain-and-the-impact-of-musculoskeletal-symptoms-r67/Weiterlesen

]]>67Thu, 05 Jun 2025 13:21:39 +0000Long term outcomes among patients with pre-existing psoriasis undergoing immune checkpoint inhibitor therapy: a case series and literature reviewhttps://www.psoriasis-news.de/articles.html/1_articles/long-term-outcomes-among-patients-with-pre-existing-psoriasis-undergoing-immune-checkpoint-inhibitor-therapy-a-case-series-and-literature-review-r66/Psoriasiform adverse cutaneous reactions to immune checkpoint inhibitor (ICI) therapy for cancer are potentially treatment-limiting. Few studies have investigated long-term outcomes related to exacerbations of pre-existing psoriasis and their impact on the efficacy of cancer treatment. Understanding outcomes in patients with autoimmune disease is important to guide management of these reactions and avoid unnecessary exclusion from ICI therapy. We conducted a retrospective cohort study using the University of Kansas Cancer Center database. We identified 20 adult patients with pre-existing psoriasis who were treated with ICIs between 2013 and 2022 and had at least one year of follow-up. Of these, 15 experienced exacerbation of their psoriasis during ICI therapy. Patients with exacerbation completed a higher median number of ICI cycles than those with unaffected psoriasis (16 vs. 9 cycles). Rates of ICI discontinuation due to side effects were similar between the two groups (26% vs. 20%). Kaplan-Meier analysis showed that patients with psoriasis exacerbation had significantly better progression-free survival compared to unaffected patients (p = 0.015). Although overall mortality was lower in the exacerbation group (40% vs. 60%), this difference was not statistically significant. Two patients with severe flares discontinued ICIs and initiated systemic therapy for psoriasis. One continued to show tumor remission, while the other maintained stable tumor burden, highlighting the variability and chronicity of flare responses. Overall, ICIs appear to be tolerable in patients with pre-existing psoriasis. Despite the high rate of exacerbation, most flares were mild and manageable with topical therapy, and most patients were able to complete their treatment. The comparable discontinuation rates and greater number of ICI cycles among those with flares suggest that psoriasis exacerbation does not necessarily impede cancer therapy. These findings support the inclusion of patients with psoriasis in ICI treatment protocols and suggest that cutaneous irAEs may be associated with improved therapeutic outcomes. Although limited by small sample size and retrospective design, this study contributes to the growing body of evidence supporting safe ICI use in patients with pre-existing autoimmune skin disease.

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]]>66Thu, 05 Jun 2025 13:21:39 +0000Practical Recommendations on Cardiovascular Risk Evaluation in Patients With Psoriasis and Psoriatic Arthritis for Dermatologists, Rheumatologists, and Primary Care Physicians by the Psoriasis and Psoriatic Arthritis Clinics Multicenter Advancement Networhttps://www.psoriasis-news.de/articles.html/1_articles/practical-recommendations-on-cardiovascular-risk-evaluation-in-patients-with-psoriasis-and-psoriatic-arthritis-for-dermatologists-rheumatologists-and-primary-care-physicians-by-the-psoriasis-and-psoriatic-arthritis-clinics-multicenter-advancement-network-r65/No abstract supplied.

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]]>65Thu, 05 Jun 2025 13:21:39 +0000All-Cause Mortality is Higher in Generalized Pustular Psoriasis (GPP) than Plaque Psoriasis and the General Population: A US-Based Claims Analysishttps://www.psoriasis-news.de/articles.html/1_articles/all-cause-mortality-is-higher-in-generalized-pustular-psoriasis-gpp-than-plaque-psoriasis-and-the-general-population-a-us-based-claims-analysis-r64/No abstract supplied.

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]]>64Thu, 05 Jun 2025 13:21:39 +0000Unraveling Psoriasis Flare-up and Dengue Infectionhttps://www.psoriasis-news.de/articles.html/1_articles/unraveling-psoriasis-flare-up-and-dengue-infection-r63/No abstract supplied.

