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**Hauterkrankungen und Psyche: Was Psoriasis und Vitiligo verbindet** Menschen mit Hauterkrankungen kämpfen oft mit mehr als nur den sichtbaren Symptomen. Eine neue deutsche Studie zeigt jetzt, wie häufig psychische Probleme bei verschiedenen Hautkrankheiten auftreten[1]. Forscher haben Daten von fast 3 Millionen Versicherten analysiert. Sie verglichen Menschen mit Vitiligo mit Psoriasis-Patienten und anderen Gruppen[1]. Das Ergebnis ist wichtig für Sie: Menschen mit Vitiligo haben deutlich mehr Angststörungen und Depressionen als Psoriasis-Patienten. Bei Vitiligo treten diese psychischen Probleme etwa 2 bis 3 Mal häufiger auf[1]. Aber auch bei Psoriasis ist die psychische Belastung hoch. Weltweit berichten über 58 Prozent der Patienten von Depressionen oder Angst[2]. Viele vermeiden soziale Kontakte oder fühlen sich weniger selbstbewusst[2]. Die gute Nachricht: Experten fordern jetzt bessere psychologische Unterstützung für alle Patienten mit sichtbaren Hauterkrankungen. Das bedeutet, dass Ärzte künftig nicht nur die Haut, sondern auch die Psyche behandeln sollten[1][2]. Wenn Sie mit Psoriasis kämpfen und sich niedergeschlagen fühlen, sprechen Sie mit Ihrem Arzt. Psychologische Hilfe ist genauso wichtig wie Hautbehandlungen. Originaltitel: Prevalence and comparative risk of mental health disorders in persons with vitiligo: a retrospective matched cohort study using claims data with expert-informed case validation. Link zur Quelle

# Wenn die Haut leidet, leidet auch die Seele Menschen mit Schuppenflechte, Neurodermitis oder Hidradenitis suppurativa brauchen nicht nur eine gute Hautbehandlung. Sie benötigen auch psychologische Unterstützung. Das zeigt jetzt eine große internationale Studie mit insgesamt über eine Million Patienten.[1] Die Forschung hat ergeben: Patienten mit diesen Hauterkrankungen suchen deutlich häufiger psychologische Hilfe auf als gesunde Menschen. Bei Neurodermitis ist der Anstieg besonders groß. Diese Patienten gehen etwa dreimal häufiger zur Psychotherapie als Kontrollpersonen ohne Hauterkrankung.[1] **Aber warum ist das so?** Die chronischen Hautleiden verändern die Lebensqualität stark. Sichtbare Flecken und Ausschläge belasten viele Menschen emotional. Manche entwickeln Depressionen oder Angststörungen.[3] Zudem beeinflussen die Entzündungsprozesse in der Haut auch das Nervensystem und können Stimmung und Psyche belasten.[3] Interessant: Männer und Frauen sind unterschiedlich betroffen. Bei Neurodermitis leiden Frauen stärker unter psychischen Belastungen. Bei Schuppenflechte ist es etwas ausgewogener verteilt.[1] **Das Fazit der Studie:** Ärzte sollten Haut- und Seelenpflege gemeinsam angehen. Wer regelmäßig zur Hauttherapeut geht, sollte auch ein offenes Ohr für psychische Belastungen haben. Psychologische Hilfe gehört zur modernen Behandlung einfach dazu. Originaltitel: Psychiatric and Psychological Approach in Patients with Atopic Dermatitis, Hidradenitis Suppurativa and Psoriasis: A Propensity-Matched Real-World Cohort Study. Link zur Quelle

Originaltitel: Psychiatric and Psychological Approach in Patients with Atopic Dermatitis, Hidradenitis Suppurativa and Psoriasis: A Propensity-Matched Real-World Cohort Study - Dermatology and Therapy Link zur Quelle

Originaltitel: Editorial: Advancements in AI for the analysis and interpretation of large-scale data by omics techniques. Link zur Quelle

Originaltitel: Joint Assessment Matters: Diagnostic and Therapeutic Benefits of Interdisciplinary Psoriasis Care - Advances in Therapy Link zur Quelle

Originaltitel: Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch Link zur Quelle

