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<rss version="2.0"><channel><title>Neue Studien: Europe PMC</title><link>https://www.psoriasis-news.de/articles.html/1_articles/page/3/?d=1</link><description>Neue Studien: Europe PMC</description><language>de</language><item><title>Lower CALLY index values are associated with higher disease activity in psoriatic arthritis: a retrospective cohort study.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/lower-cally-index-values-are-associated-with-higher-disease-activity-in-psoriatic-arthritis-a-retrospective-cohort-study-r653/</link><description><![CDATA[Assessing disease activity in psoriatic arthritis (PsA) remains challenging, and additional biomarkers that can complement conventional inflammatory markers are still needed. The CRP-albumin-lymphocyte (CALLY) index integrates inflammatory, immune, and nutritional components into a single measure. This study examined the relationship between the CALLY index and disease activity in patients with PsA. This retrospective longitudinal cohort study included 150 patients with PsA and 50 age- and sex-matched healthy controls. Blood-derived inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), pan-immune inflammation value (PIV), and the CALLY index, were calculated using routine laboratory data. Disease activity was evaluated with the clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA). Correlation analyses, receiver operating characteristic (ROC) analyses, subgroup analyses, and multivariable logistic regression models were performed. Patients with moderate-to-high disease activity had markedly lower CALLY index values than those with remission or low disease activity. The CALLY index showed a moderate inverse correlation with cDAPSA scores (r = - 0.529, p &lt; 0.001). During follow-up, CALLY values increased significantly in both csDMARD-treated and biologic-treated patients (both p &lt; 0.001), whereas no significant differences were observed between treatment groups. In multivariable analysis, lower log-transformed CALLY index values remained independently associated with moderate-to-high disease activity (OR 0.39, 95% CI 0.23-0.66). The discriminative performance of the CALLY index was similar to that of CRP (AUC 0.724 vs. 0.738; p = 0.42). Lower CALLY index values were linked to greater disease activity in PsA and improved alongside reductions in inflammatory burden during follow-up. Although its performance was comparable to CRP rather than superior, the CALLY index may represent a useful complementary biomarker for disease activity assessment in PsA. Prospective studies are needed to further clarify its clinical utility.<p><a href="http://europepmc.org/article/MED/42377589?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">653</guid><pubDate>Fri, 03 Jul 2026 07:03:51 +0000</pubDate></item><item><title>Molecular dissection of CD28-associated cytokine signaling in early psoriasis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/molecular-dissection-of-cd28-associated-cytokine-signaling-in-early-psoriasis-r652/</link><description><![CDATA[<h4>Background</h4>Psoriasis is a chronic immune-mediated skin disorder characterized by excessive keratinocyte proliferation and abnormal T-cell activation. Cluster of Differentiation 28 (CD28), a costimulatory protein, plays a crucial role in psoriasis pathophysiology by enhancing T-cell activation and promoting cytokine release.<h4>Methods</h4>A case-control study was involving 168 newly diagnosed psoriasis patients and 159 healthy control individuals (HC), Genotyping of rs1879877 in promoter of CD28 gene was performed using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR), and serum levels of soluble CD28 (sCD28) and selected cytokines (Interleukin (IL), IL-38, IL-39 and Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)) were measured using sandwich enzyme-linked immunosorbent assay (ELISA).<h4>Results</h4>The heterozygous GT genotype was predominant among psoriasis patients and was significantly associated with elevated serum sCD28 levels compared to controls, who predominantly carried the wild type GG genotype. Elevated sCD28 levels were linked to increased T-cell activation, contributing to immune dysregulation and disease severity. This was evidenced by increased production of pro-inflammatory cytokines, including IL-39 and GM-CSF, with a concurrent decrease in the anti-inflammatory cytokine IL-38.<h4>Conclusion</h4>Serum sCD28 levels were significantly elevated in psoriasis patients. The CD28 gene variant rs1879877 (-1198 G/T) appears to be associated with psoriasis pathogenesis, potentially due to increased transcriptional activity that elevates sCD28 expression, thereby influencing T-cell activation and immune modulation.<p><a href="http://europepmc.org/article/MED/42363986?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">652</guid><pubDate>Fri, 03 Jul 2026 07:03:51 +0000</pubDate></item><item><title>Biologic therapies in pediatric psoriasis: A single-center experience.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/biologic-therapies-in-pediatric-psoriasis-a-single-center-experience-r651/</link><description><![CDATA[Pediatric psoriasis accounts for approximately 2% of dermatological conditions in children under 16 years of age. The objective of this study is to describe the clinical characteristics, treatment regimens, and observed efficacy and safety profiles in a real-world cohort. This retrospective study analyzed 15 pediatric patients treated with biologics in Argentina between 2010 and 2024. The median age at treatment initiation was 8 years, with a predominance of female patients. The biologics used were primarily adalimumab, followed by secukinumab, etanercept, and ixekizumab. Five patients experienced treatment failure secondary to adalimumab. The therapy was well tolerated, with no adverse events reported.The data suggest that early intervention can alter the course of the disease and prevent long-term complications.<p><a href="http://europepmc.org/article/MED/42377011?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">651</guid><pubDate>Fri, 03 Jul 2026 07:03:51 +0000</pubDate></item><item><title>Clinical Characteristics, Healthcare Resource Utilization, and Costs of Patients with Generalized Pustular Psoriasis in Taiwan: A National Claims Database Study.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/clinical-characteristics-healthcare-resource-utilization-and-costs-of-patients-with-generalized-pustular-psoriasis-in-taiwan-a-national-claims-database-study-r650/</link><description><![CDATA[<h4>Background</h4>Generalized pustular psoriasis (GPP) is a rare and severe inflammatory disease characterized by widespread pustular eruptions and systemic inflammation.