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BackgroundPsoriatic arthritis (PsA) is an immune-mediated chronic inflammatory disease that causes chronic pain, psychological problems, and a significant economic burden, and therefore must be diagnosed and treated early. Existing treatments have limited efficacy and side effects. The study aimed to identify potential drug targets associated with psoriatic arthritis through proteomics and Mendelian randomization (MR) analysis.Materials and methodsLarge-scale genome-wide association studies and proteomics data were used to assess the causal relationship between plasma proteins and PsA through MR analysis, Bayesian colocalization analysis, summary data-based Mendelian randomization (SMR) analysis, and heterogeneity in dependent instruments (HEIDI) test, and to analyze protein-protein interaction networks.ResultsThe study identified 26 proteins that may be causally related to PsA, of which 15 were positively correlated and 11 negatively correlated. According to the results of SMR analysis and colocalization analysis, these targets were further analyzed and classified into high, medium, and low confidence levels. High confidence targets include APOF, PRSS27, and DDX58, which were consistently supported by multiple analyses.ConclusionThe study identified several promising targets for the treatment of psoriatic arthritis through multiple analysis methods, providing a theoretical basis for future treatment strategies, but further experimental verification and clinical research are needed. Key Points • Using large-scale genome-wide association studies and proteomics data, drug targets for psoriatic arthritis (PsA) were identified through Mendelian randomization analysis, Bayesian colocalization analysis, and summary-data-based Mendelian randomization (SMR) analysis. • The study identified 26 proteins that are causally related to psoriatic arthritis, of which 15 are positively and 11 are negatively associated with psoriatic arthritis. • Among the identified proteins, APOF, PRSS27, and DDX58 were ranked as high confidence targets.Weiterlesen

BackgroundThe correlation between psoriasis with individual cardiometabolic diseases (CMDs), including coronary heart disease (CHD), stroke, hypertension, heart failure (HF), and type 2 diabetes mellitus (T2DM), have yielded conflicting results, and genetic susceptibility's role in modifying these relationships remains unexplored.ObjectiveTo investigate the association of psoriasis with the risk of CMDs, and to assess the modified effect of genetic susceptibility on these associations.MethodsA total of 390,165 participants from the UK Biobank cohort were enrolled. Cox proportional hazards models were used to examine the association between psoriasis and the incidence of CMDs. The genetic risk score for these diseases was incorporated as tertiles to assess potential effect modification in these association. The outcome was CMDs.ResultsDuring a median 12.0-year follow-up, a total of 23,811 incident CHD events, 6,941 HF, 82,963 hypertension, 6,902 stroke, and 16,788 T2DM were recorded. Participants with psoriasis had an increased risk of incident CHD (hazard ratio [HR] 1.11, 95% confidence interval [CI] 1.03-1.21), HF (HR 1.20, 95% CI 1.06-1.35), hypertension (HR 1.10, 95% CI 1.05-1.15), and T2DM (HR 1.22, 95% CI 1.11-1.34) compared to those without psoriasis. The adverse impact of psoriasis was pronounced among individuals with a high genetic predisposition. The elevated risk of CMDs associated with psoriasis may be partially explained by inflammation and dyslipidemia.ConclusionsPsoriasis was associated with the incidence of CMDs, particularly among individuals with higher genetic predisposition. Hence, our study emphasized the significance of preventing and managing CMDs among psoriasis patients, particularly those with high genetic risk.Weiterlesen

Etwa 2 bis 3 von 100 Menschen haben Psoriasis, also Schuppenflechte. Es gibt viele verschiedene Biologika, was die Auswahl schwer macht. In einer aktuellen Studie schnitten die IL-23p19-Hemmer besonders gut ab – sie wirken am längsten und sorgen für eine nachhaltige Besserung der Haut[4][5]. Außerdem haben sie ein gutes Sicherheitsprofil, also wenig Nebenwirkungen[4][5]. Wer also auf der Suche nach einer langfristigen Behandlung ist, könnte mit einem IL-23p19-Hemmer wie Risankizumab oder Tildrakizumab eine starke Option finden[1][4][5]. Originaltitel: Journal of the European Academy of Dermatology and Venereology | Wiley Online Library Link zur Quelle

