<?xml version="1.0"?>
<rss version="2.0"><channel><title>Neue Studien: Europe PMC</title><link>https://www.psoriasis-news.de/articles.html/1_articles/page/9/?d=1</link><description>Neue Studien: Europe PMC</description><language>de</language><item><title>Biologics and small molecules for psoriasis: current and future progress.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/biologics-and-small-molecules-for-psoriasis-current-and-future-progress-r367/</link><description><![CDATA[Advances in the understanding of the pathophysiology of psoriasis have led to the development of biologic therapies that target key components of the immune system involved in the inflammatory cascade of psoriasis, revolutionizing the management of moderate-to-severe cases. Alongside biologics, small molecules have emerged as promising treatment options. However, despite significant progress, several challenges remain. Additionally, long-term safety data for many newer agents are still lacking, necessitating ongoing surveillance and real-world evidence collection. This narrative review, performed by analysing the existing medical literature using PubMed, Ovid, Scopus, Embase and Cochrane Library databases up to 30 June 2025, explores new systemic therapies for psoriasis, including both approved and emerging biologics and small molecules, highlighting future directions in treatment. Despite advancements in psoriasis treatment, unmet needs persist, including specific clinical phenotypes such as pustular psoriasis, paradoxical reactions, patient comorbidities, treatment resistance or inefficacy, and high costs, underscoring the need for novel and emerging therapies. In the future, advances in pharmacogenetics and artificial intelligence could revolutionize psoriasis management. Artificial intelligence-driven models integrating clinical data, laboratory findings and biomarkers could enhance precision medicine by optimizing treatment selection and establishing standardized therapeutic algorithms, ensuring that patients receive the right drug at the right time.<p><a href="http://europepmc.org/article/MED/41312187?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">367</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Patient Experiences on the Diagnosis, Management, and Burden of Generalized Pustular Psoriasis: An International Web Survey and Qualitative Interview Study</title><link>https://www.psoriasis-news.de/articles.html/1_articles/patient-experiences-on-the-diagnosis-management-and-burden-of-generalized-pustular-psoriasis-an-international-web-survey-and-qualitative-interview-study-r366/</link><description><![CDATA[<small>No abstract supplied.</small><p><a href="http://europepmc.org/article/PMC/PMC12657205?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">366</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Consensus definitions of complex-to-manage and treatment-refractory psoriatic arthritis: a GRAPPA initiative.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/consensus-definitions-of-complex-to-manage-and-treatment-refractory-psoriatic-arthritis-a-grappa-initiative-r365/</link><description><![CDATA[Despite advances in the treatment of psoriatic arthritis (PsA), a substantial proportion of patients continue to report persistent symptoms and impaired quality of life. However, terminology remains inconsistent for patients who fail to achieve disease control despite treatment, which limits research comparability and contributes to therapeutic inertia. To address this gap, a Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) task force developed consensus definitions for two distinct states: complex-to-manage PsA (C2M-PsA) and treatment-refractory PsA (TR-PsA). C2M-PsA is defined as a state of persistent symptoms despite treatment with at least one biologic or targeted synthetic DMARD (b/tsDMARD), extending beyond biological non-response to include factors such as comorbidities, overlapping conditions, psychosocial burden and treatment-related challenges (for example, non-adherence). TR-PsA, a more specific subset of C2M-PsA, is characterized by failure of at least three therapies with distinct mechanisms of action (including at least two biologic/targeted synthetic DMARDs), persistent symptoms considered problematic by both patient and clinician, and objective evidence of ongoing inflammation - after ruling out alternative explanations for treatment refractoriness. These consensus-derived GRAPPA definitions provide a shared framework to standardize terminology, support individualized care, and improve patient stratification in research and practice. Prospective validation across diverse settings and phenotypes is needed to confirm their reliability, responsiveness and clinical utility.<p><a href="http://europepmc.org/article/MED/41310208?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">365</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Psoriasis treatment training in dermatology residency: a Latin American survey of faculty and residents.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/psoriasis-treatment-training-in-dermatology-residency-a-latin-american-survey-of-faculty-and-residents-r364/</link><description><![CDATA[<h4>Objective</h4>This study evaluated psoriasis treatment teaching in dermatology residency programs across Latin America (LATAM).<h4>Methods</h4>A Spanish/Portuguese survey was distributed to directors of dermatology departments/training programs and their residents in several LATAM countries between November 29, 2022, and March 31, 2023.<h4>Results</h4>A total of 108 individuals responded (59 directors and 49 residents) from eight countries: Argentina (2.8%), Brazil (41.7%), Chile (25.0%), Colombia (7.4%), Guatemala (1.9%), Mexico (1.9%), Paraguay (4.6%), and Peru (14.8%). Most directors reported that residents received training in complex medical dermatology (89.8%), immunodermatology (66.1%), and phototherapy (78%). Most residents reported familiarity with national guidelines (81.6%) and adherence to local guidelines (85.7%). In Brazil, 91% of programs had at least seven faculty members, 97% required national specialization exams, and 91% treated more than 31 psoriasis patients per week, compared with 48%, 36%, and 67% in other LATAM countries, respectively. Additionally, 47% of centers in Brazil reported that at least 26% of psoriasis patients received biological therapy, compared with only 8% in other LATAM countries.