<h4>Objective</h4>To evaluate the clinical characteristics and disease burden of patients with GPP in Taiwan using a national claims database.<h4>Methods</h4>Patients with GPP and no prior diagnosis of psoriasis vulgaris (PV) who experienced an incident flare between January 1, 2017, and September 30, 2020, were identified from Taiwan's National Health Insurance Database. Clinical characteristics, comorbidities, and treatment patterns were described. Recurrent flare frequency, healthcare resource utilization (HCRU) and costs were compared with those of a propensity score-matched PV cohort at a ratio of up to 1:4. Outpatient-managed flares were classified as moderate, whereas hospitalized flares were classified as severe.<h4>Results</h4>A total of 245 patients with GPP were included (mean age 51.3 years; 49.8% male). During follow-up, 1,156 moderate-to-severe flares were identified. Compared with matched patients with PV, patients with GPP had a higher recurrent flare rate (rate ratio 1.14; 95% CI 1.06-1.23). Patients with GPP also had greater HCRU, including more outpatient visits (incidence rate ratio [IRR] 1.03 [95% CI 1.01-1.05]), emergency room visits (IRR 1.33, 95% CI 1.19-1.49), and hospital admissions (IRR 1.69 [1.50-1.91]). Median monthly healthcare costs were approximately twice as high among patients with GPP as among matched patients with PV.<h4>Conclusion</h4>Patients with GPP experienced recurrent flares, greater healthcare utilization, and higher healthcare costs than matched patients with PV, underscoring the substantial real-world clinical and economic burden of GPP.<p><a href="http://europepmc.org/article/MED/42389669?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">650</guid><pubDate>Fri, 03 Jul 2026 07:03:51 +0000</pubDate></item><item><title>Real-World Effectiveness of Tildrakizumab in Japanese Patients With Psoriasis: Analyses Stratified by Prior Systemic Therapy, Maintenance of Early Responses, and Achievement of Delayed Responses.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/real-world-effectiveness-of-tildrakizumab-in-japanese-patients-with-psoriasis-analyses-stratified-by-prior-systemic-therapy-maintenance-of-early-responses-and-achievement-of-delayed-responses-r649/</link><description><![CDATA[There are no real-world studies on the long-term effectiveness of anti-interleukin-23 antibody tildrakizumab in Japanese patients with psoriasis stratified by pretreatment status. To evaluate the 52-week real-world effectiveness of tildrakizumab for psoriasis patients, stratified by prior systemic therapy, prior biologic therapy, or prior deucravacitinib treatment, and to assess the maintenance of week 16 responses and achievement of delayed responses in patients without week 16 responses. This study included 57 patients with psoriasis treated with tildrakizumab. Psoriasis area and severity index (PASI) and static physician's global assessment (sPGA) were analyzed through week 52 in subgroups stratified by the presence or absence of prior systemic therapy, prior biologic therapy, or prior deucravacitinib treatment. Patients who achieved PASI 75, PASI 90, PASI 100, absolute PASI ≤ 3, absolute PASI ≤ 2, or sPGA 0/1 at week 16 were assessed for the maintenance of respective responses, and patients without week 16 responses were assessed for the achievement of delayed responses through week 52. Analyses were descriptive and used an as-observed approach. Tildrakizumab reduced PASI throughout 52 weeks regardless of the presence or absence of prior systemic therapy, prior biologic therapy, or prior deucravacitinib treatment. Responses achieved at week 16 were mostly maintained through week 52. Some patients without week 16 responses achieved delayed responses by week 52. Tildrakizumab reduced PASI throughout 52 weeks in patients with psoriasis regardless of prior systemic therapy, prior biologic therapy, or prior deucravacitinib treatment. Responses achieved at week 16 were mostly sustained through week 52. Some patients without week 16 responses could achieve delayed responses by week 52.<p><a href="http://europepmc.org/article/MED/42385169?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">649</guid><pubDate>Fri, 03 Jul 2026 07:03:51 +0000</pubDate></item><item><title>Two-dimensional GeTe nanosheets for psoriasis through modulation of macrophage activation and psoriatic inflammation.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/two-dimensional-gete-nanosheets-for-psoriasis-through-modulation-of-macrophage-activation-and-psoriatic-inflammation-r648/</link><description><![CDATA[Psoriasis is a chronic inflammatory disease characterized by thickened erythematous skin lesions covered with white and silvery scales and accompanied by macrophage infiltration into the dermis. Although 2-3% of the world's population suffers from psoriasis, there is still a requirement for novel, safe, and effective treatment options. Previously, our group demonstrated the theranostic effects of two-dimensional germanium telluride nanosheets (GeTe-NSs) in the treatment of inflammatory bowel disease. However, the precise mechanisms underlying their therapeutic action remained unclear. In this study, the specific anti-inflammatory mechanisms of GeTe-NSs in lipopolysaccharide-stimulated RAW 264.7 macrophages were evaluated, along with their therapeutic potential for psoriasis treatment in an imiquimod (IMQ)-induced murine model. GeTe-NS treatment significantly decreased cell proliferation and reduced the production of reactive nitrogen and oxygen species in activated RAW 264.7 macrophages. The GeTe-NSs lowered the mRNA levels of key pro-inflammatory mediators (Nos2, Tnf, Ccl2, and Cxcl15), while enhancing the mRNA levels of an anti-inflammatory factor (Arg1) and an antioxidant enzyme (Nqo1). Flow cytometric analysis revealed that the GeTe-NSs promoted a shift from the M1 (pro-inflammatory) macrophage phenotype toward the M2 (anti-inflammatory) phenotype. Western blot analysis demonstrated that anti-inflammatory effects were achieved by inhibiting the activation of the TLR4/CD14 and ERK/NF-kB/STAT1/STAT3 pathways. <i>In vivo</i>, the oral administration of GeTe-NSs in an IMQ-induced psoriasis mouse model resulted in significant improvements in clinical scores, epidermal thickening, and the proportions of M1/M2 macrophages in spleen and skin lesions. Taken together, these findings suggest that GeTe-NSs could be a promising nanomaterial for treating inflammatory diseases, including psoriasis.<p><a href="http://europepmc.org/article/MED/42188281?