The user is asking me to act as an editor for a news portal about psoriasis and psoriasis arthritis. They want me to summarize information about the immunological antagonism between psoriasis and atopic dermatitis in a way that a 10th grader can understand.
Key instructions for this response:
1. Write in a relaxed but correct style
2. Make it understandable for a 10th grader
3. Avoid complex sentences - max one comma per sentence
4. Avoid nominalizations (Substantivierungen)
5. Create paragraphs when a thought is complete
6. Maximum 1000 characters
Let me analyze the search results:
- Both psoriasis and atopic dermatitis are immune-mediated inflammatory skin diseases
- Traditionally considered distinct because they have different immune mechanisms
- Psoriasis is driven by Th17/Th1 cells and IL-17, IL-23
- Atopic dermatitis is driven by Th2 cells and IL-4, IL-13
- But there's overlap - some AD cases show IL-17 involvement, some psoriasis cases show Th2 involvement
- They can even coexist in the same person
- The traditional view of complete opposition is changing
I need to write this in German (based on the special instructions which are in German).
Let me structure this:
1. Brief intro about what these diseases are
2. The traditional view (they're opposite)
3. New findings (they overlap/aren't so opposite)
4. Implications
I need to keep it under 1000 characters, write simply, use short sentences, avoid complex structures.
Let me write in German as instructed:
Psoriasis und Neurodermitis gelten lange Zeit als gegensätzliche Hauterkrankungen. Bei Psoriasis aktiviert sich das Immunsystem auf besondere Weise. Bei Neurodermitis funktioniert es anders. Deshalb dachten Ärzte lange, diese Krankheiten könnten sich "abstoßen".
Aktuelle Studien widerlegen dieses Bild. Patienten mit Neurodermitis entwickeln manchmal auch Psoriasis-Symptome. Umgekehrt zeigen manche Psoriasis-Patienten Neurodermitis-Zeichen. Einige Menschen haben sogar beide Erkrankungen gleichzeitig. Die Grenzen verschwimmen also. Das bedeutet auch, dass eine Behandlung möglicherweise bei beiden hilft. I'm checking my language choices against the guidelines. Some words like "Reaktionen" and "Entzündungswege" are nouns derived from verbs, but they seem necessary here. Let me focus on replacing the most avoidable nominalizations by using active verbs instead.
I'll restructure to use more direct verb forms. Rather than "Reaktionen," I can say how the immune system actually responds. Instead of describing "Entzündungswege," I can describe what happens when inflammation occurs. This makes the sentences more dynamic while keeping the meaning intact.
For the continuation: Manche Patienten haben sogar beide Krankheiten gleichzeitig. Die Unterschiede sind also nicht so klar wie gedacht. Beide Krankheiten nutzen ähnliche Entzündungswege. Das ändert, wie Ärzte behandeln. Eine Therapie könnte bei beiden wirken. Ich sollte überprüfen, ob die Quellenangaben korrekt eingebunden sind. Die Anleitung verlangt, dass ich Informationen zusammenfasse und dabei im
Originaltitel: Immunological antagonism between psoriasis and atopic dermatitis: Path | CCID
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