Aus Pubmed

Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May. ABSTRACT Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in th

Cureus. 2024 Mar 8;16(3):e55773. doi: 10.7759/cureus.55773. eCollection 2024 Mar. ABSTRACT Psoriasis is a chronic autoimmune inflammatory skin disease that is associated with other conditions, one of them being psoriatic arthritis (PsA). Apremilast, a phosphodiesterase-4 inhibitor, displayed promising results in multiple trials for patients with PsA. This systematic review and meta-analysis aims to showcase its efficacy and safety when compared to placebo. Preferred Reporting Items for Systemati

J Eur Acad Dermatol Venereol. 2024 Apr 9. doi: 10.1111/jdv.20004. Online ahead of print. NO ABSTRACT PMID:38590284 | DOI:10.1111/jdv.20004 Den ganzen Artikel lesen

Bioorg Chem. 2024 Apr 6;147:107351. doi: 10.1016/j.bioorg.2024.107351. Online ahead of print. ABSTRACT Eleven triterpenoid saponins, including five new compounds, which were named densiflorasides A - E (1 - 5), were isolated from aerial parts of Mussaenda densiflora (Rubiaceae). Their structures were elucidated based on spectroscopic and single-crystal X-ray diffraction analyses and chemical methods. All the isolated compounds and the aglycone heinsiagenin A were evaluated for their immunosuppre

J Dtsch Dermatol Ges. 2024 Apr 9. doi: 10.1111/ddg.15364. Online ahead of print. NO ABSTRACT PMID:38593343 | DOI:10.1111/ddg.15364 Den ganzen Artikel lesen

Macromol Rapid Commun. 2024 Apr 9:e2400136. doi: 10.1002/marc.202400136. Online ahead of print. ABSTRACT In the work, we designed a natural medicine baicalin for the treatment of psoriasis with the aid of hyaluronic acid (HA)-based MNs patches. In order to improve the solubility of baicalin and increase its residence time in infected part, which was made into nanoparticles by complexation with humic acid and Eu2+. The baicalin nanoparticles loaded-MNs exhibited satisfactory rigidity, minimum inj

Cutis. 2024 Feb;113(2):82-91. doi: 10.12788/cutis.0949. ABSTRACT Psoriasis is a chronic heterogeneous condition with multiple available treatment options that have resulted in dramatic disease improvements for patients. IL-23/IL-17 signaling is the central immune signaling pathway driving psoriasis, though recent research has uncovered other key contributing signals such as IL-17C, IL-17F, IL-36, and tyrosine kinase 2 (TYK2). Novel therapeutic targets inhibiting these cytokines have expanded our

Cutis. 2024 Feb;113(2):68-96. doi: 10.12788/cutis.0946. NO ABSTRACT PMID:38593099 | DOI:10.12788/cutis.0946 Den ganzen Artikel lesen

Cutis. 2024 Feb;113(2):54-55. doi: 10.12788/cutis.0950. NO ABSTRACT PMID:38593093 | DOI:10.12788/cutis.0950 Den ganzen Artikel lesen

Cutis. 2024 Feb;113(2):75-80. doi: 10.12788/cutis.0942. ABSTRACT Diet plays an emerging role in dermatologic therapy. The ketogenic and low-glycemic diets have potential anti-inflammatory and metabolic effects, making them attractive for treating inflammatory skin conditions. We provide an overview of the current evidence on the effects of ketogenic and low-glycemic diets on inflammatory skin conditions including acne, psoriasis, seborrheic dermatitis (SD), atopic dermatitis (AD), and hidradenit

Dermatol Ther (Heidelb). 2024 Apr 9. doi: 10.1007/s13555-024-01152-w. Online ahead of print. ABSTRACT Psoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and psychiatric disorders, chronic inflammatory bowel disease, psoriatic arthritis, etc. Regarding cardiovascular comorbidities, major adverse cardiovascular events have been reported in psoriasis patients by multiple epidemiologic studies. Moreover, smoking,

Front Med Technol. 2024 Mar 25;6:1200400. doi: 10.3389/fmedt.2024.1200400. eCollection 2024. ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory follicular skin condition that is associated with significant psychosocial and economic burden and a diminished quality of life and work productivity. Accurate diagnosis of HS is challenging due to its unknown etiology, which can lead to underdiagnosis or misdiagnosis that results in increased patient and healthcare system burden. We applie

J Immunol Res. 2024 Apr 1;2024:9927964. doi: 10.1155/2024/9927964. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite this known association, the cellular and molecular mechanisms underlying this progression remain unclear. METHODS: We performed high-dimensional, in-depth

Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May. ABSTRACT Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in th

Cureus. 2024 Mar 8;16(3):e55773. doi: 10.7759/cureus.55773. eCollection 2024 Mar. ABSTRACT Psoriasis is a chronic autoimmune inflammatory skin disease that is associated with other conditions, one of them being psoriatic arthritis (PsA). Apremilast, a phosphodiesterase-4 inhibitor, displayed promising results in multiple trials for patients with PsA. This systematic review and meta-analysis aims to showcase its efficacy and safety when compared to placebo. Preferred Reporting Items for Systemati

J Eur Acad Dermatol Venereol. 2024 Apr 9. doi: 10.1111/jdv.20004. Online ahead of print. NO ABSTRACT PMID:38590284 | DOI:10.1111/jdv.20004 Den ganzen Artikel lesen

J Am Acad Dermatol. 2024 Apr 6:S0190-9622(24)00568-1. doi: 10.1016/j.jaad.2024.03.041. Online ahead of print. ABSTRACT BACKGROUND: Patients with psoriasis are at increased risk of liver function abnormalities. OBJECTIVE: Explore rates of hepatic treatment-emergent adverse events (TEAEs) and changes in liver parameters in bimekizumab-treated patients with psoriasis. METHODS: Data are reported from five phase 3/3b trials over 2 years. Hepatic TEAEs, laboratory elevations in alanine aminotransferas

Dermatology. 2024 Apr 8. doi: 10.1159/000536366. Online ahead of print. ABSTRACT BACKGROUND: Autosomal recessive congenital ichthyoses (ARCI) are a clinically heterogeneous group of keratinization disorders characterized by generalized skin scaling due to mutations in at least 12 genes. The aim of our study was to assess disease severity, phenotypic and ultrastructural features and to evaluate their association with genetic findings in ARCI patients. METHODS: Clinical signs and symptoms, and dis

J Am Acad Dermatol. 2024 Apr 6:S0190-9622(24)00568-1. doi: 10.1016/j.jaad.2024.03.041. Online ahead of print. ABSTRACT BACKGROUND: Patients with psoriasis are at increased risk of liver function abnormalities. OBJECTIVE: Explore rates of hepatic treatment-emergent adverse events (TEAEs) and changes in liver parameters in bimekizumab-treated patients with psoriasis. METHODS: Data are reported from five phase 3/3b trials over 2 years. Hepatic TEAEs, laboratory elevations in alanine aminotransferas

Dermatology. 2024 Apr 8. doi: 10.1159/000536366. Online ahead of print. ABSTRACT BACKGROUND: Autosomal recessive congenital ichthyoses (ARCI) are a clinically heterogeneous group of keratinization disorders characterized by generalized skin scaling due to mutations in at least 12 genes. The aim of our study was to assess disease severity, phenotypic and ultrastructural features and to evaluate their association with genetic findings in ARCI patients. METHODS: Clinical signs and symptoms, and dis