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">648</guid><pubDate>Fri, 03 Jul 2026 07:03:51 +0000</pubDate></item><item><title><![CDATA[Extracellular vesicles as biomarkers for psoriatic arthritis: a systematic review & meta-analysis]]></title><link>https://www.psoriasis-news.de/articles.html/1_articles/extracellular-vesicles-as-biomarkers-for-psoriatic-arthritis-a-systematic-review-meta-analysis-r647/</link><description><![CDATA[<h4>Background</h4>  Psoriatic arthritis (PsA) is an inflammatory condition involving joints, tendon-bone entheses and synovium that can develop in individuals with psoriasis. Early, accurate clinical diagnosis remains difficult. Extracellular vesicles (EVs) carry proteins and miRNAs that <h4>Methods</h4>  PubMed and Embase were searched from inception through May 21st, 2026, and human studies examining EV-associated protein or miRNA biomarkers in PsA and related psoriatic or inflammatory diseases were included, with risk of bias assessed using a modified Newcastle-Ottawa Scale and diagnostic accuracy summarized using HSROC/BRMA models when data were sufficient. <h4>Results</h4>  Seven studies met the inclusion criteria, including 119 individuals with PsA (weighted mean age: 49.8 years; 43.7% female), 205 individuals with non-PsA psoriasis (weighted mean age: 46.4 years; female %: NA), 55 controls (weighted mean age: 44.5 years; 38.2% female), and 50 individuals with other inflammatory joint disorders (weighted mean age: 58.0 years; 58.0% female). EV-associated protein markers demonstrated heterogeneous findings related to immune, vascular, inflammatory, and osteoimmunological signaling. Only 4.2% (4/95) of miRNAs were consistently identified across studies comparing PsA with non-PsA psoriasis, with lower overlap (1.5%, 1/67) in studies comparing PsA with controls. ROC meta-analysis suggested preliminary diagnostic potential, particularly for distinguishing PsA from non-PsA psoriasis, although evidence was constrained by small study numbers. <h4>Conclusions</h4>  EV-associated proteins and miRNAs are potential biomarker candidates for PsA, reflecting inflammatory, vascular, and osteoimmunological processes underlying disease pathophysiology. However, current evidence remains preliminary and limited by small cohorts, methodological heterogeneity, and inconsistent reporting across studies.<p><a href="http://europepmc.org/article/PPR/PPR1259760?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">647</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>A Serum N-Glycan Ratio Associated With Disease Severity and Treatment Response in Psoriasis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/a-serum-n-glycan-ratio-associated-with-disease-severity-and-treatment-response-in-psoriasis-r646/</link><description><![CDATA[Psoriasis is a chronic, immune-mediated inflammatory disease with heterogeneous manifestations. Reliable biomarkers reflecting disease severity and treatment response remain limited. Glycans-carbohydrate structures attached to proteins and lipids-play key roles in biological processes, contributing to functional specificity. Abnormal glycosylation has been implicated in the pathogenesis of inflammatory and neoplastic diseases, highlighting their potential as therapeutic targets and biomarkers. This study aimed to evaluate serum N-glycan profiles as potential biomarkers for psoriasis, focusing on the ratio of sialylated biantennary N-glycan (S) to fucosylated asialo-biantennary N-glycan (FA), termed the S/FA ratio. Serum samples from 45 patients with psoriasis, 12 with atopic dermatitis (AD), and 19 healthy controls were analyzed using high-performance liquid chromatography. The performance of the S/FA ratio was compared with reported biomarkers (CRP and CCL20), and its associations with Psoriasis Area and Severity Index (PASI) and treatment response were examined. The S/FA ratio was significantly higher in psoriasis than in healthy controls (p &lt; 0.001) and correlated with PASI (r = 0.485, p &lt; 0.001) and its components. Receiver operating characteristic analysis showed comparable diagnostic accuracy among the S/FA ratio (AUC = 0.788, sensitivity: 73.7%, specificity: 73.3%), CRP (AUC = 0.780), and CCL20 (AUC = 0.741). Changes in the S/FA ratio were correlated with improvements in PASI after systemic treatment (r = 0.467, p = 0.002), including a patients subgroup receiving IL-23 inhibitors. The S/FA ratio was not significantly influenced by demographics, comorbidities, or arthralgia. No significant difference was observed between psoriasis and AD, and the S/FA ratio was not significantly elevated in AD compared with healthy controls. The serum S/FA ratio may serve as a glycan-based biomarker associated with disease severity and treatment response in psoriasis, although its ability to distinguish psoriasis from other inflammatory diseases requires further validation in larger and treatment-naïve cohorts.<p><a href="http://europepmc.org/article/MED/42338141?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">646</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>Exploring the Gut Microbiome's Association in Psoriasis and Psoriatic Arthritis: A Scoping Review.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/exploring-the-gut-microbiomes-association-in-psoriasis-and-psoriatic-arthritis-a-scoping-review-r645/</link><description><![CDATA[<h4>Introduction</h4>Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic inflammatory conditions treated with primarily immune-modulating medication. However, interest is growing in gut microbiome therapies. Studies have reported altered gut microbiota in PsO/PsA and explored probiotics and fecal microbiota transplantation (FMT) as potential therapies. This review synthesizes global studies on the microbiome's associations in PsO/PsA.<h4>Methods</h4>We conducted a scoping literature review to understand the association between gut microbiota in PsO and PsA patients. Pubmed was used to identify 4,126 published manuscripts between 2015-2025. Thirty studies were included, encompassing 749,275 participants, with balanced gender representation and ages ranging from 18 to 76 years. These studies included 21 case-control studies, 1 case-series, 2 genome-wide analyses, 5 clinical trials, and 1 retrospective review.<h4>Results</h4>Eighteen studies reported significant gut microbiome differences in PsO/PsA vs healthy controls. Variation in the Firmicutes/Bacteroides (F/B) ratio was of interest, with one study suggesting a low F/B ratio and five studies suggesting an elevated F/B ratio in PsO. A higher F/B ratio was linked to increased acetate production. Acetate and propionate, key short-chain fatty acids (SCFAs), were associated with modulation of the IL-23/Th17 axis in psoriasis and activation of keratinocytes. The role of therapeutics targeting the gut microbiome was explored. Ustekinumab and tofacitinib altered gut microbiome composition. Probiotic and FMT interventions showed mixed outcomes. Six of eight probiotic studies reported increased SCFA producing species and/or reduced inflammatory markers. FMT improved immune markers in mice but had no significant benefit in human trials.