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Sci Rep. 2024 Oct 11;14(1):23848. doi: 10.1038/s41598-024-75069-x. ABSTRACT The epidermal infiltration of neutrophils is a hallmark of psoriasis (PSO) and its activation leads to the release of neutrophil extracellular traps (NETs). However, the molecular mechanism of NETs-related genes (NETRGs) has not been extensively studied in PSO. To define NETs-related-biomarkers for PSO. The GSE13355 and GSE78097 datasets, and NETRGs gene set were included in this study. The datasets used in this study we

Biomol Biomed. 2024 Apr 5. doi: 10.17305/bb.2024.10327. Online ahead of print. ABSTRACT Psoriasis is a globally prevalent chronic inflammatory skin disease. This study aimed to scrutinize the hub genes related to inflammation and potential molecular mechanisms in psoriasis. Utilizing mRNA expression profiles from public datasets GSE13355, GSE78097, and GSE14905, we set up a comprehensive analysis. Initially, we selected differentially expressed genes (DEGs) from psoriasis and control samples in

Lancet. 2024 Oct 26;404(10463):1679-1692. doi: 10.1016/S0140-6736(24)01750-1. ABSTRACT Biological monoclonal antibody drugs inhibit overactive cytokine signalling that drives chronic inflammatory disease in different organ systems. In the last 10 years, interleukin (IL)-23 inhibitors have attained an important position in the treatment of psoriatic skin and joint disease as well as inflammatory bowel diseases. Addressing an upstream pathological mechanism shared between these disorders, this dru

J Invest Dermatol. 2024 Oct 9:S0022-202X(24)02180-8. doi: 10.1016/j.jid.2024.08.039. Online ahead of print. ABSTRACT Imaging Mass Cytometry (IMC) is a technology that enables comprehensive analysis of cellular phenotypes at the tissue level. We performed a multi-parameter characterization of structural and immune cell populations in psoriatic skin and synovial tissue samples aimed at characterizing immune cell differences in patients with psoriasis, psoriatic arthritis (PsA). A panel of 33 antib

J Am Acad Dermatol. 2024 May 16:S0190-9622(24)00753-9. doi: 10.1016/j.jaad.2024.05.021. Online ahead of print. NO ABSTRACT PMID:38762009 | DOI:10.1016/j.jaad.2024.05.021 Den ganzen Artikel lesen

Cutis. 2024 Feb;113(2):75-80. doi: 10.12788/cutis.0942. ABSTRACT Diet plays an emerging role in dermatologic therapy. The ketogenic and low-glycemic diets have potential anti-inflammatory and metabolic effects, making them attractive for treating inflammatory skin conditions. We provide an overview of the current evidence on the effects of ketogenic and low-glycemic diets on inflammatory skin conditions including acne, psoriasis, seborrheic dermatitis (SD), atopic dermatitis (AD), and hidradenit

Arch Dermatol Res. 2025 Jan 18;317(1):286. doi: 10.1007/s00403-025-03818-7. ABSTRACT Atherosclerosis, in which chronic inflammation is also effective in it's pathogenesis, is an important cause of morbidity and mortality in psoriasis patients. Early diagnosis and management of atherosclerosis is important. Measurement of carotid intima media thickness is a method used to determine subclinical atherosclerosis. Our aim in this study is to evaluate subclinical atherosclerosis in psoriasis patients

J Clin Aesthet Dermatol. 2024 Oct;17(10):63-67. ABSTRACT OBJECTIVE: Tildrakizumab, an anti-interleukin-23 p19 monoclonal antibody, is approved for the treatment of adults with moderate-to-severe plaque psoriasis. Limited evidence is available regarding the effects of tildrakizumab on patient-reported symptoms and satisfaction. This report describes the secondary endpoints of patient-reported symptoms and treatment satisfaction over 64 weeks in patients with moderate-to-severe plaque psoriasis tr