<h4>Conclusion</h4>Dermatology residents in LATAM are trained in complex dermatology, immunodermatology, and phototherapy and national psoriasis guidelines. Variation exists in patient volume and biologics use. A focus on improving residents' psoriasis training throughout LATAM is needed.<p><a href="http://europepmc.org/article/MED/41311050?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">364</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Screening of key genes related to disulfidptosis in psoriasis based on the analysis of WGCNA.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/screening-of-key-genes-related-to-disulfidptosis-in-psoriasis-based-on-the-analysis-of-wgcna-r363/</link><description><![CDATA[Psoriasis features keratinocyte hyperproliferation. This study aimed to identify disulfidptosis-related key genes in psoriasis for potential diagnostic biomarkers or therapeutic targets. Using the GSE30999 dataset, WGCNA was applied to identify key gene modules. GO, KEGG were used for analysis. IHC, Western blot, PCR and free thiol tests verified results. WGCNA clustered differentially expressed genes into 18 modules, with the blue module being significantly associated with psoriasis (Pearson's r = 0.82, P &lt; 0.001). Six hub genes (FRK, GYS1, HECW2, MYH10, S100A12, SLC7A11) were identified. GYS1, S100A12, and SLC7A11 showed pronounced dysregulation (FDR &lt; 0.01) and upregulation in psoriasis epidermis (P &lt; 0.05). The double-stranded death core pathogenic gene SLC7A11 can regulate the level of free sulfhydryl groups and the expression levels of molecules in the NF-κB pathway.(P &lt; 0.05). GYS1, S100A12, and SLC7A11 are disulfidptosis-related driver genes in psoriasis, aiding molecular diagnosis and treatment.<p><a href="http://europepmc.org/article/MED/41315413?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">363</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Dysbiosis of the Saliva Microbiota in Patients with Psoriasis: A Case-Control Study.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/dysbiosis-of-the-saliva-microbiota-in-patients-with-psoriasis-a-case-control-study-r362/</link><description><![CDATA[<h4>Purpose</h4>Accumulating evidence supports the association between altered salivary microbiota and inflammatory diseases. The existing literature on the salivary microbiota in patients with psoriasis is limited. However, differences in the prevalence of <i>Candida</i> species and abundance of several bacterial taxa in saliva have been found between patients and controls. This study aimed to investigate the differences in the composition and functional potential of salivary microbiota in patients with psoriasis compared to their cohabiting partners and healthy controls.<h4>Patients and methods</h4>Samples from 115 of 123 individuals qualified for statistical analysis: patients with psoriasis who did not receive systemic anti-psoriatic treatment (n=47); cohabiting partners (n=21); and age-, sex-, and BMI-matched healthy controls (n=47). One saliva sample was collected from each participant and analysed by shotgun metagenomic sequencing.<h4>Results</h4>A difference in the α-diversity of bacterial species was observed exclusively between patients and controls, with a lower diversity in patients (p=0.041). Variation in bacterial composition (β-diversity) was influenced by smoking (p=0.001) and diet (p=0.025) but not by group status. Using a linear regression model adjusted for smoking and diet, we identified four bacterial classes and five species that were significantly different between the patient, partner, and control groups. One Kyoto Encyclopedia of Genes and Genomes module differed significantly between patients with psoriasis and their partners. No differences in <i>Candida</i> species or abundance were found among the three groups.<h4>Conclusion</h4>Comparison of salivary microbiota at the levels of bacterial diversity, composition, and predicted function indicated that psoriasis cases are characterised by dysbiosis.<p><a href="http://europepmc.org/article/MED/41306730?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">362</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>TNF-&#x3B1;-Driven Systemic Inflammasome Hyperactivity Links Psoriatic Inflammation to monocyte inflammatory response and platelet activation</title><link>https://www.psoriasis-news.de/articles.html/1_articles/tnf-%CE%B1-driven-systemic-inflammasome-hyperactivity-links-psoriatic-inflammation-to-monocyte-inflammatory-response-and-platelet-activation-r361/</link><description><![CDATA[<h4>ABSTRACT</h4>  <h4>Background</h4>  Psoriasis is a chronic skin disease mediated by Th1 and Th17 immune responses and is classified as a systemic inflammatory disorder. Notably, psoriasis is an independent risk factor for myocardial infarction, stroke, and cardiovascular mortality, particularly in severe disease. However, the cellular mechanisms linking psoriasis to cardiovascular disease risk have not yet been identified. To address this gap, we investigated systemic markers of inflammasome signaling and innate immune activation in patients with psoriasis. <h4>Methods</h4>  Whole blood was collected from 43 patients, including active psoriasis (mild-to-moderate disease) without clinical manifestations of atherosclerosis, inactive psoriasis (minimal disease activity), patients receiving anti-TNF-α therapy, and 19 BMI-matched healthy controls. Multiparametric spectral flow cytometry was performed to profile inflammasome signaling, and mass spectrometry-based proteomics was used to obtain unbiased phenotyping of circulating immune cells. <h4>Results</h4>  Classical monocytes from patients with active psoriasis exhibited heightened NLRP3 protein expression and caspase-1 activity upon brief physiological stimulation, responses absent in inactive psoriasis and healthy controls. Mechanistically, active psoriasis demonstrated elevated plasma ATP and increased monocyte expression of P2X7R, a potent NLRP3 activator. TNF-α was identified as a key cytokine, selectively upregulating both P2X7R and NLRP3. Baseline proteomics revealed enriched pathways for monocyte extravasation and cell adhesion, suggesting a pro-thrombotic state. Stimulation increased proteins linked to ROS and mitochondrial stress. Monocytes from active psoriasis exhibited increased baseline activation and, upon stimulation, enhanced monocyte-platelet aggregation, both of which were attenuated by inhibition of mitochondrial ROS. Importantly, anti-TNF therapy normalized ATP levels, P2X7R expression, inflammasome responsiveness, monocyte activation, and monocyte-platelet interactions, supporting the restoration of systemic immune homeostasis. <h4>Conclusions</h4>  In patients with mild-to-moderate psoriasis, we demonstrate persistent systemic stress, resulting in inflammasome hyperreactivity and increased monocyte-platelet aggregation in response to minor perturbations in cellular homeostasis. Notably, TNF-α blockade restores these effects, providing mechanistic insight into how anti-TNF therapy reduces systemic inflammation and cardiovascular risk. <h4>What is already known about this topic?