<h4>Conclusion</h4>Alterations in the microbiome linked to inflammation and immune response, suggest the microbiome as a potential therapeutic target for PsO/PsA.<p><a href="http://europepmc.org/article/MED/42358596?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">645</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>A cohort study of obese patients with moderate-to-severe psoriasis using biological medicines in Catalonia, Spain.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/a-cohort-study-of-obese-patients-with-moderate-to-severe-psoriasis-using-biological-medicines-in-catalonia-spain-r644/</link><description><![CDATA[Obesity impacts both the clinical management and therapeutic strategies for psoriasis. This study aims to describe the use of biological medicines in treating obese patients with moderate-to-severe psoriasis. We conducted a retrospective cohort study (2007-2022) of obese patients who initiated biological treatments for moderate-severe psoriasis. The primary outcome was the number of biological treatment lines required to achieve an optimal or adequate Psoriasis Area and Severity Index (PASI) score reduction. Secondary outcomes included the duration of biological use and reasons for discontinuation. We included 58 patients (mean age 50 years, body mass index [BMI] 35.9 kg/m2, psoriasis duration 16.5 years). Biological treatments enabled 77.6% (45) of patients to achieve an optimal response, and 87.9% (51) achieved an adequate response. The median time-to-response was 2-7 months, with the greatest improvements seen with adalimumab, etanercept, and ustekinumab. The primary reason for discontinuation was lack of effectiveness (50% of first-line treatments). This study suggests that systemic biologics are effective for obese psoriasis patients and emphasizes the need for close monitoring of reasons that lead to discontinuation. As biologics evolve, refining guidelines will be essential for optimizing psoriasis management in obese patients.<p><a href="http://europepmc.org/article/MED/42334449?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">644</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title><![CDATA[Efficacy of vunakizumab in patients with moderate-to-severe plaque psoriasis across diverse disease features: a &lt;i&gt;post hoc&lt;/i&gt; analysis of a phase-III trial.]]></title><link>https://www.psoriasis-news.de/articles.html/1_articles/efficacy-of-vunakizumab-in-patients-with-moderate-to-severe-plaque-psoriasis-across-diverse-disease-features-a-ltigtpost-hocltigt-analysis-of-a-phase-iii-trial-r643/</link><description><![CDATA[<h4>Background</h4>The efficacy of interleukin-17 inhibitors may be impacted by baseline psoriasis features.<h4>Objective</h4>This <i>post hoc</i> analysis aimed to explore the efficacy of vunakizumab in patients with moderate-to-severe plaque psoriasis stratified by diverse disease features.<h4>Methods</h4>This post hoc analysis used data from a phase III trial (NCT04839016); 690 patients with moderate-to-severe plaque psoriasis receiving vunakizumab (<i>n</i> = 461) or placebo (<i>n</i> = 229) were included.<h4>Results</h4>The proportions of patients achieving Psoriasis Area and Severity Index (PASI) 75, PASI 90, PASI 100, and static physician's global assessment (sPGA) 0/1 responses at week (W)12 were significantly higher in the vunakizumab group than in the placebo group, regardless of the duration of psoriasis, PASI score, body surface area (BSA) involvement, and sPGA score. Similarly, at W4 and W8, treatment response rates were higher in the vunakizumab group than in the placebo group, regardless of the above-mentioned features. The same trend was also found at W24. However, treatment responses at W52 were almost not different between patients continuously receiving vunakizumab and those switching from placebo to vunakizumab, regardless of disease duration and disease severity.<h4>Conclusion</h4>Vunakizumab shows satisfactory efficacy in patients with moderate-to-severe plaque psoriasis, regardless of psoriasis duration and severity.<p><a href="http://europepmc.org/article/MED/42333837?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">643</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>Psoriasis, Atopic Dermatitis, Acne, Inverse Psoriasis and Hidradenitis: A Case Report of Multiple Disease in a Same Young Patient.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/psoriasis-atopic-dermatitis-acne-inverse-psoriasis-and-hidradenitis-a-case-report-of-multiple-disease-in-a-same-young-patient-r642/</link><description><![CDATA[We report a case of a 17-year-old girl diagnosed with several severe dermatological conditions: atopic dermatitis (AD), inverse and scalp psoriasis, pustular acne, and hidradenitis suppurativa (HS). We consider this case of particular interest because it is therapeutically challenging and because of its psychological impact on the patient's quality of life. We believe that this case may be useful in understanding the management of complex dermatoses as inescapable from the overall assessment of the inflammatory process, which impacts at different levels (skin, cardiovascular, central nervous system, and psyche).<p><a href="http://europepmc.org/article/MED/42343938?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">642</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>Frequency of complex-to-manage, difficult-to-manage and treatment-refractory psoriatic arthritis: applying the 2025 GRAPPA and EULAR definitions in a real-world longitudinal PsA cohort.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/frequency-of-complex-to-manage-difficult-to-manage-and-treatment-refractory-psoriatic-arthritis-applying-the-2025-grappa-and-eular-definitions-in-a-real-world-longitudinal-psa-cohort-r641/</link><description><![CDATA[<h4>Objectives</h4>To determine the frequency and baseline characteristic differences of complex-to-manage (C2M), difficult-to-manage (D2M) and treatment-refractory (TR) psoriatic arthritis (PsA) in a real-world longitudinal cohort, using the recently proposed 2025 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the European Alliance of Associations for Rheumatology (EULAR) definitions.