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**Hauterkrankungen und Psyche: Was Psoriasis und Vitiligo verbindet** Menschen mit Hauterkrankungen kämpfen oft mit mehr als nur den sichtbaren Symptomen. Eine neue deutsche Studie zeigt jetzt, wie häufig psychische Probleme bei verschiedenen Hautkrankheiten auftreten[1]. Forscher haben Daten von fast 3 Millionen Versicherten analysiert. Sie verglichen Menschen mit Vitiligo mit Psoriasis-Patienten und anderen Gruppen[1]. Das Ergebnis ist wichtig für Sie: Menschen mit Vitiligo haben deutlich mehr Angststörungen und Depressionen als Psoriasis-Patienten. Bei Vitiligo treten diese psychischen Probleme etwa 2 bis 3 Mal häufiger auf[1]. Aber auch bei Psoriasis ist die psychische Belastung hoch. Weltweit berichten über 58 Prozent der Patienten von Depressionen oder Angst[2]. Viele vermeiden soziale Kontakte oder fühlen sich weniger selbstbewusst[2]. Die gute Nachricht: Experten fordern jetzt bessere psychologische Unterstützung für alle Patienten mit sichtbaren Hauterkrankungen. Das bedeutet, dass Ärzte künftig nicht nur die Haut, sondern auch die Psyche behandeln sollten[1][2]. Wenn Sie mit Psoriasis kämpfen und sich niedergeschlagen fühlen, sprechen Sie mit Ihrem Arzt. Psychologische Hilfe ist genauso wichtig wie Hautbehandlungen. Originaltitel: Prevalence and comparative risk of mental health disorders in persons with vitiligo: a retrospective matched cohort study using claims data with expert-informed case validation. Link zur Quelle

# Wenn die Haut leidet, leidet auch die Seele Menschen mit Schuppenflechte, Neurodermitis oder Hidradenitis suppurativa brauchen nicht nur eine gute Hautbehandlung. Sie benötigen auch psychologische Unterstützung. Das zeigt jetzt eine große internationale Studie mit insgesamt über eine Million Patienten.[1] Die Forschung hat ergeben: Patienten mit diesen Hauterkrankungen suchen deutlich häufiger psychologische Hilfe auf als gesunde Menschen. Bei Neurodermitis ist der Anstieg besonders groß. Diese Patienten gehen etwa dreimal häufiger zur Psychotherapie als Kontrollpersonen ohne Hauterkrankung.[1] **Aber warum ist das so?** Die chronischen Hautleiden verändern die Lebensqualität stark. Sichtbare Flecken und Ausschläge belasten viele Menschen emotional. Manche entwickeln Depressionen oder Angststörungen.[3] Zudem beeinflussen die Entzündungsprozesse in der Haut auch das Nervensystem und können Stimmung und Psyche belasten.[3] Interessant: Männer und Frauen sind unterschiedlich betroffen. Bei Neurodermitis leiden Frauen stärker unter psychischen Belastungen. Bei Schuppenflechte ist es etwas ausgewogener verteilt.[1] **Das Fazit der Studie:** Ärzte sollten Haut- und Seelenpflege gemeinsam angehen. Wer regelmäßig zur Hauttherapeut geht, sollte auch ein offenes Ohr für psychische Belastungen haben. Psychologische Hilfe gehört zur modernen Behandlung einfach dazu. Originaltitel: Psychiatric and Psychological Approach in Patients with Atopic Dermatitis, Hidradenitis Suppurativa and Psoriasis: A Propensity-Matched Real-World Cohort Study. Link zur Quelle

Originaltitel: Psychiatric and Psychological Approach in Patients with Atopic Dermatitis, Hidradenitis Suppurativa and Psoriasis: A Propensity-Matched Real-World Cohort Study - Dermatology and Therapy Link zur Quelle

Originaltitel: Editorial: Advancements in AI for the analysis and interpretation of large-scale data by omics techniques. Link zur Quelle

Originaltitel: Joint Assessment Matters: Diagnostic and Therapeutic Benefits of Interdisciplinary Psoriasis Care - Advances in Therapy Link zur Quelle

Originaltitel: Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch Link zur Quelle

