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Int Immunopharmacol. 2024 May 17;134:112261. doi: 10.1016/j.intimp.2024.112261. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis, a chronic inflammatory condition of the skin, is characterized by an atypical proliferation of epidermal keratinocytes and immune cell infiltration. Orientin is a flavonoid monomer with potent anti-inflammatory activities. However, the therapeutic effects of orientin on psoriasis and the underlying mechanisms have not been elucidated. OBJECTIVE: To investigate th

J Am Acad Dermatol. 2025 Jan 3:S0190-9622(25)00007-6. doi: 10.1016/j.jaad.2024.12.035. Online ahead of print. NO ABSTRACT PMID:39756616 | DOI:10.1016/j.jaad.2024.12.035 Den ganzen Artikel lesen

Cancer Sci. 2024 Oct 22. doi: 10.1111/cas.16378. Online ahead of print. ABSTRACT Our previous research has demonstrated that P2RY6 functions as an oncogene in DMBA/TPA-induced two-stage chemical skin carcinogenesis in mice. However, considering that human skin cancer is predominantly attributed to UV radiation from sunlight, additional investigations are needed to elucidate the role of P2RY6 in UVB-induced skin carcinogenesis. Surprisingly, we found that P2ry6-deficient mice exhibited marked pro

SAGE Open Med Case Rep. 2025 Jan 31;13:2050313X251317763. doi: 10.1177/2050313X251317763. eCollection 2025. ABSTRACT Palmoplantar plaque psoriasis is more resistant to therapy compared to other phenotypes of psoriasis. To our knowledge, there are no reports of the efficacy of Janus kinase (JAK) inhibitors for palmoplantar plaque psoriasis. Two adult females presented with more than 6-year histories of severe palmoplantar plaque psoriasis. The first patient had failed topical therapies, photother

Skin Res Technol. 2024 May;30(5):e13718. doi: 10.1111/srt.13718. ABSTRACT INTRODUCTION: Due to the increasing prevalence of immune-mediated diseases such as psoriasis, lichen planus, rheumatoid arthritis and inflammatory bowel disease, dermatologists have turned to new biologic drugs known as DMARDs (disease-modifying anti-rheumatic drugs) in recent years. AREAS COVERED: In this study, we evaluate the immune-mediated dermatological side effects of DMARDS by reviewing and analyzing previous peer-

Indian J Dermatol. 2025 Jan-Feb;70(1):42-46. doi: 10.4103/ijd.ijd_719_24. Epub 2024 Dec 30. ABSTRACT Behçet's disease is a chronic inflammatory condition that affects multiple organs and systems. It is characterized by recurrent oral and genital ulcers. A previous study reported that the IL-17A inhibitor secukinumab can improve the skin and mucosal manifestations in patients with refractory Behçet's disease. Additionally, secukinumab has been shown to effectively improve neurological symptoms wh

Cureus. 2024 May 10;16(5):e60051. doi: 10.7759/cureus.60051. eCollection 2024 May. ABSTRACT Psoriasis is a chronic dermatologic condition that oftentimes requires extensive trial and error with various topical and systemic therapies until improvement is achieved. Interleukin-17 inhibitors (IL-17i), such as secukinumab, have been utilized in the treatment of psoriasis due to their mechanism of action. As with all medications, IL-17 inhibitors possess adverse effects, the most common being infecti

Cureus. 2025 Jan 13;17(1):e77363. doi: 10.7759/cureus.77363. eCollection 2025 Jan. ABSTRACT Paradoxical reactions (PRs) to biologic medications, such as psoriasis, arthritis, and inflammatory bowel disease (IBD), have been increasingly recognized. The aim of reporting this case is to establish an association between golimumab and exacerbation or new (de novo) IBD in patients with axial spondyloarthritis (SpA). Our case involves a young patient with juvenile-onset ankylosing spondylitis (AS) who

Indian J Dermatol Venereol Leprol. 2024 Apr 2:1-9. doi: 10.25259/IJDVL_719_2023. Online ahead of print. ABSTRACT Background The paradoxical occurrence of psoriasis triggered by Interleukin-17 (IL-17) inhibitors is notable due to its prominent symptoms and the therapeutic dilemma it presents for follow-up care. Objective To describe cases in our clinic, perform an in-depth literature review, and suggest the most probable mechanisms of action. Method We conducted a literature review on published c

J Invest Dermatol. 2024 Jul 2:S0022-202X(24)01731-7. doi: 10.1016/j.jid.2024.05.015. Online ahead of print. ABSTRACT The definition of paradoxical psoriasis (PP) encompasses 2 main scenarios, namely, (i) new-onset psoriasis in patients treated for a different disease and (ii) worsening as well as phenotypical change of pre-existing psoriasis. Originally restricted to the appearance of an untoward psoriasiform reaction under TNF inhibitors, the term has gained new meaning, with the progressive ob

ACR Open Rheumatol. 2024 Oct 4. doi: 10.1002/acr2.11732. Online ahead of print. ABSTRACT OBJECTIVE: Group-level analyses from the phase 3 DISCOVER-2 trial of guselkumab demonstrated robust and durable improvements across psoriatic arthritis (PsA) domains. To specifically evaluate continuous disease control in individual patients, persistence of clinically relevant improvements was assessed, both at consecutive guselkumab dosing visits and over time. METHODS: Post hoc analyses included biologic-n

J Clin Aesthet Dermatol. 2024 Dec;17(11):32-33. ABSTRACT We present a case of a patient with longstanding psoriasis vulgaris who developed an atopic dermatitis-like eruption following long-term IL-17A inhibitor therapy. Following many years of excellent disease control with secukinumab and later ixekizumab, he developed a de novo eczematous eruption, which showed spongiotic dermatitis upon biopsy. The patient was successfully treated for both psoriasis and atopic dermatitis with upadacitinib, a