<h4>Methods</h4>We analysed data from newly diagnosed, disease-modifying antirheumatic drug-naïve patients with PsA enrolled in the Dutch Southwest Early Psoriatic Arthritis cohort between 2013 and 2023. Patients were classified using the 2025 GRAPPA (C2M, TR) and EULAR (D2M, TR) PsA definitions. Frequencies were calculated for each definition. Time-to-event analyses using Kaplan-Meier methods assessed the timing of definition fulfilment and individual components. Longitudinal differences in patient-reported outcomes (PROs) were assessed using linear mixed-effects models.<h4>Results</h4>Among 885 newly diagnosed patients with PsA, 20% (179/885) fulfilled the GRAPPA-C2M definition, 4.2% (37/885) fulfilled the EULAR-D2M definition, 3.8% (34/885) met the EULAR-TR and 1.2% (11/885) fulfilled the GRAPPA-TR criteria definition during follow-up. Female sex, higher body mass index (BMI), longer symptom duration, presence of enthesitis and greater skin involvement differed with meeting definitions at baseline. Patients classified as GRAPPA-C2M, GRAPPA-TR, EULAR-D2M and EULAR-TR consistently reported worse long-term PROs (Health Assessment Questionnaire-Disability Index scores in C2M (β=0.17, 95% CI 0.10 to 0.24), GRAPPA-TR (β=0.37, 95% CI 0.22 to 0.51), EULAR-D2M (β=0.36, 95% CI 0.20 to 0.48) and EULAR-TR (β=0.40, 95% CI 0.25 to 0.55)).<h4>Conclusions</h4>Approximately 20% of patients with early PsA fulfilled the GRAPPA-C2M criteria, representing the earliest and broadest subgroup, while 4% met EULAR-D2M/EULAR-TR and 1.2% GRAPPA-TR definitions. These latter subgroups were more likely to be female, had higher BMI, greater skin involvement and enthesitis and experienced persistently worse PROs, underscoring the need for tailored management strategies.<p><a href="http://europepmc.org/article/MED/42336609?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">641</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>A Review of Male Genital Psoriasis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/a-review-of-male-genital-psoriasis-r640/</link><description><![CDATA[Male genital psoriasis (mGP) is an inflammatory dermatosis affecting the penis and scrotum, a common but significantly under-reported manifestation of psoriasis. Owing to the unique anatomical and microenvironmental characteristics of the male genital region, mGP differs from chronic plaque psoriasis in its clinical presentation, exacerbating factors and therapeutic considerations. Similar to other forms of psoriasis, mGP carries a substantial psychosocial burden. This is amplified by the intimate nature of mGP and its detrimental effects on sexual and interpersonal functioning, which is often overlooked in routine consultations. This narrative review aims to summarise the presentation, consequences and management options of mGP. Assessment of disease severity is further challenged by limited body surface area involvement, leading to underestimation by conventional psoriasis severity measurement tools. Moreover, certain established treatments for psoriasis are unsuitable in mGP due to differing microanatomy and increased susceptibility to adverse effects. Despite its significant physical and psychosocial impact, mGP remains an under-recognised and under-studied subtype of psoriasis with no therapies specifically approved. Existing studies seldomly distinguish genital from inverse psoriasis, and even fewer distinguish male from female GP. The nuances of mGP merit dedicated clinical trials using validated and specific measurement tools to accurately characterise mGP and evaluate treatment efficacy.<p><a href="http://europepmc.org/article/MED/42339528?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">640</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>Lymphocyte-Platelet and Neutrophil-Platelet Aggregates are Associated with Dysregulated Platelet Inflammatory Pathways in Psoriasis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/lymphocyte-platelet-and-neutrophil-platelet-aggregates-are-associated-with-dysregulated-platelet-inflammatory-pathways-in-psoriasis-r639/</link><description><![CDATA[<h4>Background</h4>Psoriasis is a chronic immune-mediated inflammatory disease associated with heightened cardiovascular risk. Platelets are increasingly implicated in this link through their capacity to amplify vascular inflammation and interact with leukocytes. Circulating leukocyte-platelet aggregates are elevated in psoriasis, although the biological significance of these aggregates remains incompletely understood. We investigated whether increased leukocyte-platelet aggregates is associated with alterations in the platelet transcriptomic profile in psoriasis.<h4>Methods</h4>Leukocyte-platelet aggregate levels were compared between psoriasis patients (n = 42) and healthy controls (n = 29). Psoriasis patients were stratified by the cohort median lymphocyte-platelet aggregate (LyPA) or neutrophil-platelet aggregate (NPA) levels into high vs low aggregate groups. Platelet RNA sequencing was then performed to define transcriptomic differences in high-vs low-aggregate psoriasis.<h4>Results</h4>Psoriasis patients (mean age 46; 60% male; 81% Caucasian) had higher LyPA (<i>P</i> = 0.001) and NPA (<i>P</i> = 0.04) compared with healthy controls (mean age 42; 55% male; 69% Caucasian). Platelet RNA sequencing revealed that psoriasis patients with high LyPA or high NPA had downregulation of platelet inflammatory pathways, including interferon, tumor necrosis factor (TNF), IL-8, and IL-6 signaling.<h4>Conclusion</h4>These findings identify inflammatory platelet transcriptomic alterations associated with elevated lymphocyte-platelet and neutrophil-platelet aggregates in psoriasis and motivate further work to define the functional consequences of leukocyte-platelet aggregates in psoriasis.<p><a href="http://europepmc.org/article/MED/42358595?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">639</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>Dual targeting of cutaneous inflammation and vasculopathy via STING-NF-&#x3BA;B blockade underlies the anti-psoriatic efficacy of Yinxie Granules.