Exp Dermatol. 2024 Oct;33(10):e70003. doi: 10.1111/exd.70003. ABSTRACT Psoriasis is a chronic autoimmune disease with a long disease course and frequent relapse characteristics. It is now recognised to be associated with epidermal environments of inflammatory cytokines. However, its pathogenesis is still not completely clear. We found the haemorheology of psoriatic patients to be abnormal, and ageing and deformed erythrocytes increased in the blood. The abnormal erythrocytes were more likely to

Expert Opin Drug Saf. 2024 Oct 4. doi: 10.1080/14740338.2024.2412221. Online ahead of print. ABSTRACT OBJECTIVE: The study aims to thoroughly assess the adverse events related to infections and infestations associated with biological agents used for psoriasis using the U.S. Food and Drug Administration's Adverse Event Reporting System (FAERS) database. METHODS: We analyzed FAERS data from the first quarter of 2004 to the fourth quarter of 2023. The study included TNF-α inhibitors (etanercept, in

Cureus. 2024 Sep 3;16(9):e68510. doi: 10.7759/cureus.68510. eCollection 2024 Sep. ABSTRACT Objective In this study, we aimed to investigate the correlation between the clinical diagnosis, histological diagnosis, and patch test positivity among patients with foot dermatoses receiving treatment at the Department of Dermatology, MES Medical College, Perinthalmanna. Methodology A hospital-based cross-sectional observational diagnostic evaluation was carried out from January 1, 2019, to December 31,

J Allergy Clin Immunol. 2024 May 16:S0091-6749(24)00506-2. doi: 10.1016/j.jaci.2024.05.008. Online ahead of print. ABSTRACT The routine use of targeted systemic immunomodulatory therapies has transformed outcomes for people with severe psoriasis, with skin clearance (clinical remission) rates up to 60% at one year of biologic treatment. However, psoriasis may recur following drug withdrawal, and so patients tend to remain on costly treatment indefinitely. Here, we review research into the 'infla

Cureus. 2024 Sep 22;16(9):e69912. doi: 10.7759/cureus.69912. eCollection 2024 Sep. ABSTRACT Background Psoriasis is a persistent inflammatory condition of the skin marked by clearly demarcated red plaques adorned with silvery scales. It impacts individuals across different age ranges and presents with unique clinical, histological, and dermoscopic characteristics. This research seeks to offer an extensive assessment of the demographic, clinical, histological, and dermoscopic attributes of chroni

Arch Dermatol Res. 2024 May 17;316(5):176. doi: 10.1007/s00403-024-02886-5. ABSTRACT Psoriasis is a chronic immune mediated inflammatory skin disease with systemic manifestations. It has been reported that caloric restriction could improve severity of psoriasis patients. However, the mechanism of intermittent fasting effects on psoriasis has not been investigated. Caloric restriction is known to reduce the number of circulating inflammatory monocytes in a CCL2-dependent manner. However, it is st

Clin Dermatol. 2024 Aug 31:S0738-081X(24)00150-0. doi: 10.1016/j.clindermatol.2024.08.010. Online ahead of print. ABSTRACT Dr. Benjamin Bender (1908-1996) was a longtime Clinical Professor of Dermatology at the State University of New York Downstate College of Medicine. Some 45 years ago, he coined the eponym Bender sign, which describes the discovery of cutaneous diseases that involve the gluteal cleft by having patients bend over and then manually separating the buttocks. Bender's eponym was c

J Ethnopharmacol. 2024 Oct 2:118882. doi: 10.1016/j.jep.2024.118882. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Sophocarpine is a bioactive compound extracted from the dried root of Sophorae Flavesentis Aiton, a plant that has been used for thousands of years for various conditions including skin itch and pain. Its antipruritic and analgesic effects are suggested in publications, while the molecular mechanisms underneath interacting with TRP channels are not understood. AIM