# Magnesium: Das Wundermittel für deine Haut? Magnesium könnte für Menschen mit Psoriasis interessant sein. Der Mineralstoff hilft deinem Körper bei über 300 verschiedenen Prozessen.[1] Besonders wichtig: Er wirkt entzündungshemmend.[1][2] Das ist gute Nachricht für dich. Denn Psoriasis entsteht durch Entzündungen in der Haut.[1] Magnesium kann diese Entzündungen beruhigen und Rötungen reduzieren.[1] Stress verschlimmert Psoriasis oft. Hier hilft Magnesium gleich doppelt. Es senkt den Stresshormon Cortisol in deinem Körper.[4] Gleichzeitig verbessert es deine Schlafqualität.[1] Besserer Schlaf bedeutet weniger Stress für deine Haut. Auch die Hautbarriere profitiert. Magnesium unterstützt die natürliche Feuchtigkeitsversorgung deiner Haut.[1][2] Das ist wichtig, weil Psoriasis die Haut austrocknet. Du kannst Magnesium auf zwei Wegen nutzen. Entweder nimmst du es als Nahrungsergänzung. Oder du verwendest Cremes und Öle mit Magnesium.[1][4] Studien zeigen: Magnesiumreiche Bäder (wie mit Totes-Meer-Salz) verbessern die Hautstruktur deutlich.[4] Sprich mit deinem Arzt, bevor du Magnesium nimmst. So findest ihr gemeinsam die beste Form für dich. Originaltitel: The role of magnesium in dermatology Link zur Quelle

Originaltitel: Joint Assessment Matters: Diagnostic and Therapeutic Benefits of Interdisciplinary Psoriasis Care. Link zur Quelle

BackgroundSkin is the largest organ of the human body. It continuously encounters environmental toxicants, including airborne pollutants, which may induce many skin disorders, such as psoriasis. However, evidence on the association between airborne pollutants and psoriasis prevalence in China remains limited.MethodsWe used nationwide inpatient diagnostic data on psoriasis from 2021 to 2023, encompassing 149 744 cases across 31 provinces, municipalities, and autonomous regions in China, along with corresponding air pollution data. We analysed the spatial distribution and clustering patterns of psoriasis using the spatial autocorrelation analysis. We employed Pearson correlation analysis and Geodetector to explore the spatial heterogeneity of psoriasis and its association with airborne pollutants at the provincial level. We assessed the explanatory power of individual airborne pollutants and their combined effects on psoriasis prevalence.ResultsPearson correlation analysis revealed that PM10 (r = 0.604), PM2.5 (r = 0.429), air quality index (AQI) (r = 0.542), and NO2 (r = 0.476) have significant positive correlations with psoriasis prevalence. Psoriasis and its subtypes exhibited significant spatial heterogeneity and diverse clustering patterns across regions. Geodetector identified PM10 (q = 0.357; P = 0.000), AQI (q = 0.315; P = 0.000), and O3 (q = 0.264; P = 0.000) as key contributors to this spatial heterogeneity. Interactive detection analysis further revealed that the combined effects of specific pollutant pairs, including PM2.5 and SO2 (q = 0.790), PM10 and SO2 (q = 0.727), as well as O3 and SO2 (q = 0.704), played a pivotal role in explaining the prevalence of psoriasis. The other combinations also showed an important impact on psoriasis subtypes, including psoriasis vulgaris (PM2.5 and SO2) (q = 0.792), psoriasis erythematous (PM2.5 and SO2) (q = 0.852), psoriatic arthritis (PM10 and O3) (q = 0.840), and nail psoriasis (PM10 and O3) (q = 0.789).ConclusionsThe airborne pollutants influence psoriasis prevalence and its subtypes. With the largest global study of the Asian population, we provide novel insights into the impact of air pollution on psoriasis, guiding future public health policies and clinical interventions.Weiterlesen

No abstract supplied.Weiterlesen

No abstract supplied.Weiterlesen

IntroductionBiologic therapies have transformed the management of moderate-to-severe psoriasis but are associated with long-term treatment burden and substantial healthcare costs. Dose spacing, defined as extending dosing intervals in patients with controlled disease, has emerged as a potential optimization strategy. However, data on real-world implementation and clinician perspectives remain limited.MethodsWe conducted a national, cross-sectional survey among Portuguese dermatologists experienced in prescribing biologic therapies for psoriasis. An anonymous, web-based questionnaire assessed clinicians' perspectives and real-world practices regarding biologic dose spacing, including eligibility criteria, preferred biologic classes, implementation strategies, outcomes after loss of disease control, and limiting clinical factors.ResultsSeventy-five dermatologists completed the survey (response rate 48.4%). All respondents considered dose spacing feasible. The most frequently cited eligibility criteria were absolute Psoriasis Area and Severity Index (PASI) ≤ 1, body surface area (BSA) ≤ 1%, and a 90% improvement in PASI (PASI 90). Interleukin-23 (IL-23) inhibitors were perceived as the most suitable class for dose spacing (93.3%). In routine practice, dose spacing was applied frequently by 30.7% of respondents and occasionally by 48.0%. Most clinicians (69.3%) required more than 12 months of sustained disease control before initiating dose spacing, predominantly using progressive extension of dosing intervals (96.0%). IL-23 inhibitors were the biologics most frequently dose-spaced in current practice. Following loss of disease control, 86.7% reported successful recapture of response after reintroduction of standard dosing. The main factors limiting dose spacing were a history of difficult-to-control psoriasis (77.3%) and concomitant psoriatic arthritis (72.0%).ConclusionBiologic dose spacing is already integrated into clinical practice in Portugal. Further prospective studies are needed to establish standardized criteria and guide safe implementation.Weiterlesen