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/dual-targeting-of-cutaneous-inflammation-and-vasculopathy-via-sting-nf-%CE%BAb-blockade-underlies-the-anti-psoriatic-efficacy-of-yinxie-granules-r638/</link><description><![CDATA[Psoriasis is a chronic skin disease driven by skin inflammation and abnormal subcutaneous blood vessels. Yinxie Granules (YXKL) is a clinically effective traditional Chinese medicine (TCM) formula that has shown promise in psoriasis treatment, but its pharmacological mechanisms and material basis remain unclear, limiting its clinical application and co-administration with other drugs. In this study, we explored the mechanism and active components of YXKL in the treatment of psoriasis using patient samples, IMQ-induced psoriatic mice, zebrafish, and in vitro assays. We discovered that YXKL alleviated skin inflammation and restored the skin barrier by reducing M1 macrophage/Th17 infiltration, lowering pro-inflammatory cytokines (IL-6, IFN-β, IL-23, IL-17), and increasing loricrin expression. Mechanistically, we identified a dynamic transition in STING signaling during psoriasis progression. Both the STING/IRF3 and STING/NF-κB pathways were activated in moderate psoriasis, while only the STING/NF-κB pathway was hyperactivated in severe disease. YXKL specifically targeted the STING/NF-κB pathway to mitigate inflammation and vasculopathy but had no significant impact on the upstream regulators, including TRAF6, LKB1, AMPK, and ULK1. Quercetin and kaempferol were identified as the primary STING-modulating components in YXKL, binding to STING proteins and inhibiting downstream pathway activation. These flavonoid components mediate the anti-psoriatic effects of YXKL by simultaneously suppressing skin inflammation and angiogenesis while enhancing vascular integrity through STING inhibition in both keratinocytes and endothelial cells. Our results elucidated the molecular basis of YXKL for psoriasis treatment, highlighting STING/NF-κB as a pivotal therapeutic target in mitigating psoriasis development and providing natural candidate compounds as potential STING inhibitors.<p><a href="http://europepmc.org/article/MED/42285688?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">638</guid><pubDate>Mon, 29 Jun 2026 08:21:12 +0000</pubDate></item><item><title>Musculoskeletal and nail ultrasound findings in children with psoriasis: a case-control study.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/musculoskeletal-and-nail-ultrasound-findings-in-children-with-psoriasis-a-case-control-study-r632/</link><description><![CDATA[<h4>Background</h4>Children with psoriasis can develop juvenile psoriatic arthritis. Musculoskeletal ultrasound is a helpful imaging modality in the early recognition of joint inflammation. This pilot study aims to describe clinical and subclinical joint and nail abnormalities in children with psoriasis.<h4>Methods</h4>Children with psoriasis and healthy controls underwent ultrasound examination of various joints, entheses, and nails. Using a standard acquisition protocol, images were obtained in both B-mode and PD-mode. Differences between psoriasis and control groups were examined.<h4>Results</h4>Fifteen psoriasis patients who were not on systemic therapy and did not have clinical signs of arthritis and thirteen age- and sex-matched healthy controls were enrolled. While patients with psoriasis demonstrated subclinical synovitis in the finger, knee, and ankle joints more frequently than the control group (p = 0.047), no statistically significant difference was observed in the comparison of each specific joint. PD positivity was detected at the entheses in two patients with psoriasis and at three entheseal sites of two healthy children. Nail ultrasound examination demonstrated significantly thicker nail beds (1.6 vs. 1.4 mm, p &lt; 0.001) and more frequent abnormal nail structure (70% vs. 21.2%, p &lt; 0.001) in the psoriasis group compared to control group while the thickness of the nail plate and nail matrix were similar. Type II nail morphology changes were the most frequently detected type according to the Wortsman classification. Positive PD-mode findings in the nail bed and nail matrix were more common in the control group (both p &lt; 0.001). Among the psoriasis cohort, nails with abnormal exam findings had significantly thicker nail plate (0.4 vs. 0.35 mm, p = 0.003) and nail bed (1.8 vs. 1.6 mm, p = 0.006) measurements compared to nails with normal examination.<h4>Conclusions</h4>Ultrasound is a useful tool for evaluating inflammatory joint and nail findings that may help delineate subclinical joint inflammation in children with psoriasis.<p><a href="http://europepmc.org/article/MED/42143389?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">632</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Alkannin ameliorates imiquimod-induced murine psoriasis by targeting MrgprX2-mediated mast cell activation.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/alkannin-ameliorates-imiquimod-induced-murine-psoriasis-by-targeting-mrgprx2-mediated-mast-cell-activation-r631/</link><description><![CDATA[Activated mast cells (MCs) are crucial effectors in the initiation and progression of psoriasis by secreting inflammatory mediators. The MC activation mediated by Mas-related G-protein-coupled receptor X2 (MrgprX2) has been implicated in psoriasis progression. However, the therapeutic strategies targeting MrgprX2 for psoriasis treatment remain less explored. Alkannin (Alk) is the main active component of the plant Arnebia euchroma and exhibits significant anti-inflammatory activities. However, in psoriasis, the effect of Alk on MCs and MrgprX2 remains elusive. In psoriatic mouse models, Alk alleviated epidermal hyperplasia, vascular dilation, and splenomegaly, regulated the Th17 to Treg cells ratio, and reduced the proinflammatory cytokine levels. In vitro analyses indicated that Alk inhibited β-hexosaminidase release, downregulated the expression of inflammation-related cytokines, and reduced intracellular Ca2+ levels in a MrgprX2-dependent manner. Moreover, SPR, CETSA, DARTS, and molecular docking assays revealed a direct interaction between Alk and MrgprX2, suggesting that Alk targets MrgprX2 to inhibit MC activation. Furthermore, Alk inhibited the downstream PLCγ-IP3R-PKC-ERK signaling pathways via targeting MrgprX2. Consistently, in vivo functional assays confirmed that Alk inhibits MrgprB2-related MC activation, a critical process driving psoriatic symptom progression. Collectively, these results demonstrate that Alk directly binds to MrgprX2 and modulates MC activation by inhibiting downstream PLCγ-IP3R-PKC-ERK signaling pathways, thus mitigating psoriasis symptoms. These findings provide a novel target and theoretical basis for the treatment of psoriasis.<p><a href="http://europepmc.org/article/MED/42176861?