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]]>63Thu, 05 Jun 2025 13:21:39 +0000Prevalence of Psychiatric and Addictive Disorders in Patients with Psoriasis: A Cross-Sectional Study.https://www.psoriasis-news.de/articles.html/1_articles/prevalence-of-psychiatric-and-addictive-disorders-in-patients-with-psoriasis-a-cross-sectional-study-r61/Background/Objectives: Psoriasis is a chronic inflammatory skin disease increasingly linked to psychiatric and behavioral comorbidities, including depression, anxiety, and substance use disorders. Shared inflammatory pathways, including elevated IL-6, TNF-α, and IL-17, may link psoriasis with psychiatric disorders such as depression and anxiety. The bidirectional interaction between systemic inflammation and mental health may exacerbate the disease burden and affect treatment outcomes. The objective of this study was to determine the prevalence of psychiatric and behavioral comorbidities in patients with psoriasis and to explore potential demographic and clinical correlations. Assessing these correlations contributes to a better understanding of the mental health status of psoriasis patients, potentially influencing both therapeutic efficacy and quality of life. Methods: We conducted a cross-sectional observational study on 316 patients with clinically and histopathologically confirmed psoriasis, evaluated between January 2021 and March 2025 at the Clinical Railway Hospital in Iași, Romania. Psychiatric and behavioral comorbidities were assessed through clinical interviews, medical record reviews, and standardized tools including AUDIT-C, Fagerström Test for Nicotine Dependence, and the Binge Eating Scale. Psoriasis severity was evaluated using the Psoriasis Area and Severity Index (PASI). Results: Of 316 participants, 88 (27.8%) had psychiatric/behavioral comorbidities. The most frequent conditions were tobacco use disorder (11.1% overall; 39.8% among comorbid patients), alcohol use disorder (9.2%; 32.9%), binge eating (7.9%; 28.4%), anxiety (6.3%; 22.7%), and depression (4.1%; 14.8%). Additional diagnoses included personality disorders, dementia, PTSD, and sleep disorders. Conclusions: Psychiatric and behavioral comorbidities, particularly substance use disorders, are relatively common in patients with psoriasis. These findings support the need for regular mental health screening and integrated care approaches in psoriasis management.

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]]>61Sun, 01 Jun 2025 05:56:38 +0000Myeloid PGGT1B Deficiency Promotes Psoriasiform Dermatitis by Promoting the Secretion of Inflammatory Factors.https://www.psoriasis-news.de/articles.html/1_articles/myeloid-pggt1b-deficiency-promotes-psoriasiform-dermatitis-by-promoting-the-secretion-of-inflammatory-factors-r60/Weiterlesen

]]>60Sun, 01 Jun 2025 05:56:38 +0000Novel ribosome biogenesis-related biomarkers and therapeutic targets identified in psoriasis.https://www.psoriasis-news.de/articles.html/1_articles/novel-ribosome-biogenesis-related-biomarkers-and-therapeutic-targets-identified-in-psoriasis-r59/Weiterlesen

]]>59Sun, 01 Jun 2025 05:56:38 +0000Treatment with spesolimab in patients with generalized pustular psoriasis: A review of real-world experience.https://www.psoriasis-news.de/articles.html/1_articles/treatment-with-spesolimab-in-patients-with-generalized-pustular-psoriasis-a-review-of-real-world-experience-r58/Weiterlesen

]]>58Sat, 31 May 2025 17:47:51 +0000Oral Peptide Therapeutics as an Emerging Treatment Modality in Immune-Mediated Inflammatory Diseases: A Narrative Review.https://www.psoriasis-news.de/articles.html/1_articles/oral-peptide-therapeutics-as-an-emerging-treatment-modality-in-immune-mediated-inflammatory-diseases-a-narrative-review-r57/Weiterlesen

]]>57Sat, 31 May 2025 17:47:51 +0000Early Peripheral Psoriatic Arthritis: Baseline Features of the First 186 Patients in the French Nationwide APACHE Cohort.https://www.psoriasis-news.de/articles.html/1_articles/early-peripheral-psoriatic-arthritis-baseline-features-of-the-first-186-patients-in-the-french-nationwide-apache-cohort-r56/Weiterlesen

]]>56Sat, 31 May 2025 17:47:51 +0000