This cross-sectional study aimed to determine the detectability of a panel of 92 inflammatory biomarkers in tape strips from the skin of patients with inflammatory skin diseases, and whether this depended on the number of tape strips taken. Furthermore, the biomarker levels in the patients were compared with those in healthy controls. Eight consecutive uniform tape strips (each 3.8 cm²) were obtained from 2 adjacent skin sites from 8 atopic dermatitis, contact dermatitis, and psoriasis patients, respectively, and 5 controls. Three separate analyses were carried out using the Olink® Target Inflammation panel: (i) all 8 tape strips (1-8) from 1 skin site and from the other skin site, (ii) the first 4 tape strips (1-4), and (iii) the next 4 tape strips (5-8). Biomarkers were above the detection limit for 65.7% of atopic dermatitis, 70.2% of psoriasis, and 45.1% of contact dermatitis samples. There were no significant differences in biomarker levels between the use of 4 or 8 tape strips, or between the first and last 4 tape strips. In general, atopic dermatitis and psoriasis patients were distinguishable from controls, whereas contact dermatitis patients were not. Based on the overall data quality, analysing protein signatures in tape strips with the targeted inflammatory panel is feasible.Weiterlesen

Photosensitive presentations of psoriasis are often under-recognized and may closely mimic other photodistributed dermatoses. We report the case of a 39-year-old male patient with no history of other photodermatoses who developed a progressive, non-pruritic rash, localized in sun-exposed skin areas, with marked exacerbation after phototherapy. Pronounced photosensitivity and atypical lesion distribution, involving the malar and nasal regions, complicated the initial differential diagnosis between photosensitive plaque psoriasis and cutaneous lupus erythematosus (CLE). Only further clinical evaluation, alongside histopathological analysis and immunological testing, helped to confirm the final diagnosis of photosensitive plaque psoriasis. Treatment with systemic and topical corticosteroids, vitamin D analogues, and calcineurin inhibitors resulted in gradual clinical improvement. This case report highlights photosensitive psoriasis as an important cause of photodistributed eruptions and a rare but significant mimic of CLE.Weiterlesen

ObjectiveTo evaluate the long-term efficacy of interleukin (IL)-17A inhibition with secukinumab on structural bone changes and clinical outcomes in psoriatic arthritis (PsA).MethodsWe conducted a phase-IV non-interventional study on adult patients with active PsA using high-resolution peripheral quantitative CT (HR-pQCT) and MRI of the hand over 48 months. All participants received secukinumab treatment and were followed up according to clinical practice, with repeated HR-pQCT and MRI. Number and volume of erosions, bone density, cortical and trabecular microarchitecture and bone biomechanical properties were assessed based on HR-pQCT scans. MRI synovitis, tenosynovitis, osteitis, periarticular inflammation, erosions and osteoproliferation were quantified by Psoriatic Arthritis MRI Score (PsAMRIS)-Outcome Measures in Rheumatology (OMERACT) score. Study outcomes included drug survival and changes from baseline in disease activity, functional status and imaging-detected inflammation and damage.Results32 patients with PsA (40.6% female, mean age 56±7.5 years) were enrolled. Drug survival rate was 68.8% at 48 months. Secukinumab was highly effective in all PsA disease domains, with significant improvements in Disease Activity Score 28 (p<0.001), Leeds Enthesitis Index (p=0.027), Psoriasis Area and Severity Index (p=0.001), C reactive protein (p=0.09), Psoriatic Arthritis Impact of Disease (p<0.001) and pain (p<0.001). Functional status measured by the Health Assessment Questionnaire remained stable. On HR-pQCT, bone density, microarchitecture and biomechanics were preserved. There was no progression of bone erosions (all changes were not significant). On MRI, PsAMRIS erosion and osteoproliferation subitems increased marginally (+1.4 and +0.8, respectively), while inflammatory changes remained stably low. No major safety signals emerged.ConclusionMultimodal imaging with HR-pQCT and MRI showed no relevant progression of structural bone damage over 48 months in patients with PsA treated with secukinumab, suggesting that anti-IL-17A therapy induces sustained osteoprotective effects in PsA.Weiterlesen