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">631</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Feasibility of Ultrashort Echo Time MR Imaging for the Detection of Subclinical Achilles Enthesitis in Psoriasis and Psoriatic Arthritis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/feasibility-of-ultrashort-echo-time-mr-imaging-for-the-detection-of-subclinical-achilles-enthesitis-in-psoriasis-and-psoriatic-arthritis-r630/</link><description><![CDATA[Subclinical inflammation (SI) is clinically relevant in psoriasis (PsO) and psoriatic arthritis (PsA), but quantitative imaging biomarkers are lacking. We evaluated the feasibility of ultrashort echo time (UTE) bicomponent MRI for quantifying Achilles enthesis SI. Conventional MRI showed no group differences, whereas short T2* (T2*<sub>s</sub>) values were significantly elevated in PsO/PsA compared with healthy volunteers. These findings support the feasibility of UTE bicomponent analysis, as a promising tool for evaluating SI and warrant further investigation.<p><a href="http://europepmc.org/article/MED/42161535?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">630</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Durability of response to icotrokinra for high-impact site psoriasis: 1-year ICONIC-TOTAL findings.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/durability-of-response-to-icotrokinra-for-high-impact-site-psoriasis-1-year-iconic-total-findings-r629/</link><description><![CDATA[High-impact site plaque psoriasis is difficult to treat. Icotrokinra, an oral peptide with high specificity for the interleukin (IL)-23 receptor, demonstrated significantly higher rates of high-impact site psoriasis clearance, versus placebo, with no safety signals, through Week (W)16. Report clinical response rates and safety through 1 year of icotrokinra treatment in participants with high-impact site plaque psoriasis. Participants (≥12 years of age; psoriasis body surface area ≥1%; Investigator's Global Assessment [IGA] ≥2) with at least moderate scalp, genital or hand/foot psoriasis were randomized (2:1) to once-daily icotrokinra 200 mg (N = 208) or placebo (N = 103), with placebo-to-icotrokinra transition at W16 (N = 92). Rates (using nonresponder imputation) of achieving clear/almost clear (0/1) or clear (0) overall skin (IGA), genital (static Physician's Global Assessment of genitalia [sPGA-G]), hand/foot (hf-PGA) psoriasis and absent/very mild (0/1) or absent (0) scalp psoriasis (scalp-specific-IGA [ss-IGA]), modified Nail Psoriasis Severity Index (mNAPSI) percent improvement and safety were assessed through W52. Eighty-eight per cent (275/311) of participants completed treatment through W52. In icotrokinra-randomized participants, response rates increased through W24 and were durable through W52 for overall psoriasis clearance (IGA 0/1 range: 67%-70%) and across high-impact sites (ss-IGA 0/1: 72%-78%; sPGA-G 0/1: 85%-90%; hf-PGA 0/1: 54%-62%); responses were consistent among placebo-randomized participants after transitioning to icotrokinra. High proportions of icotrokinra-randomized participants achieved complete clearance during W24-52 (IGA 0: 44%-51%; ss-IGA 0: 57%-66%; sPGA-G 0: 73%-84%; hf-PGA 0: 44%-58%). Mean mNAPSI improvement increased from W16 (33%) to W52 (62%). Exposure-adjusted rates of participants with ≥1 adverse event (AE) or serious AE through W16 were similar between icotrokinra and placebo, with no increase in AE rates or occurrence of a safety signal through W52. Icotrokinra demonstrated high and durable rates of psoriasis clearance across high-impact sites, with a favourable safety profile, through 1 year.<p><a href="http://europepmc.org/article/MED/42175814?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">629</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Drug-induced psoriasis following sacubitril/valsartan: a case report and literature review.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/drug-induced-psoriasis-following-sacubitrilvalsartan-a-case-report-and-literature-review-r628/</link><description><![CDATA[Drug exposure is one of the potential mechanisms implicated in the onset or exacerbation of psoriasis. To date, several cardiovascular agents have been implicated. Sacubitril/valsartan (SV) has been widely used in the treatment of hypertension and heart failure (HF). Its common adverse reactions include angioedema, hypotension, renal impairment, and hyperkalemia. However, SV may cause psoriasis, which needs clinical attention. This report describes a case of a middle-aged male patient who developed psoriasis following SV therapy. The rashes presented as well-demarcated red or violaceous plaques with noticeable scaling. After being diagnosed with psoriasis, he was started on topical clobetasol propionate ointment, and SV was discontinued and replaced with ramipril for blood pressure control. During follow-up, the skin lesions showed marked improvement. However, the patient developed similar cutaneous manifestations again when SV was re-administered. He had previously developed psoriasis while using nifedipine, but transitioned to olmesartan and subsequently improved significantly with topical medication. Sacubitril enhances the effect of natriuretic peptides, which may be accompanied by a compensatory increase in angiotensin Ⅱ (Ang Ⅱ) levels, possibly contributing to the psoriasis. To the best of our knowledge, this is the first reported case worldwide of psoriasis potentially associated with SV, and the underlying mechanism appears likely to be related to sacubitril. It serves as a caution for clinicians prescribing SV, particularly in patients with a history of psoriasis or positivity for the HLA-Cw*0602 allele. Further studies are warranted to confirm the mechanism by which sacubitril induces psoriasis.<p><a href="http://europepmc.org/article/MED/42177422?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">628</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Association of Body Roundness Index, Lipid Accumulation Product, and Triglyceride-Glucose Index With Psoriasis: A Systematic Review of Observational Studies.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/association-of-body-roundness-index-lipid-accumulation-product-and-triglyceride-glucose-index-with-psoriasis-a-systematic-review-of-observational-studies-r627/</link><description><![CDATA[<h4>Background and aims</h4>Lipid dysregulation plays a crucial role in psoriasis pathogenesis and its cardiometabolic comorbidities. Novel anthropometric indices such as Body Roundness Index (BRI), Lipid Accumulation Product (LAP), and Triglyceride-Glucose (TyG) index have been proposed to better reflect underlying metabolic dysfunction and may be associated with psoriasis risk, severity, and related complications. This systematic review evaluates the current evidence on the associations of BRI, LAP, and the TyG index with psoriasis and related clinical outcomes.<h4>Methods</h4>A comprehensive literature search was conducted from inception up to September 2025. Observational studies examining the relationship between BRI, LAP, or TyG index and psoriasis or its clinical outcomes were included. Data synthesis comprised qualitative and descriptive statistical analyses.