# Neue Hoffnung für Menschen mit Psoriasis: Peptide zum Einnehmen Für Menschen mit Psoriasis oder Psoriasis-Arthritis könnte bald eine neue Behandlungsoption zur Verfügung stehen. Forschende entwickeln derzeit Peptide in Tablettenform zur Behandlung dieser entzündlichen Erkrankungen[1][3]. Bislang müssen viele Betroffene mit schwerer Psoriasis Spritzen bekommen. Diese enthalten Antikörper, die sehr gezielt gegen die Entzündung wirken. Zwar gibt es auch Tabletten, doch diese sind oft weniger wirksam oder verursachen stärkere Nebenwirkungen[5]. Die neuen oralen Peptide vereinen die Vorteile beider Welten. Sie wirken ähnlich gezielt wie die Antikörper-Spritzen, können aber einfach als Tablette eingenommen werden[1]. Ein vielversprechender Kandidat heißt Icotrokinra. Dieses Peptid blockiert den Entzündungsbotenstoff IL-23. In einer Studie mit Psoriasis-Patienten hat es bereits gute Ergebnisse gezeigt. Die Hautbeschwerden verbesserten sich deutlich und es traten kaum Nebenwirkungen auf[3]. Laufende Studien untersuchen jetzt, wie gut Icotrokinra bei Psoriasis-Arthritis und anderen entzündlichen Erkrankungen wirkt. Originaltitel: Oral Peptide Therapeutics as an Emerging Treatment Modality in Immune-Mediated Inflammatory Diseases: A Narrative Review. Link zur Quelle

Bei einer neuen Untersuchung mit moderner Bildgebung zeigte sich: Die Immunzellen in der Haut unterscheiden sich bei Schuppenflechte (Psoriasis) und Neurodermitis (atopische Dermatitis) stärker als gedacht. Besonders deutlich sind die Unterschiede bei Makrophagen und dendritischen Zellen. Bei Neurodermitis treten spezielle dendritische Zellen mit antiviralen Eigenschaften sowie eher "entspannte" Makrophagen auf. Bei Psoriasis finden sich dagegen mehr CD8+ T-Zellen direkt in der obersten Hautschicht. Diese feinen Unterschiede könnten helfen, neue Therapien gezielter zu entwickeln, weil sie typische Krankheitsmerkmale sichtbar machen[2]. Originaltitel: High content imaging shows distinct macrophage and dendritic cell phenotypes for psoriasis and atopic dermatitis. Link zur Quelle