Curr Nutr Rep. 2025 Mar 6;14(1):42. doi: 10.1007/s13668-025-00632-5. ABSTRACT PURPOSE OF REVIEW: In this narrative review, we provide an overview of how adherence to a Mediterranean dietary pattern can complement traditional treatment strategies for psoriasis, acne, and hidradenitis suppurativa. We emphasize the importance of an integrated approach, with dietary interventions as a key component of holistic patient care. RECENT FINDINGS: Psoriasis, acne, and hidradenitis suppurativa are immune-me

Int J Mol Sci. 2024 Mar 23;25(7):3617. doi: 10.3390/ijms25073617. ABSTRACT Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin

Arch Dermatol Res. 2025 Jan 13;317(1):237. doi: 10.1007/s00403-024-03701-x. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin disorder affecting millions worldwide. Dermoscopy and proximal nailfold capillaroscopy have emerged as valuable tools for understanding the pathophysiology and treatment response of psoriasis lesions. OBJECTIVES: This study aimed to contribute to the limited literature on using dermoscopic findings to detect treatment effectiveness in patients with psoriasis

Pharmaceutics. 2024 Oct 14;16(10):1329. doi: 10.3390/pharmaceutics16101329. ABSTRACT BACKGROUND: The treatment of psoriasis has made considerable progress with biologicals, including tumor necrosis factor inhibitors, and recently, monoclonal antibodies inhibiting directly interleukin (IL) 17, IL-23, or both IL-12/23. Newer biologicals are directed to the interleukin pathway and appear to improve complete or near-complete clearance. The newer biologicals have also been shown to have an excellent

Medicine (Baltimore). 2024 May 3;103(18):e38007. doi: 10.1097/MD.0000000000038007. ABSTRACT BACKGROUND: This systematic review and meta-analysis aimed to report the evaluation of the prevalence and risk of nonalcoholic fatty liver disease (NAFLD) among adult psoriatic patients in a systematic review and meta-analysis. METHODS: A comprehensive search was conducted across 4 databases of PubMed, Scopus, Cochrane Library, and Web of Science to collect relevant studies until November 30, 2023, withou

Cureus. 2024 Aug 28;16(8):e68037. doi: 10.7759/cureus.68037. eCollection 2024 Aug. ABSTRACT Introduction Psoriasis is a chronic, recurrent inflammatory skin condition that affects 1-3% of the global population. Increasing evidence suggests a higher prevalence of metabolic syndrome (MetS) among individuals with psoriasis. This study aims to investigate the prevalence of MetS in patients with psoriasis and compare the findings with existing literature. Methods This cross-sectional, hospital-based

Dermatol Reports. 2023 Aug 29;16(2):9778. doi: 10.4081/dr.2023.9778. eCollection 2024 Jun 14. ABSTRACT Few studies have examined pruritus in elderly patients, a common dermatological condition. The study examines pruritus prevalence and characteristics in elderly patients referred to the Dermatology Unit, at Genoa's Galliera Hospital. The demographic characteristics of all Outpatient Clinic patients with any skin condition were examined, focusing on pruritus patients over 65. Pruritus was presen

Dermatol Reports. 2025 Mar 5. doi: 10.4081/dr.2025.10239. Online ahead of print. ABSTRACT Infantile hemangiomas are the most common soft-tissue tumors in children, with propranolol, a non-cardioselective β-blocker, considered the first-line treatment for complicated cases. β-blockers have been reported to be the most common causative agents for drug-induced psoriasis in adults. In the pediatric population, only one previous case exists. We report the case of a 12-month-old girl who developed a p

Dermatol Ther (Heidelb). 2024 Apr 9. doi: 10.1007/s13555-024-01152-w. Online ahead of print. ABSTRACT Psoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and psychiatric disorders, chronic inflammatory bowel disease, psoriatic arthritis, etc. Regarding cardiovascular comorbidities, major adverse cardiovascular events have been reported in psoriasis patients by multiple epidemiologic studies. Moreover, smoking,

Arch Dermatol Res. 2025 Jan 16;317(1):256. doi: 10.1007/s00403-025-03810-1. NO ABSTRACT PMID:39820719 | DOI:10.1007/s00403-025-03810-1 Den ganzen Artikel lesen

JAAD Int. 2024 May 9;16:119-121. doi: 10.1016/j.jdin.2024.03.018. eCollection 2024 Sep. NO ABSTRACT PMID:38957840 | PMC:PMC11217681 | DOI:10.1016/j.jdin.2024.03.018 Den ganzen Artikel lesen

J Insur Med. 2025 Jul 1;52(1):3-5. doi: 10.17849/insm-52-1-3-5.1. ABSTRACT OBJECTIVE.—: To analyze a published study on all-cause mortality between psoriatic arthritis and matched population comparator-subjects to derive comparative mortality statistics applicable to life insurance underwriting. METHOD.—: The pixel method was employed for extracting cumulative survivals. It was chosen for its capability to extract data from published graphs despite potential precision and reliability limitations

Arch Dermatol Res. 2025 Jan 17;317(1):269. doi: 10.1007/s00403-025-03808-9. ABSTRACT Psoriasis is associated with psychological distress among the affected due to unsightly skin lesions, chronicity and the cultural and social stigma linked with the disease. The pathophysiological link between psoriasis and depression creates a vicious cycle in the skin and brain axis. This study evaluates the psychological comorbidity of patients with chronic plaque psoriasis (CPP). A cross-sectional study was c