</h4>  Psoriasis is a systemic, immune-mediated skin disease that is associated with an increased risk of cardiovascular disease (CVD), particularly in severe disease. The NLRP3 inflammasome, an innate immune sensor, has been implicated in the pathogenesis of CVD. Anti-TNF therapy, which is effective in treating psoriasis, is proposed to reduce CVD risk, but the underlying mechanisms remain unclear. <h4>What does this study add?</h4>  Patients with mild-to-moderate psoriasis without clinical manifestations of atherosclerosis demonstrate elevated plasma ATP levels, increased monocyte P2X7 receptor expression, and enriched pathways for monocyte activation and extravasation, suggesting persistent systemic stress. Monocytes from these patients display ROS-dependent hyperactivation of the NLRP3 inflammasome and increased formation of monocyte-platelet aggregates in response to minor perturbations in cellular homeostasis. TNF-α was identified as a key cytokine, selectively upregulating both P2X7R and NLRP3. Anti-TNF therapy normalized these aberrant immune responses, suggesting a mechanism for its proposed cardioprotective effects. <h4>Novelty and significance</h4>  This study provides evidence that patients with mild to moderate psoriasis, without clinical manifestations of atherosclerosis, exhibit concurrent elevations in plasma ATP levels, monocyte P2X7 receptor expression, inflammasome responsiveness, and monocyte-platelet aggregates: features increasingly associated with CVD risk. These findings suggest that dysregulated purinergic signaling may contribute to systemic immune activation in psoriasis. Importantly, anti-TNF therapy was associated with normalization of these parameters, pointing toward a potential immunomodulatory mechanism by which such treatment may help reduce CVD risk. These observations highlight a novel intersection between inflammation, purinergic signaling, and monocyte-platelet activation, which may contribute to the increased CVD risk in psoriasis.<p><a href="http://europepmc.org/article/PPR/PPR1125843?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">361</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Impact of adalimumab treatment on impairment of non-professional activities in psoriasis patients.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/impact-of-adalimumab-treatment-on-impairment-of-non-professional-activities-in-psoriasis-patients-r360/</link><description><![CDATA[<h4>Background and objectives</h4>Psoriasis can result in reduced quality of life, work productivity loss, and a significant restriction in non-professional activities. This study investigates the effects of long-term treatment with adalimumab regarding work ability, non-professional activities, and health-related quality of life in a large real-word population in Germany.<h4>Patients and methods</h4>Single-arm, multicenter non-interventional study to document routine care data for up to 5 years in adult patients with psoriasis after initiation of adalimumab.<h4>Results</h4>Baseline data was collected for 4,793 (62.1 % male) patients with a mean (± SD) age of 47.5 ± 13.11 years. The number of days with restrictions in non-professional activities was much higher than in professional activities. Under adalimumab, the psoriasis-related number of days unfit for work and number of days with restrictions in non-professional activities significantly decreased. Correlation analyses showed that psoriatic arthritis, disease severity (PASI &gt; 10), and impairment of quality of life (DLQI &gt; 10) are associated with restrictions in non-professional activities. Health-related quality of life improved over the observed time but remained reduced in patients with restrictions in non-professional activities.<h4>Conclusions</h4>Long-term treatment with adalimumab had a favorable impact on clinical outcomes, employment-related aspects, practice of non-professional activities, and health-related quality of life in psoriasis patients.<p><a href="http://europepmc.org/article/MED/41312671?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">360</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Psychiatric evaluation and personality in psoriasis patients.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/psychiatric-evaluation-and-personality-in-psoriasis-patients-r359/</link><description><![CDATA[Psoriasis is a chronic inflammatory, autoaggressive disease. It is known that psychiatric comorbidity in psoriasis contributes to the progression and exacerbation of the disease. This study aims to examine psychiatric disorders and personality traits in a sample of patients with psoriasis. Personal information forms, General Health Questionnaire (GHQ-12), Hospital-Anxiety-Depression Scale (HADS), Five-Factor Personality Inventory Short Form (BFI) were used for all participants. Psoriasis patients were evaluated with clinical information form, Dermatology Life Quality Index (DLQI), and psoriasis-area-severity-index (PASI). Psychiatric disorders were investigated with the Structured-Clinical-Interview for DSM-IV (SCID) diagnosis. A total of 129 participants completed the case-control study. Psoriasis patients' HADS-total score showed positive correlation with the PASI and DLQI score. SCID interview was conducted with 39(66.1%) psoriasis patients with GHQ-12 score of ≥2, and 25 patients (42.4%) received at least one psychiatric diagnosis. Conscientiousness, agreeableness, and stability were higher in patients with psoriasis than in healthy controls. In psoriasis patients with a psychiatric