Trial number: 2024-516213-20-00 Overall trial status: Ongoing, recruiting Trial title: A Phase 3, parallel-group, randomized, double-blind, 3-arm, placebo-controlled, multicenter study to investigate the efficacy and safety of subcutaneous sonelokimab in male and female participants aged 18 years and over with active psoriatic arthritis who are naive to biologic DMARDs Medical conditions: Psoriatic arthritis Status in each country: Hungary:Ongoing, recruiting, Romania:Ongoing, recruiting, Spain:Ongoing, recruiting, Greece:Authorised, recruitment pending, Latvia:Ongoing, recruiting, Lithuania:Ongoing, recruiting, Poland:Authorised, recruitment pending, Croatia:Authorised, recruiting, Czechia:Ongoing, recruiting, Finland:Ongoing, recruiting, Estonia:Ongoing, recruiting, France:Ongoing, recruiting, Slovakia:Ongoing, recruiting, Germany:Ongoing, recruiting, Bulgaria:Ongoing, recruiting, Portugal:Authorised, recruiting Trial phase: Therapeutic confirmatory (Phase III) Therapeutic Areas: Diseases [C] - Skin and Connective Tissue Diseases [C17] Primary end point: Proportion of participants achieving ACR50 (ie, ≥50% improvement on the ACR response criteria) at Week 16 Secondary end point: 1. Proportion of participants achieving ACR20 (ie, ≥20% improvement on the ACR response criteria) at Week 16, 2. Proportion of participants achieving Minimal Disease Activity (MDA) at Week 16, 3. Change from Baseline in Health Assessment Questionnaire—Disability Index (HAQ-DI) at Week 16, 4. Proportion of participants achieving a decrease of ≥90% in the Psoriasis Area and Severity Index (PASI90) response at Week 16 in the subgroup of participants with PsO involving ≥3% body surface area at Baseline, 5. Change from Baseline in SF-36 PCS at Week 16, 6. Change from Baseline to Week 16 in joint/bone structural damage (van der Heijde modified Total Sharp Score), 7. Incidence, relatedness, severity, and seriousness of TEAEs, 8. Withdrawal due to TEAEs, 9. Clinically relevant abnormalities in vital signs (blood pressure and heart rate) and body weight, 10. Clinically relevant abnormalities in 12-lead ECG variables, 11. Clinically relevant abnormalities in laboratory parameters (hematology, biochemistry, and urinalysis) Age of participants: 65+ years, 18-64 years Gender of participants: Female, Male Trial region: In both EEA and non-EEA Planned number of participants: 590 Sponsor: MoonLake Immunotherapeutics AG Sponsor type: Pharmaceutical company Trial product: Placebo is a sterile solution in a single use prefilled syringe (pfs) intended for subcutaneous administration, Sonelokimab Results posted: No Overall decision date: 10/03/2025 Countries decision date: BG: 12/03/2025, HR: 17/03/2025, CZ: 12/03/2025, EE: 17/03/2025, FR: 10/03/2025, HU: 14/03/2025, LV: 12/03/2025, LT: 13/03/2025, PT: 13/03/2025, ES: 11/03/2025, SK: 10/03/2025, FI: 21/03/2025, RO: 17/03/2025, PL: 26/03/2025, DE: 13/03/2025, GR: 11/03/2025 Last updated date: 30/05/2025Den kompletten Artikel zeigen

Trial number: 2024-516219-25-00 Overall trial status: Ongoing, recruiting Trial title: A Phase 3, parallel-group, randomized, double-blind, 4-arm, placebo-controlled, multicenter study with risankizumab as active reference arm, to investigate the efficacy and safety of subcutaneous sonelokimab in male and female participants aged 18 years and over with active psoriatic arthritis and previous inadequate response or intolerance to tumor necrosis factor-α inhibitors Medical conditions: psoriatic arthritis Status in each country: Spain:Ongoing, recruiting, Czechia:Ongoing, recruiting, Bulgaria:Ongoing, recruiting, Poland:Ongoing, recruiting, Hungary:Ongoing, recruiting, France:Authorised, recruiting, Germany:Ongoing, recruiting Trial phase: Therapeutic confirmatory (Phase III) Therapeutic Areas: Diseases [C] - Musculoskeletal Diseases [C05], Diseases [C] - Skin and Connective Tissue Diseases [C17] Primary end point: 1. Proportion of participants achieving ACR50 (ie, ≥50% response on the ACR response criteria) at Week 16 Secondary end point: 1. Proportion of participants achieving ACR20 (ie, ≥20% response on the ACR response criteria) at Week 16, 2. Proportion of participants achieving Minimal Disease Activity (MDA) at Week 16, 3. Change from Baseline in Health Assessment Questionnaire—Disability Index (HAQ-DI) at Week 16, 4. Proportion of participants achieving PASI90 response at Week 16 in the subset of participants with PsO involving ≥3% body surface area at Baseline, 5. Change from Baseline in SF-36 PCS at Week 16, 6. Proportion of participants achieving ACR50 at Week 16, 7. Incidence, relatedness, severity, and seriousness of TEAEs, 8. Withdrawal due to TEAEs, 9. Clinically relevant abnormalities in vital signs (blood pressure and heart rate) and body weight, 10. Clinically relevant abnormalities in 12-lead ECG variables, 11. Clinically relevant abnormalities in laboratory parameters (hematology, biochemistry, and urinalysis) Age of participants: 18-64 years, 65+ years Gender of participants: Female, Male Trial region: In both EEA and non-EEA Planned number of participants: 372 Sponsor: MoonLake Immunotherapeutics AG Sponsor type: Pharmaceutical company Trial product: Skyrizi 150 mg solution for injection in pre-filled syringe, Sonelokimab, Placebo is a sterile solution in a single use prefilled syringe (PFS) intended for subcutaneous administration., Sonelokimab Results posted: No Overall decision date: 07/03/2025 Countries decision date: BG: 12/03/2025, CZ: 11/03/2025, FR: 07/03/2025, DE: 10/03/2025, HU: 13/03/2025, ES: 10/03/2025, PL: 16/03/2025 Last updated date: 30/05/2025Den kompletten Artikel zeigen