<h4>Results</h4>Fifteen studies comprising 65,130 participants from diverse countries met the inclusion criteria. Higher LAP was consistently associated with increased psoriasis risk but showed weak or no correlation with disease severity (PASI). All BRI studies, primarily using US National Health and Nutrition Examination Survey data, demonstrated a positive association between BRI and psoriasis risk, with modest predictive ability (AUC 0.56-0.58). TyG index was linked to adverse metabolic and cardiovascular outcomes, fatty liver disease, and all-cause mortality in psoriasis patients, although correlations with PASI were generally non-significant.<h4>Conclusions</h4>BRI, LAP, and TyG index are consistently associated with psoriasis risk and related metabolic and cardiovascular complications, highlighting their potential utility for early risk stratification and holistic management of psoriasis patients. Further prospective studies are warranted to clarify their predictive value for disease severity and long-term outcomes.<p><a href="http://europepmc.org/article/MED/42157919?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">627</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Novel post-translational modification learning signature reveals DPP3 promotes progression of psoriasis by enhancing inflammatory activation.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/novel-post-translational-modification-learning-signature-reveals-dpp3-promotes-progression-of-psoriasis-by-enhancing-inflammatory-activation-r626/</link><description><![CDATA[Although post-translational modifications (PTMs) significantly influence the pathogenesis of psoriasis, their specific mechanisms remain poorly understood. This study aimed to identify novel PTM-targeted therapeutic avenues for the precision treatment of psoriasis. Nine psoriasis-related datasets GSE13355, GSE14905, GSE30999, GSE41664, GSE51440, GSE53552, GSE54456, GSE117239, and GSE226244 were obtained. Consensus clustering was performed to identify psoriasis subtypes. Then, the study proceeded to pinpoint module genes by leveraging WGCNA. Additionally, the investigation also focused on uncovering hub genes by machine learning. Finally, we investigated the expression and localization of DPP3. A total of 2,141 differentially expressed genes (DEGs) were identified between the control and psoriasis samples. Enrichment analyses revealed that these DEGs are associated with inflammatory pathway involved in the progression of psoriasis. Additionally, two distinct psoriasis subclasses were identified, namely cluster.A and cluster.B. Moreover, 279 module genes related to these subtypes were identified using WGCNA. Then, utilizing the shared DEGs, cluster DEGs, key module genes, and PTM genes, 7 hub genes were obtained. Multiple machine learning models screened 7 key genes, demonstrated excellent diagnostic ability in psoriasis across multiple datasets (Average AUC = 0.901), and outperformed currently utilized diagnostic indicators specific to psoriasis. From a biological standpoint, the analysis revealed significant correlations between PTM.score and various inflammatory parameters. Notably, DPP3 emerged as an essential molecular element, exhibiting higher expression levels in psoriasis. Mechanistically, the overexpression of DPP3 enhances inflammatory activation, which in turn promotes the progression of psoriasis. This research provides genetic evidence supporting the therapeutic potential of targeting DPP3 in the treatment of psoriasis, while also elucidating its underlying pathophysiological mechanisms.<p><a href="http://europepmc.org/article/MED/42173459?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">626</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Studying the expression levels of LncRNA-MEG3 and miR-147b in the serum of psoriasis patients with and without dyslipidemia.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/studying-the-expression-levels-of-lncrna-meg3-and-mir-147b-in-the-serum-of-psoriasis-patients-with-and-without-dyslipidemia-r625/</link><description><![CDATA[Psoriasis is a chronic systemic inflammatory skin disorder that is strongly associated with metabolic disorders, including obesity, insulin resistance, hypertension, and dyslipidemia. Dyslipidemia causes abnormalities in lipid profiles, such as elevated triglycerides or low density lipoprotein (LDL) levels. Measure maternally expressed gene 3 (MEG3) and microRNA-147b in serum of patients with and without dyslipidemia compared to healthy control. These measurements were compared with clinical characteristics, clinical parameters, and laboratory investigations. Serum expression levels of MEG3 and microRNA-147b, as non-coding RNA biomarkers, were measured across four equally subcategorized groups (patients with and without dyslipidemia (N = 66) and healthy controls with and without dyslipidemia (N = 66) using Polymerase Chain Reaction (PCR). Psoriatic patients exhibited a high significantly body mass index and elevated low-density lipoprotein levels compared with controls (p = 0.038,0.010) respectively, while fasting blood glucose was significantl at p = 0.001. Fasting blood glucose and lipid parameters showed low levels in patients without dyslipidemia and high levels of high-density lipoprotein than those with dyslipidemia. Expression Level of MEG3 was significantly downregulated, whereas microRNA-147b was markedly upregulated in psoriatic patients (p &lt; 0.0001). MEG3 expression was negatively correlated with disease severity indices and lipid levels and inversely correlated with microRNA-147b, which also negatively correlated with disease duration. MEG3 and miR-147b, as non-coding RNAs, may show differential expression among psoriasis patient subgroups and could be associated with disease-related parameters, but their value as markers of disease severity or prognosis remains to be confirmed.<p><a href="http://europepmc.org/article/MED/42156472?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">625</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item><item><title>Correction: Association between Life's Essential 8 and psoriasis in US adults: a cross-sectional study</title><link>https://www.psoriasis-news.de/articles.html/1_articles/correction-association-between-lifes-essential-8-and-psoriasis-in-us-adults-a-cross-sectional-study-r624/</link><description><![CDATA[<small>No abstract supplied.</small><p><a href="http://europepmc.org/article/PMC/PMC13188854?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">624</guid><pubDate>Mon, 25 May 2026 08:01:40 +0000</pubDate></item></channel></rss>