diagnosis, Plasticity, and Openness to experience personality traits scores showed a significant decrease with a medium effect size. In psoriasis patients without a psychiatric diagnosis, high stability scores were associated with positive emotionality and social well-being, while low plasticity levels were determined as predictors of psychopathology. In improving the quality of life of psoriasis patients, it is important to plan effective treatments for both psoriasis and psychopathology and to evaluate biological vulnerabilities such as personality traits in terms of the risk of comorbid psychopathology. In psoriasis patients with a psychiatric diagnosis, Plasticity, and Openness to Experience personality traits scores showed a significant decrease with a medium effect size.Plasticity predicted psychiatric diagnosis significantly, and negatively in psoriasis patients.In psoriasis patients without a psychiatric diagnosis, high stability scores were associated with positive emotionality and social well-being, while low plasticity levels were determined as predictors of psychopathology.<p><a href="http://europepmc.org/article/MED/41318976?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">359</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Anterior Extrusion of an Orthobiologic Sacroiliac Joint Implant in a Patient With Psoriatic Arthritis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/anterior-extrusion-of-an-orthobiologic-sacroiliac-joint-implant-in-a-patient-with-psoriatic-arthritis-r358/</link><description><![CDATA[<h4>Background</h4>Sacroiliac joint (SIJ) pain accounts for a large portion of low back pain within the population. Management for this SIJ pain consists of many non-invasive treatments including physical therapy, nerve ablation, intra-articular SIJ injections, bracing, and manipulative therapy. Pain that proves to be resistant to these modalities has previously been considered for surgical stabilization through a transiliac approach, which involves placement of screws.<h4>Aims</h4>To describe the anterior extrusion of a SIJ implant following arthrodesis, which is a unique complication of a minimally invasive SIJ fusion via the posterior approach.<h4>Materials and methods</h4>A 52 year old female with a past medical history of psoriatic arthritis and alanto-axial instability presented with a year-long history of bilateral lower back and right-sided posterior thigh and buttock pain. Evaluation included lumbar MRI and pelvic CT. Based on these findings, she underwent minimally invasive posterior SIJ fusion using the LinQ allograft. Her symptoms and response to treatment were documented throughout her clinic follow-ups.<h4>Results</h4>Imaging revealed degenerative SIJ changes. She subsequently underwent several rounds of SIJ steroid injections. Due to continued pain, she opted to have a minimally invasive SIJ fusion via the posterior approach, first on the right side and then on the left side. After several months of persistent, reaggravated SIJ pain, a repeat pelvic CT showed anterior extrusion of the right SIJ allograft.<h4>Discussion</h4>More recently, multiple minimally invasive techniques for SIJ fusions have been developed, one of them being posterior insertion of an orthobiologic implant. Minimally invasive SIJ fusion has been shown to provide pain relief and decrease disability. Posterior implant insertion to partially fuse the SIJ carries minimal risk of complications, one of which is posterior dislodgment of the implant. However, anterior extrusion of the implant has not, to our knowledge, been described or reported.<p><a href="http://europepmc.org/article/MED/41312897?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">358</guid><pubDate>Sun, 30 Nov 2025 16:48:11 +0000</pubDate></item><item><title>Psoriatic Arthritis: From Diagnosis to Treatment.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/psoriatic-arthritis-from-diagnosis-to-treatment-r357/</link><description><![CDATA[Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory arthritis associated with psoriasis, affecting joints, entheses, and the axial skeleton. While primary care providers and dermatologists frequently encounter psoriasis (PsO), early recognition of PsA remains critical to preventing irreversible joint damage. This paper is written to provide a comprehensive overview of PsA, beginning with a clinical case that highlights diagnostic and therapeutic challenges. In this review, the epidemiology of PsA will be discussed, emphasizing its prevalence and risk factors among patients with PsO. The discussion extends to the underlying pathogenesis, focusing on genetic predisposition, environmental triggers, and key cytokines, including TNF-α, IL-17, and IL-23, that have become targets for advanced therapeutics. The clinical features of PsA are explored in detail, including peripheral and axial arthritis, enthesitis, dactylitis, and extra-articular manifestations. Diagnostic approaches are discussed, with a focus on the Classification Criteria for Psoriatic Arthritis (CASPAR) and Moll &amp; Wright criteria. Additionally, we examine screening tools designed to facilitate early detection in dermatology clinics. Diagnostic modalities, including imaging and serologic markers, are reviewed. Finally, we explore the evolving landscape of PsA treatment, spanning conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), biologic agents (bDMARDs), and targeted synthetic DMARDs (tsDMARDs). Given the increasing availability of cytokine-targeted therapies, an interdisciplinary approach between dermatologists and rheumatologists is essential for optimizing outcomes in PsA patients. Patients with PsA are cared for by rheumatologists, dermatologists, and primary care providers who help manage the comorbidities associated with PsA. By bridging primary care, dermatology, and rheumatology in the care of PsA, this paper aims to enhance understanding of PsA for facilitating early identification and timely intervention for improved patient care.<p><a href="http://europepmc.org/article/MED/41303186?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">357</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Real-world evidence for repurposing hydralazine as a potential epigenetic modulator for psoriasis: a 16-year retrospective nationwide cohort study.