Int J Mol Sci. 2024 Apr 21;25(8):4545. doi: 10.3390/ijms25084545. ABSTRACT IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is member of the IQGAP family of scaffold proteins, which are essential for assembling multiprotein complexes that coordinate various intracellular signaling pathways. Previous research has shown that IQGAP3 is overexpressed in psoriatic skin lesions. Given its involvement in processes like cell proliferation and chemokine signaling, we sought to explore its molecul

Transl Androl Urol. 2024 May 31;13(5):748-758. doi: 10.21037/tau-24-10. Epub 2024 May 28. ABSTRACT BACKGROUND: The association between psoriasis and erectile dysfunction (ED) is currently inconsistent in epidemiological and observational studies and the causal relationship between them has not been established. The aim of our study is to explore the potential genetic association between ED and psoriasis. METHODS: We explored the putative causality between psoriasis and ED by bidirectional Mendel

Ital J Dermatol Venerol. 2024 May 10. doi: 10.23736/S2784-8671.24.07664-3. Online ahead of print. ABSTRACT SIDeMaST (Società Italiana di Dermatologia Medica, Chirurgica, Estetica e delle Malattie Sessualmente Trasmesse) contributed to the development of the present guideline on the systemic treatment of chronic plaque psoriasis. With the permission of EuroGuiDerm, SIDeMaST adapted the guideline to the Italian healthcare context to supply a reliable and affordable tool to Italian physicians who t

Ital J Dermatol Venerol. 2024 May 10. doi: 10.23736/S2784-8671.24.07666-7. Online ahead of print. ABSTRACT SIDeMaST (Società Italiana di Dermatologia Medica, Chirurgica, Estetica e delle Malattie Sessualmente Trasmesse) contributed to the development of the present guideline on the systemic treatment of chronic plaque psoriasis. With the permission of EuroGuiDerm, SIDeMaST adapted the guideline to the Italian healthcare context to supply a reliable and affordable tool to Italian physicians who t

Br J Dermatol. 2024 Oct 12:ljae391. doi: 10.1093/bjd/ljae391. Online ahead of print. ABSTRACT BACKGROUND: Air pollution and genetic risk have been found to contribute to both onset and development of psoriasis. However, the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of incident psoriasis remains unknown. OBJECTIVES: Our study aimed to assess the association between joint exposure to multiple air pollutants and the risk of psoriasis and the modificat

Ital J Dermatol Venerol. 2024 Dec;159(6):684-685. doi: 10.23736/S2784-8671.24.08051-4. NO ABSTRACT PMID:39898382 | DOI:10.23736/S2784-8671.24.08051-4 Den ganzen Artikel lesen

Dermatol Ther (Heidelb). 2025 Mar 6. doi: 10.1007/s13555-025-01370-w. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin disease affecting over 60 million people worldwide, often linked to comorbidities such as psoriatic arthritis and cardiovascular disease. Beyond physical symptoms, psoriasis can significantly impact major life-changing decisions (MLCDs), leading to long-term consequences and missed opportunities. This study focused on assessing MLCDs and the

Pharmaceutics. 2024 Sep 30;16(10):1287. doi: 10.3390/pharmaceutics16101287. ABSTRACT BACKGROUND: Baricitinib, commonly used for autoimmune diseases, is typically administered orally, which can lead to systemic adverse effects. A topical formulation could potentially offer localized therapeutic effects while minimizing these side effects. OBJECTIVES: This study focuses on developing a lipid-based topical formulation of baricitinib (BCT-OS) for treating psoriasis. METHODS: The optimized formulatio

Int J Rheum Dis. 2024 Oct;27(10):e15390. doi: 10.1111/1756-185X.15390. ABSTRACT OBJECTIVES: To evaluate the risk of liver fibrosis and associated factors with the non-invasive fibrosis score-4 (FIB-4) index in patients with inflammatory arthritis using methotrexate (MTX). METHODS: Patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) who were followed up in the rheumatology outpatient clinic, who were on methotrexate only and for whom FIB-4 index was could be calculated at methot