# Magnesium: Das Wundermittel für deine Haut? Magnesium könnte für Menschen mit Psoriasis interessant sein. Der Mineralstoff hilft deinem Körper bei über 300 verschiedenen Prozessen.[1] Besonders wichtig: Er wirkt entzündungshemmend.[1][2] Das ist gute Nachricht für dich. Denn Psoriasis entsteht durch Entzündungen in der Haut.[1] Magnesium kann diese Entzündungen beruhigen und Rötungen reduzieren.[1] Stress verschlimmert Psoriasis oft. Hier hilft Magnesium gleich doppelt. Es senkt den Stresshormon Cortisol in deinem Körper.[4] Gleichzeitig verbessert es deine Schlafqualität.[1] Besserer Schlaf bedeutet weniger Stress für deine Haut. Auch die Hautbarriere profitiert. Magnesium unterstützt die natürliche Feuchtigkeitsversorgung deiner Haut.[1][2] Das ist wichtig, weil Psoriasis die Haut austrocknet. Du kannst Magnesium auf zwei Wegen nutzen. Entweder nimmst du es als Nahrungsergänzung. Oder du verwendest Cremes und Öle mit Magnesium.[1][4] Studien zeigen: Magnesiumreiche Bäder (wie mit Totes-Meer-Salz) verbessern die Hautstruktur deutlich.[4] Sprich mit deinem Arzt, bevor du Magnesium nimmst. So findest ihr gemeinsam die beste Form für dich. Originaltitel: The role of magnesium in dermatology Link zur Quelle

Originaltitel: Joint Assessment Matters: Diagnostic and Therapeutic Benefits of Interdisciplinary Psoriasis Care. Link zur Quelle

BackgroundSkin is the largest organ of the human body. It continuously encounters environmental toxicants, including airborne pollutants, which may induce many skin disorders, such as psoriasis. However, evidence on the association between airborne pollutants and psoriasis prevalence in China remains limited.MethodsWe used nationwide inpatient diagnostic data on psoriasis from 2021 to 2023, encompassing 149 744 cases across 31 provinces, municipalities, and autonomous regions in China, along with corresponding air pollution data. We analysed the spatial distribution and clustering patterns of psoriasis using the spatial autocorrelation analysis. We employed Pearson correlation analysis and Geodetector to explore the spatial heterogeneity of psoriasis and its association with airborne pollutants at the provincial level. We assessed the explanatory power of individual airborne pollutants and their combined effects on psoriasis prevalence.ResultsPearson correlation analysis revealed that PM10 (r = 0.604), PM2.5 (r = 0.429), air quality index (AQI) (r = 0.542), and NO2 (r = 0.476) have significant positive correlations with psoriasis prevalence. Psoriasis and its subtypes exhibited significant spatial heterogeneity and diverse clustering patterns across regions. Geodetector identified PM10 (q = 0.357; P = 0.000), AQI (q = 0.315; P = 0.000), and O3 (q = 0.264; P = 0.000) as key contributors to this spatial heterogeneity. Interactive detection analysis further revealed that the combined effects of specific pollutant pairs, including PM2.5 and SO2 (q = 0.790), PM10 and SO2 (q = 0.727), as well as O3 and SO2 (q = 0.704), played a pivotal role in explaining the prevalence of psoriasis. The other combinations also showed an important impact on psoriasis subtypes, including psoriasis vulgaris (PM2.5 and SO2) (q = 0.792), psoriasis erythematous (PM2.5 and SO2) (q = 0.852), psoriatic arthritis (PM10 and O3) (q = 0.840), and nail psoriasis (PM10 and O3) (q = 0.789).ConclusionsThe airborne pollutants influence psoriasis prevalence and its subtypes. With the largest global study of the Asian population, we provide novel insights into the impact of air pollution on psoriasis, guiding future public health policies and clinical interventions.Weiterlesen

No abstract supplied.Weiterlesen

No abstract supplied.Weiterlesen

IntroductionBiologic therapies have transformed the management of moderate-to-severe psoriasis but are associated with long-term treatment burden and substantial healthcare costs. Dose spacing, defined as extending dosing intervals in patients with controlled disease, has emerged as a potential optimization strategy. However, data on real-world implementation and clinician perspectives remain limited.MethodsWe conducted a national, cross-sectional survey among Portuguese dermatologists experienced in prescribing biologic therapies for psoriasis. An anonymous, web-based questionnaire assessed clinicians' perspectives and real-world practices regarding biologic dose spacing, including eligibility criteria, preferred biologic classes, implementation strategies, outcomes after loss of disease control, and limiting clinical factors.ResultsSeventy-five dermatologists completed the survey (response rate 48.4%). All respondents considered dose spacing feasible. The most frequently cited eligibility criteria were absolute Psoriasis Area and Severity Index (PASI) ≤ 1, body surface area (BSA) ≤ 1%, and a 90% improvement in PASI (PASI 90). Interleukin-23 (IL-23) inhibitors were perceived as the most suitable class for dose spacing (93.3%). In routine practice, dose spacing was applied frequently by 30.7% of respondents and occasionally by 48.0%. Most clinicians (69.3%) required more than 12 months of sustained disease control before initiating dose spacing, predominantly using progressive extension of dosing intervals (96.0%). IL-23 inhibitors were the biologics most frequently dose-spaced in current practice. Following loss of disease control, 86.7% reported successful recapture of response after reintroduction of standard dosing. The main factors limiting dose spacing were a history of difficult-to-control psoriasis (77.3%) and concomitant psoriatic arthritis (72.0%).ConclusionBiologic dose spacing is already integrated into clinical practice in Portugal. Further prospective studies are needed to establish standardized criteria and guide safe implementation.Weiterlesen