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/real-world-evidence-for-repurposing-hydralazine-as-a-potential-epigenetic-modulator-for-psoriasis-a-16-year-retrospective-nationwide-cohort-study-r356/</link><description><![CDATA[<small>No abstract supplied.</small><p><a href="http://europepmc.org/article/MED/41250209?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">356</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Joint Position Statement from the National Psoriasis Foundation Medical Board and the International Psoriasis Council on Routine Testing for Latent Tuberculosis Infection Prior To and During Treatment of Psoriasis Patients with IL-17 or IL-23 Inhibitors.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/joint-position-statement-from-the-national-psoriasis-foundation-medical-board-and-the-international-psoriasis-council-on-routine-testing-for-latent-tuberculosis-infection-prior-to-and-during-treatment-of-psoriasis-patients-with-il-17-or-il-23-inhibitors-r355/</link><description><![CDATA[<h4>Background</h4>Although testing for latent tuberculosis (TB) infection has been standard practice for psoriasis patients being treated with IL-17 or IL-23 inhibitors, evidence for this practice is weak.<h4>Objectives</h4>To review evidence on safety of IL-17 and IL-23 inhibitors in the setting of latent TB infection, and to provide a new Joint Position Statement on this topic.<h4>Methods</h4>Experts from the National Psoriasis Foundation (NPF) and the International Psoriasis Council (IPC) reviewed evidence regarding progression of latent TB infection to active disease in psoriasis patients receiving IL-17 or IL-23 blockers. A Joint Position Statement was formulated and approved to provide updated guidance to clinicians.<h4>Results</h4>87.5% of the members from the NPF Medical Board and IPC approved a new Joint Position Statement regarding psoriasis patients being treated with IL-17 or IL-23 inhibitors, stating that testing for latent TB infection is not required.<h4>Limitations</h4>This position statement allows for exceptions where continued testing for latent TB infection could be considered, including for patients on concomitant immunosuppressive therapy and for those living in TB endemic areas.<h4>Conclusion</h4>Psoriasis experts reached consensus that routine testing for latent TB infection is not required in psoriasis patients being treated with IL-17 or IL-23 inhibitors.<p><a href="http://europepmc.org/article/MED/41260526?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">355</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Switching from Intravenous to Subcutaneous Infliximab Maintains Efficacy and Enhances Treatment Satisfaction in Patients with Psoriasis</title><link>https://www.psoriasis-news.de/articles.html/1_articles/switching-from-intravenous-to-subcutaneous-infliximab-maintains-efficacy-and-enhances-treatment-satisfaction-in-patients-with-psoriasis-r354/</link><description><![CDATA[<h4>Background: </h4> /Objectives: Plaque psoriasis is a chronic immune-mediated inflammatory disease affecting approximately 3% of the global population and resulting in a significant deterioration in quality of life. Systemic therapy with monoclonal antibodies (mAbs) targeting TNF-α, IL-23, and IL-17 improves clinical outcomes and patients’ quality of life. Treatment strategies commonly include different mAbs and different sequencings approaches between agents, which are well-established in clinical practice. In contrast, evidence supporting the switch from intravenous to subcutaneous administration of the same mAb remains limited. Herein, we report data from a retrospective case series of patients with plaque psoriasis treated with intravenous infliximab (IV-IFX; Anti TNF-α) and transitioned to subcutaneous infliximab (SC-IFX) to compare clinical and patient-reported outcomes across routes. <h4>Methods:</h4> 11 plaque psoriasis patients were retrospectively analyzed. The scores of Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI) and Physician Global Assessment (PGA) were assessed during IV-IFX and after switching to SC-IFX. To evaluate patients’ satisfaction, the Score of Treatment Satisfaction Questionnaire Medication-9 (TSQM-9) was evaluated. Both Student’s t-test and ANOVA were used to assess statistically significant differences between the two routes of administration (p&amp;lt;0.05). <h4>Results:</h4> scores for PASI, DLQI and PGA were lower with SC-IFX compared to IV-IFX, indicating improved disease control and quality of life after the switch. PASI and DLQI improved in 81% and 100% of patients treated with SC-IFX, respectively. TSQM-9 total scores increased significantly by 24% (P&amp;lt;0.001). In particular, the questions addressing the “convenience” of treatment, revealed a marked advantage for the SC-IFX formulation (p&amp;lt;0.001). No treatment-emergent adverse events were registered. <h4>Conclusions:</h4> In this retrospective case series, switching from IV-IFX to SC-IFX appeared to be safe and to maintain or improve clinical response and enhanced treatment satisfaction. Thus, these findings highlight the potential of SC-IFX as a viable maintenance option for patients with plaque psoriasis previously treated with IV-IFX.<p><a href="http://europepmc.org/article/PPR/PPR1126022?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">354</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Burden of immune-related skin diseases worldwide, 1991&#x2013;2021: insights and prediction from the Global Burden of Disease Study</title><link>https://www.psoriasis-news.de/articles.html/1_articles/burden-of-immune-related-skin-diseases-worldwide-19912021-insights-and-prediction-from-the-global-burden-of-disease-study-r353/</link><description><![CDATA[<small>No abstract supplied.</small><p><a href="http://europepmc.org/article/PMC/PMC12644009?