Trial number: 2023-507193-40-00 Overall trial status: Authorised, recruiting Trial title: A Multicenter, Randomized, Double-Blind, Placebo and Active Comparator Controlled Phase 3 Study to Evaluate the Efficacy and Safety of ESK-001 in Patients with Moderate to Severe Plaque Psoriasis (ONWARD1) Medical conditions: Moderate to Severe Plaque Psoriasis Status in each country: Bulgaria:Ongoing, recruitment ended, Belgium:Authorised, recruiting, Portugal:Ongoing, recruitment ended, Poland:Ongoing, recruitment ended, Czechia:Ongoing, recruitment ended, Germany:Ongoing, recruitment ended Trial phase: Therapeutic confirmatory (Phase III) Therapeutic Areas: Diseases [C] - Skin and Connective Tissue Diseases [C17] Primary end point: Achievement of co-primary endpoint (PASI-75 & sPGA-0/1) at Week 16 compared with Placebo Secondary end point: Week 16 Endpoints: *Achievement of PASI-90, PASI-100, sPGA-0 PASI-75 and sPGA-0/1 compared to apremilast ss-PGA-0/1 PROs: PSSD-0 and DLQI-0/1 *Change from baseline in %BSA Pruritis NRS score, Week 24 Endpoints compared to apremilast: *Achievement of PASI-75, PASI-90, PASI-100 sPGA-0/1, sPGA-0 ss-PGA-0/1 PROs: PSSD-0 and DLQI-0/1 *Change from baseline %BSA Pruritis NRS score Age of participants: 18-64 years, 65+ years Gender of participants: Female, Male Trial region: In both EEA and non-EEA Planned number of participants: 389 Sponsor: Alumis Inc. Sponsor type: Pharmaceutical company Trial product: Otezla 10mg, 20mg, 30 mg film-coated tablets, Otezla 30 mg film-coated tablets, ESK-001, Name: ESK-001 placebo Pharmaceutical Form: film-coated tablet Route of administration: Oral use Maximum duration of treatment: 16 weeks, Name: apremilast placebo Pharmaceutical form: Only over-encapsulating capsule shell containing backfill, no tablet Route of administration: oral use Maximum duration of treatment: 16 weeks, Otezla 30 mg film-coated tablets Results posted: No Overall decision date: 10/12/2024 Countries decision date: BE: 10/12/2024, DE: 10/12/2024, CZ: 11/12/2024, PT: 11/12/2024, BG: 16/12/2024, PL: 16/12/2024 Last updated date: 11/03/2025Den kompletten Artikel zeigen

