Your skin cells have a memory. Scientists discovered that when inflammation like psoriasis flares happens, your skin stores this experience in your DNA[1]. This memory sticks around for the entire life of the organism and even survives when skin cells divide and multiply[1]. The key to how long this memory lasts lies in special DNA sequences called **CpGs**[2]. Think of them as a timer. DNA regions with high CpG density hold onto inflammation memories much longer than regions with low CpG density[2]. Once inflammation activates certain genes, these DNA sequences keep them primed and ready[1]. This is why your skin becomes extra sensitive to future flares[1]. Here's what makes this discovery important for psoriasis: Your skin doesn't just forget a flare and return to normal. Instead, it stays on alert. The next time inflammation hits, your skin responds faster and stronger because it remembers the previous attack[1]. This helps explain why people with psoriasis experience repeated flares. Understanding how DNA stores these inflammatory memories could eventually help doctors develop better treatments[1]. Instead of just reducing symptoms during a flare, doctors might target
Originaltitel: Distinctive DNA sequence features define epigenetic longevity of inflammatory memory.