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">353</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>TNF-&#x3B1;-Driven Systemic Inflammasome Hyperactivity Links Psoriatic Inflammation to monocyte inflammatory response and platelet activation</title><link>https://www.psoriasis-news.de/articles.html/1_articles/tnf-%CE%B1-driven-systemic-inflammasome-hyperactivity-links-psoriatic-inflammation-to-monocyte-inflammatory-response-and-platelet-activation-r352/</link><description><![CDATA[Psoriasis is a chronic skin disease mediated by Th1 and Th17 immune responses and is classified as a systemic inflammatory disorder. Notably, psoriasis is an independent risk factor for myocardial infarction, stroke, and cardiovascular mortality, particularly in severe disease. However, the cellular mechanisms linking psoriasis to cardiovascular disease have not yet been identified. To address this gap, we investigated systemic markers of inflammasome signaling and innate immune activation in patients with psoriasis. Whole blood was collected from 43 patients, including active psoriasis (mild-to-moderate disease) without clinical manifestations of atherosclerosis, inactive psoriasis (minimal disease activity), patients receiving anti-TNF-α therapy, and 19 BMI-matched healthy controls. Multiparametric spectral flow cytometry was performed to profile inflammasome signaling, and mass spectrometry-based proteomics was used to obtain unbiased phenotyping of circulating immune cells.  Classical monocytes from patients with active psoriasis exhibited heightened NLRP3 protein expression and caspase-1 activity upon brief physiological stimulation, responses absent in inactive psoriasis and healthy controls. Mechanistically, active psoriasis demonstrated elevated plasma ATP and increased monocyte expression of P2X7R, a potent NLRP3 activator. TNF-α was identified as a key cytokine, selectively upregulating both P2X7R and NLRP3. Baseline proteomics revealed enriched pathways for monocyte extravasation and cell adhesion, suggesting a pro-thrombotic state. Stimulation increased proteins linked to ROS and mitochondrial stress. Monocytes from active psoriasis exhibited increased baseline activation and, upon stimulation, enhanced monocyte-platelet aggregation, both of which were attenuated by inhibition of mitochondrial ROS. Importantly, anti-TNF therapy normalized ATP levels, P2X7R expression, inflammasome responsiveness, monocyte activation, and monocyte-platelet interactions, supporting the restoration of systemic immune homeostasis.  In patients with mild-to-moderate psoriasis, we demonstrate persistent systemic stress, resulting in inflammasome hyperreactivity and increased monocyte-platelet aggregation in response to minor perturbations in cellular homeostasis. Notably, TNF-α blockade restores these effects, providing mechanistic insight into how anti-TNF therapy reduces systemic inflammation and cardiovascular risk.<p><a href="http://europepmc.org/article/PPR/PPR1125843?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">352</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Sternoclavicular joint involvement in psoriatic arthritis: a hidden indicator of disease severity.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/sternoclavicular-joint-involvement-in-psoriatic-arthritis-a-hidden-indicator-of-disease-severity-r351/</link><description><![CDATA[<h4>Objectives</h4>Sternoclavicular joint (SCJ) involvement in psoriatic arthritis (PsA) is poorly characterized. We aimed to assess its prevalence and clinical associations in a longitudinal PsA cohort.<h4>Methods</h4>We retrospectively analyzed prospectively collected data from the Gladman Krembil Psoriatic Arthritis Program. Patients with SCJ involvement (tender and/or swollen SCJ) were identified, and their demographic, clinical, laboratory, and treatment details were retrieved. Univariable and multivariable generalized estimating equation models were used to assess associations with clinically swollen SCJ. Results are reported as odds ratios (OR) with 95% confidence intervals (CI).<h4>Results</h4>Among 1,737 patients, 182 (10.5%) had SCJ involvement, including 36 (2.1%) with clinically swollen SCJs ever over follow-up. SCJ involvement was present at enrolment into the cohort (baseline) in 33.1% of affected individuals. The mean age was 41.4 ± 12 years, and 42% were male. In univariable analyses, SCJ involvement was significantly associated with higher swollen joint count (SJC) (OR 1.142, 95% CI 1.08-1.16), dactylitis (4.51, 2.02-10.05), and enthesitis (6.74, 3.45-13.15). No significant associations were observed with sex, disease duration, axial and nail disease, PASI, pustular psoriasis, or HLA markers. In multivariable analysis, SCJ swelling remained associated with higher SJC (1.08, 1.03-1.14), enthesitis (4.54, 1.98-10.45), dactylitis (4.54, 1.98-10.45) and lower biologic or targeted synthetic DMARD use (0.30, 0.10-0.88).<h4>Conclusion</h4>SCJ involvement is an underrecognized but clinically meaningful manifestation of PsA, associated with greater disease burden and enthesitis, often requiring escalation to advanced therapies.<p><a href="http://europepmc.org/article/MED/41284674?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">351</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Comparing the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin for psoriasis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/comparing-the-effectiveness-and-drug-persistence-of-methotrexate-cyclosporine-and-acitretin-for-psoriasis-r350/</link><description><![CDATA[<h4>Background</h4>Conventional systemic agents remain the cornerstone treatment for psoriasis because of their availability and cost-effectiveness. However, few studies have compared the effectiveness and drug persistence of these agents in Asian populations.<h4>Objectives</h4>To evaluate the effectiveness and drug persistence of methotrexate, cyclosporine, and acitretin, and to identify factors associated with these outcomes.<h4>Methods</h4>We reviewed data from 338 psoriasis patients treated with methotrexate, cyclosporine, or acitretin.<h4>Results</h4>Out of 473 treatment courses, 239 (50.5%) involved methotrexate, 123 (26%) involved acitretin, and 111 (23.5%) involved cyclosporine. After 1 year, the proportion of patients who achieved absolute Psoriasis Area and Severity Index (PASI) ≤ 2 was greater with methotrexate (30.6%) and cyclosporine (22.2%) than with acitretin (9.5%). For absolute PASI ≤ 4, methotrexate (57%) and cyclosporine (47.2%) showed greater effectiveness than did acitretin (34.9%), with a significant difference only between methotrexate and acitretin (<i>P</i> = .017). The effectiveness findings were consistent in both the 1- and 3-year analyses. Multivariate analysis revealed that a high baseline PASI score significantly reduced the effectiveness of both methotrexate and cyclosporine. For methotrexate, a high body mass index was also associated with reduced effectiveness, whereas for acitretin, scalp involvement and male sex were key factors. Methotrexate demonstrated the longest drug survival at 1 year. Higher ages at psoriasis onset and systemic treatment-naive status were correlated with longer drug survival. Conversely, a higher body mass index and psychiatric comorbidities were linked to shorter survival.