Vaccination is a fundamental principle of preventive health care. Administration of the vaccine, which contains the antigen(s) of a pathogen, activates the immune system and provides protection against infection. The immunogenicity and allergenicity of a vaccine may lead to various adverse reactions, depending on the responsiveness and susceptibility of the vaccinated individual. Cutaneous adverse events are among the most common and can manifest as various local or generalized vaccination reactions. Understanding their pathogenesis and clinical manifestations is essential for therapy, for further diagnostic clarification if necessary, and for managing any booster vaccination that may be required. Appropriate dermatological expertise therefore plays a crucial role in managing patients with a history of vaccination reactions.