# IL-23-Hemmer: Die Langzeitlösung bei Psoriasis? Gute Nachrichten für alle mit Schuppenflechte! Etwa 2-3% der Bevölkerung leben mit Psoriasis. Bei der Behandlung stehen heute viele biologische Wirkstoffe zur Auswahl. Das kann die Therapieentscheidung schwierig machen. Eine aktuelle Studie zeigt jetzt: Medikamente, die gezielt den Botenstoff IL-23p19 blockieren, wirken besonders lange. Diese sogenannten IL-23p19-Hemmer erreichen bei vielen Betroffenen eine komplette Hautklärung. Die Erfolgsquote liegt bei beeindruckenden 50-70%[3]. Zu diesen Wirkstoffen gehört zum Beispiel Risankizumab. Klinische Studien bestätigen seine hohe Wirksamkeit und gute Verträglichkeit[5]. Eine weitere Studie zeigt, dass Tildrakizumab über fünf Jahre hinweg gute Ergebnisse liefert[1]. Die Behandlung normalisiert nicht nur die Hautoberfläche, sondern reduziert auch Entzündungsprozesse und verbessert die Hautstruktur von innen heraus[2]. Für Menschen mit mittelschwerer bis schwerer Schuppenflechte stellen IL-23p19-Hemmer damit eine vielversprechende Therapieoption mit langanhaltender Wirkung dar[4]. Originaltitel: emJournal of the European Academy of Dermatology and Venereology/em | Wiley Online Library Link zur Quelle

Viele neue Medikamente für Psoriasis wurden in den letzten Jahren direkt miteinander verglichen. Biologika, zum Beispiel Secukinumab, Guselkumab und Risankizumab, wirken deutlich besser als ältere Mittel wie Adalimumab oder Etanercept. Besonders Mittel, die auf IL-17 oder IL-23 zielen, führen häufiger zu fast komplett erscheinungsfreier Haut. Bei den Tabletten sticht Deucravacitinib heraus, es ist wirksamer als Apremilast. Die Sicherheit ist bei allen ähnlich, aber IL-17-Mittel machen öfter Pilzinfektionen. Insgesamt schneiden neue Biologika am besten ab, aber moderne Tabletten sind eine gute Alternative, besonders wenn man es lieber einfach mag[1][2][5]. Originaltitel: Systematic review of comparative studies on emerging psoriasis treatments: comparing biologics with biologics, small molecule inhibitors with small molecule inhibitors, and biologics with small molecule inhibitors - Inflammopharmacology Link zur Quelle

Eine große Studie aus Schweden und Deutschland hat untersucht, wie Menschen mit Psoriasis-Arthritis (PsA) und axialer Spondyloarthritis (axSpA) moderne Medikamente nutzen. Die meisten Patienten waren noch nie mit diesen Wirkstoffen behandelt worden, viele hatten aber schon andere Medikamente ausprobiert. In Schweden waren die Patienten meist jünger und hatten weniger Begleiterkrankungen als die in Deutschland. Beliebtestes Mittel in beiden Ländern waren sogenannte TNF-Hemmer. Auffällig: In Deutschland wurden manche Medikamente, zum Beispiel Secukinumab oder Guselkumab, oft höher dosiert als in Schweden. Die Unterschiede spiegeln wohl verschiedene Bedürfnisse und Begleiterkrankungen wider. Das zeigt: Bei der Behandlung zählt oft die individuelle Situation[1][2]. Originaltitel: Trace Element Deficiency in Axial Spondyloarthritis and Psoriatic Arthritis in Relation to Markers of Inflammation and Remission. Link zur Quelle