<h4>Limitations</h4>Methotrexate is typically the first-line systemic therapy in Thailand, which may underestimate the true efficacy of cyclosporine and acitretin when used subsequently.<h4>Conclusion</h4>Methotrexate was more effective and persistent than were cyclosporine and acitretin in a real-world setting.<p><a href="http://europepmc.org/article/MED/41278415?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">350</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Reduction of impairment of sexual activity in patients with genital psoriasis treated with risankizumab: interim results of a real-world study.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/reduction-of-impairment-of-sexual-activity-in-patients-with-genital-psoriasis-treated-with-risankizumab-interim-results-of-a-real-world-study-r349/</link><description><![CDATA[Psoriasis involving the genital region (GenPsO) is associated with impaired quality of life (QoL), including sexual burden and avoidance of sexual intercourse. There is limited data on the effectiveness of risankizumab in GenPsO on patients' QoL and sexual impairment. GPS-Best, a nested cohort non-interventional study within the German Psoriasis registry PsoBest, aims to evaluate the effectiveness of risankizumab in GenPsO and its impact on QoL and sexual impairment. This interim analysis involves 52 patients who completed week 16 of the 52-week GPS-Best study. Patient questionnaires, including the Genital Psoriasis Symptoms Scale (GPSS) and Genital Psoriasis Sexual Impact Scale (GPSIS), were evaluated in patients with plaque psoriasis and a static physician's global assessment of genitalia ≥ 3 at baseline. The results demonstrated a significant reduction in the GPSS total score from a median [IQR] of 42.0 [36.0-57.0] at baseline to 3.0 [0-9.0] at week 16 (<i>p</i> &lt; 0.001). In the GPSIS avoidance and impact subscale, more patients reported 'never' avoiding sexual activity at week 16 compared to baseline (46.8% vs. 10.5%) and 78.9% reported 'no or very low' impact compared to 18.5% at baseline, respectively. These findings indicate risankizumab significantly reduces patient-reported GenPsO symptoms over a 16-week period and increases sexual QoL.<p><a href="http://europepmc.org/article/MED/41307151?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">349</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>Temporarily induced facial eczema by IL-17 inhibitors: a case report and literature review</title><link>https://www.psoriasis-news.de/articles.html/1_articles/temporarily-induced-facial-eczema-by-il-17-inhibitors-a-case-report-and-literature-review-r348/</link><description><![CDATA[<small>No abstract supplied.</small><p><a href="http://europepmc.org/article/PMC/PMC12643843?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">348</guid><pubDate>Fri, 28 Nov 2025 18:56:31 +0000</pubDate></item><item><title>The pivotal role of Interleukin-23 in the skin-gut-joint axis.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/the-pivotal-role-of-interleukin-23-in-the-skin-gut-joint-axis-r346/</link><description><![CDATA[Interleukin-23 (IL-23) plays a pivotal role in the intricate interplay between the skin, gut, and joints, contributing significantly to the pathogenesis of various inflammatory diseases including psoriasis, psoriatic arthritis (PsA), inflammatory bowel disease (IBD) and Behcet's disease. In recent years, several IL-23 inhibitors have been granted approval for the treatment of psoriasis, PsA and IBD. As up to one-third of patients diagnosed with psoriasis may go on to develop PsA and given the strong immunogenetic pathway incrimination of the IL-23 pathway in both psoriasis and PsA, dermatological lead therapy for psoriasis may therefore delay the development of PsA. Furthermore, patients with psoriasis or PsA are associated with increased risk of developing IBD. There is also evidence for psoriasis-directed therapy preventing IBD in keeping with the known pivotal role of IL-23 in both intestinal homeostasis and in the pathogenesis of IBD, including ulcerative colitis and Crohn's disease. This review discusses the multifaceted roles of IL-23 in regulating immune response and maintaining tissue homeostasis within the skin-gut-joint axis. In particular, the use of IL-23 inhibitors in trials in patients with psoriasis, IBD and PsA patients will also be discussed in relation to reverse translational immunology insights around inflammation in these domains.<p><a href="http://europepmc.org/article/MED/41265050?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">346</guid><pubDate>Tue, 25 Nov 2025 19:50:44 +0000</pubDate></item><item><title>Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis</title><link>https://www.psoriasis-news.de/articles.html/1_articles/clinical-benefits-and-complication-profile-of-il-23-inhibitors-in-patients-with-psoriatic-arthritis-a-systematic-review-and-meta-analysis-r345/</link><description><![CDATA[<small>No abstract supplied.</small><p><a href="http://europepmc.org/article/PMC/PMC12631225?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">345</guid><pubDate>Tue, 25 Nov 2025 19:50:44 +0000</pubDate></item><item><title>Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/exploring-the-mechanism-of-notopterygii-rhizoma-et-radix-in-the-treatment-of-psoriasis-using-a-network-pharmacology-approach-and-experimental-validation-r344/</link><description><![CDATA[Psoriasis is a prevalent chronic inflammatory skin disease that significantly reduces patients' quality of life. Current treatments have limited efficacy and severe side effects, necessitating the development of new drugs. Notopterygii rhizoma et radix (Qiang Huo, QH), a Traditional Chinese Medicine (TCM) herb commonly studied for psoriasis patterns and treatment, requires further clarifications of its pharmacological mechanism. This study first verified the therapeutic effects of QH on Imiquimod (IMQ)-induced psoriasis-like mice and LPS-induced keratinocyte (HaCaT) model. Our study showed QH significantly