This cross-sectional study aimed to determine the detectability of a panel of 92 inflammatory biomarkers in tape strips from the skin of patients with inflammatory skin diseases, and whether this depended on the number of tape strips taken. Furthermore, the biomarker levels in the patients were compared with those in healthy controls. Eight consecutive uniform tape strips (each 3.8 cm²) were obtained from 2 adjacent skin sites from 8 atopic dermatitis, contact dermatitis, and psoriasis patients, respectively, and 5 controls. Three separate analyses were carried out using the Olink® Target Inflammation panel: (i) all 8 tape strips (1-8) from 1 skin site and from the other skin site, (ii) the first 4 tape strips (1-4), and (iii) the next 4 tape strips (5-8). Biomarkers were above the detection limit for 65.7% of atopic dermatitis, 70.2% of psoriasis, and 45.1% of contact dermatitis samples. There were no significant differences in biomarker levels between the use of 4 or 8 tape strips, or between the first and last 4 tape strips. In general, atopic dermatitis and psoriasis patients were distinguishable from controls, whereas contact dermatitis patients were not. Based on the overall data quality, analysing protein signatures in tape strips with the targeted inflammatory panel is feasible.Weiterlesen

Photosensitive presentations of psoriasis are often under-recognized and may closely mimic other photodistributed dermatoses. We report the case of a 39-year-old male patient with no history of other photodermatoses who developed a progressive, non-pruritic rash, localized in sun-exposed skin areas, with marked exacerbation after phototherapy. Pronounced photosensitivity and atypical lesion distribution, involving the malar and nasal regions, complicated the initial differential diagnosis between photosensitive plaque psoriasis and cutaneous lupus erythematosus (CLE). Only further clinical evaluation, alongside histopathological analysis and immunological testing, helped to confirm the final diagnosis of photosensitive plaque psoriasis. Treatment with systemic and topical corticosteroids, vitamin D analogues, and calcineurin inhibitors resulted in gradual clinical improvement. This case report highlights photosensitive psoriasis as an important cause of photodistributed eruptions and a rare but significant mimic of CLE.Weiterlesen

ObjectiveTo evaluate the long-term efficacy of interleukin (IL)-17A inhibition with secukinumab on structural bone changes and clinical outcomes in psoriatic arthritis (PsA).MethodsWe conducted a phase-IV non-interventional study on adult patients with active PsA using high-resolution peripheral quantitative CT (HR-pQCT) and MRI of the hand over 48 months. All participants received secukinumab treatment and were followed up according to clinical practice, with repeated HR-pQCT and MRI. Number and volume of erosions, bone density, cortical and trabecular microarchitecture and bone biomechanical properties were assessed based on HR-pQCT scans. MRI synovitis, tenosynovitis, osteitis, periarticular inflammation, erosions and osteoproliferation were quantified by Psoriatic Arthritis MRI Score (PsAMRIS)-Outcome Measures in Rheumatology (OMERACT) score. Study outcomes included drug survival and changes from baseline in disease activity, functional status and imaging-detected inflammation and damage.Results32 patients with PsA (40.6% female, mean age 56±7.5 years) were enrolled. Drug survival rate was 68.8% at 48 months. Secukinumab was highly effective in all PsA disease domains, with significant improvements in Disease Activity Score 28 (p<0.001), Leeds Enthesitis Index (p=0.027), Psoriasis Area and Severity Index (p=0.001), C reactive protein (p=0.09), Psoriatic Arthritis Impact of Disease (p<0.001) and pain (p<0.001). Functional status measured by the Health Assessment Questionnaire remained stable. On HR-pQCT, bone density, microarchitecture and biomechanics were preserved. There was no progression of bone erosions (all changes were not significant). On MRI, PsAMRIS erosion and osteoproliferation subitems increased marginally (+1.4 and +0.8, respectively), while inflammatory changes remained stably low. No major safety signals emerged.ConclusionMultimodal imaging with HR-pQCT and MRI showed no relevant progression of structural bone damage over 48 months in patients with PsA treated with secukinumab, suggesting that anti-IL-17A therapy induces sustained osteoprotective effects in PsA.Weiterlesen