Thermalwasser und Balneotherapie sind bei Hautkrankheiten wie Psoriasis, Neurodermitis oder Akne beliebt. Sie wirken entzündungshemmend und antioxidativ und können laut aktuellen Studien tatsächlich Symptome lindern[2][4]. Vor allem Schwefelwasser zeigt gute Effekte bei Psoriasis und anderen Hautkrankheiten[3]. Thermalwasser wird auch in Kosmetikprodukten für feuchtere, glattere Haut verwendet. Aber: Man weiß noch nicht genau, wie Thermalwasser eigentlich wirkt, und welche Inhaltsstoffe besonders helfen. Es braucht weitere Studien, um optimale Behandlungen festzulegen und die langfristige Wirkung zu prüfen[4][5]. Bis dahin bleibt Thermalwasser eine spannende, aber nicht alleinige Lösung. Originaltitel: Comprehensive review of dermatological and cosmeceutical manifestations of thermal water and future insights - International Journal of Biometeorology Link zur Quelle

Conditions: Plaque Psoriasis Interventions: Drug: Deucravacitinib; Other: Placebo Sponsors: Bristol-Myers Squibb Not yet recruitingDen kompletten Artikel zeigen

Trial number: 2022-502361-15-00 Overall trial status: Ongoing, recruitment ended Trial title: An Open-Label, Multi-Center Extension Study to Characterize the Long-Term Safety and Efficacy of BMS-986165 in Subjects with Moderate-to-Severe Plaque Psoriasis Medical conditions: Moderate-to-Severe Plaque Psoriasis Status in each country: Hungary:Ongoing, recruitment ended, Germany:Ongoing, recruitment ended, Sweden:Ongoing, recruitment ended, France:Ongoing, recruitment ended, Poland:Ongoing, recruitment ended, Finland:Ongoing, recruitment ended, Spain:Ongoing, recruitment ended, Czechia:Ongoing, recruitment ended Trial phase: Therapeutic confirmatory (Phase III) Therapeutic Areas: Diseases [C] - Skin and Connective Tissue Diseases [C17] Primary end point: Adverse events and serious adverse events Secondary end point: sPGA 0/1 response, PASI 75 response Age of participants: 65+ years, 18-64 years Gender of participants: Female, Male Trial region: In both EEA and non-EEA Planned number of participants: 664 Sponsor: Bristol Myers Squibb International Corporation Sponsor type: Pharmaceutical company Trial product: Placebo to match BMS 986165 tablet, deucravacitinib Results posted: No Overall decision date: 05/04/2024 Countries decision date: FR: 21/05/2024, HU: 05/04/2024, PL: 12/04/2024, CZ: 09/04/2024, ES: 09/04/2024, FI: 09/04/2024, SE: 05/04/2024, DE: 10/04/2024 Last updated date: 27/05/2025Den kompletten Artikel zeigen

Trial number: 2022-501362-22-00 Overall trial status: Ended Trial title: 22104: A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 2b/3 Study to Evaluate the Efficacy and Safety of Izokibep in Subjects with Active Psoriatic Arthritis Medical conditions: Psoriatic Arthritis Status in each country: Hungary:Ended, Czechia:Ended, Poland:Ended, Spain:Ended, Germany:Ended, Bulgaria:Ended Trial phase: Phase II and Phase III (Integrated) Therapeutic Areas: Diseases [C] - Musculoskeletal Diseases [C05] Primary end point: ACR50 at Week 16 Secondary end point: • Resolution of enthesitis (LEI = 0) at Week 16 • PsAID response at Week 16 • PASI90 at Week 16 • HAQ-DI change from baseline to Week 16 • ACR20 at Week 16 • TEAEs, events of interest, and SAEs • Laboratory values and vital signs at collected timepoints • Treatment-emergent ADAs Age of participants: 18-64 years, 65+ years Gender of participants: Female, Male Trial region: In both EEA and non-EEA Planned number of participants: 78 Sponsor: Acelyrin Inc., Acelyrin Inc. Sponsor type: Pharmaceutical company, Pharmaceutical company Trial product: Izokibep, Placebo Results posted: Yes Overall decision date: 29/03/2023 Countries decision date: PL: 03/04/2023, DE: 29/03/2023, HU: 30/03/2023, ES: 03/04/2023, CZ: 30/03/2023, BG: 03/04/2023 Last updated date: 16/10/2024Den kompletten Artikel zeigen