alleviated skin symptoms, improved pathological changes, inhibited HaCaT proliferation, and reduced inflammation. Network pharmacology was then applied to explore QH's potential mechanism, revealing its main effects on phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR), Erbb, and interleukin-17 (IL-17) signaling pathways. Further experiments using IMQ-induced mice and LPS-induced HaCaT model confirmed QH's effects on the PI3K/Akt/mTOR pathway. Notably, this is the first study to demonstrate that QH exerts anti-psoriatic effects via modulation of the PI3K/Akt/mTOR pathway, highlighting its multi-compound, multi-target pharmacological nature. QH relieves psoriasis severity in a "multi-compound and multi-target" manner, providing insight into the application of QH in psoriasis treatment. These findings present mechanistic insights into QH's therapeutic potential and suggest it as a promising multi-target alternative to conventional treatments for psoriasis.<p><a href="http://europepmc.org/article/MED/41253925?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">344</guid><pubDate>Tue, 25 Nov 2025 19:50:44 +0000</pubDate></item><item><title>Coronary Artery Disease Assessment in Psoriasis Patients Well-Controlled Under Systemic Anti-Inflammatory Treatments-A Real-World Observational Study From a Single Center.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/coronary-artery-disease-assessment-in-psoriasis-patients-well-controlled-under-systemic-anti-inflammatory-treatments-a-real-world-observational-study-from-a-single-center-r343/</link><description><![CDATA[Atherosclerosis is now considered to reflect systemic inflammation involving the elevation of multiple proinflammatory cytokines, sharing common underlying pathophysiological mechanisms with psoriasis. There has been increasing interest in whether anti-inflammatory treatment of psoriasis can prevent or halt the progression of atherosclerosis. Here, we conducted a cross-sectional observational clinical study in psoriasis patients with at least one traditional cardiovascular risk factor, such as diabetes, hypertension, or dyslipidemia, and who were being treated with systemic anti-inflammatory drugs. To assess CAD risk, we performed coronary computed tomography angiography (CCTA). We assessed 27 psoriasis patients (14 males/13 females), whose median PASI score was 0 [range, 0-2.3] at the time of CCTA. They had sustained well-controlled psoriasis for a median of 44 months [range, 1-144]. Coronary plaques of varying degrees were detected in 20 patients (74%) by CCTA. Four patients were diagnosed with silent myocardial ischemia (SMI) by invasive coronary angiography (CAG), revealing severe coronary stenosis in major arteries. The severity of coronary plaque burden was significantly associated with male sex, hypertension, and carotid ultrasound abnormalities. Furthermore, notably, we detected a significant positive correlation between the duration of biologic treatment and calcified plaque burden among patients treated with biologic agents for over 6 months. Our study highlights the importance of tight disease control and screening for CAD even in well-controlled psoriasis patients. Further accumulation of studies may lead to better management of CAD risks in this population.<p><a href="http://europepmc.org/article/MED/41277795?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">343</guid><pubDate>Tue, 25 Nov 2025 19:50:44 +0000</pubDate></item><item><title>TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation.</title><link>https://www.psoriasis-news.de/articles.html/1_articles/tgm1-as-a-novel-signature-gene-in-psoriasis-identified-by-integrative-bioinformatics-and-experimental-validation-r342/</link><description><![CDATA[Psoriasis is a systemic immune‑mediated skin disease, typically considered to be incurable. Identification of meaningful biomarkers has been a notable challenge in psoriasis prevention and management. The present study aimed to determine the signature genes driving psoriasis and their underlying mechanism. Microarray datasets of psoriasis were obtained from the Gene Expression Omnibus database, and the differentially expressed genes (DEGs) were identified using the 'limma' R package. Gene Set Enrichment Analysis (GSEA) was performed using the 'clusterProfiler' R tool. Functional and pathway enrichment of DEGs were analyzed using a bioinformatics website (Wei Sheng Xin). Furthermore, the present study applied least absolute shrinkage and selection operator regression, random forest and support vector machine‑recursive feature elimination techniques to pinpoint signature genes driving psoriasis. Subsequently, CIBERSORT was used to determine whether psoriasis‑infiltrating immune cells had a strong connection with signature genes. Immunohistochemistry (IHC) was used to demonstrate the expression of TGM1 in human psoriasis samples. Cell transfection was employed to verify the function of TGM1. The top 163 significant DEGs were identified from the GSE30999 dataset, and Kyoto Encyclopedia of Genes and Genomes analysis illustrated that these genes were mostly involved in 'viral protein interaction with cytokine and cytokine receptor', as well as the 'IL‑17 signaling pathway'. The present study screened transglutaminase 1 (TGM1) as a signature gene by combining three machine learning algorithms. Through single‑gene GSEA, the present study further revealed that TGM1 was associated with 'GF‑RTK‑PI3K signaling pathway' and 'cytokine‑JAK‑STAT signaling pathway', providing valuable insights into the underlying mechanism of psoriasis. Additionally, the present study validated TGM1 expression in the GSE53552 and GSE13355 datasets, and demonstrated its elevated expression in lesional psoriatic skin using IHC. Finally, TGM1 overexpression was demonstrated to increase the expression levels of inflammatory factors and keratinocyte differentiation markers, whereas knockdown decreased their expression, especially IL‑1β, S100A8, S100A9 and K1. Together, these findings suggest that TGM1 could be a promising therapeutic target for psoriasis, highlighting its potential application in psoriasis therapy.<p><a href="http://europepmc.org/article/MED/41268597?source=rss" rel="external nofollow">Weiterlesen</a></p>]]></description><guid isPermaLink="false">342</guid><pubDate>Tue, 25 Nov 2025 19:50:44 +0000</pubDate></item></channel></rss>