Background: Psoriasis is a chronic systemic inflammatory disease with established extra-cutaneous manifestations. While the association between uveitis and spondyloarthritis (SpA)-related disorders is well recognized, the incident risk of uveitis among broader psoriasis populations remains inadequately defined due to methodological limitations and inconsistent findings across previous studies. We aimed to estimate the incidence of uveitis in a large, nationwide population-based cohort and identify specific clinical and treatment-related predictors of ocular inflammation. Methods: This retrospective cohort study utilised electronic health records from Clalit Health Services, Israel's largest health maintenance organization (2002-2024). We identified 157,360 patients with dermatologist-confirmed psoriasis and 156,927 age- and sex-matched controls. The primary outcome was incident uveitis, with risk estimated using Cox proportional hazards models. Within the psoriasis cohort, multivariable logistic regression was employed to identify predictors of uveitis, ensuring appropriate temporal sequencing between psoriasis treatment exposure and outcome. Results: Over a median follow-up of 12.6 years, psoriasis was associated with a significantly higher risk of incident uveitis (adjusted Hazard Ratio [aHR] 1.80; 95% CI, 1.50-2.15). Stratified analysis revealed a graded risk pattern: mild psoriasis showed no increased risk (aHR 1.01; 95% CI, 0.91-1.13), whereas severe disease (aHR 1.59; 95% CI, 1.25-2.03) and concomitant SpA (aHR 2.21; 95% CI, 1.87-2.61) demonstrated markedly elevated risks. Within the psoriasis cohort, independent predictors included SpA, diabetes mellitus, systemic lupus erythematosus, and sarcoidosis. Exposure to biologics, particularly etanercept (OR 3.37; 95% CI, 2.42-4.54), was associated with higher odds of uveitis, potentially reflecting higher disease severity. Conclusions: Incident uveitis risk in psoriasis is primarily driven by the magnitude of systemic inflammatory burden, with the highest risk observed in severe disease and those with concomitant SpA. Clinicians should maintain heightened vigilance for ocular symptoms in these high-risk subgroups to ensure timely intervention.Weiterlesen

No abstract supplied.Weiterlesen

Psoriasis is a chronic, inflammatory skin disease occurring worldwide that significantly affects patients' quality of life. This common skin condition is characterized by abnormal hyperplasia of keratinocytes, which leads to the formation of raised, scaly plaques, typically located on the head, elbows, knees, and lumbar region. Psoriasis usually requires long-term drug therapy, which aims not only to combat skin symptoms but also to improve quality of life. Although topical treatments, systemic treatments (methotrexate, cyclosporine, acitretin), and phototherapy play a role, biologic agents have improved the efficacy of treatment of moderate-to-severe psoriasis. The purpose of this article is to comprehensively review the clinical trial data and evaluate and compare the key features of the currently approved biologic drugs for the treatment of psoriasis.Weiterlesen

Originaltitel: Antagonizing IL-17A Reduces Vascular Inflammation and Attenuates Oxidative Stress Formation but Does Not Significantly Improve Vascular Dysfunction Induced by One Week of Angiotensin II Treatment. Link zur Quelle

# Secukinumab schützt die Knochen bei Psoriasis-Arthritis Eine neue Studie zeigt: Das Medikament Secukinumab hält die Knochen bei Psoriasis-Arthritis stabil und verhindert Schäden langfristig. Forscher untersuchten dafür 32 Patienten über vier Jahre hinweg. Die Patienten bekamen regelmäßig spezielle Aufnahmen ihrer Hände gemacht. Diese zeigten sehr deutlich, wie es ihren Knochen geht. Das Ergebnis ist ermutigend: Die Knochendichte blieb erhalten. Es bildeten sich kaum neue Erosionen, also keine Löcher und Unebenheiten in den Knochen. Gleichzeitig verbesserte sich der Zustand der Patienten deutlich. Die Entzündungen gingen zurück. Die Schmerzen sanken. Die Patienten konnten ihre Hände besser bewegen. Zwei Drittel der Patienten setzten das Medikament über die ganze Zeit fort. Die Studie zeigt: Secukinumab wirkt nicht nur gegen Schmerzen und Entzündungen. Es schützt auch die Knochenstruktur. Das ist wichtig, weil Psoriasis-Arthritis die Knochen langfristig zerstören kann. Mit dem richtigen Medikament lässt sich diese Zerstörung verhindern. Originaltitel: Long-term osteoprotective effects of IL-17A blockade with secukinumab in psoriatic arthritis: data from the PSARTROS-II study Link zur Quelle

**Secukinumab schützt Knochen bei Psoriasis-Arthritis langfristig** Das Medikament Secukinumab hemmt einen Botenstoff namens IL-17A und schützt die Knochen von Menschen mit Psoriasis-Arthritis dauerhaft. Das zeigt die PSARTROS-II-Studie über vier Jahre hinweg. Die Ärzte beobachteten 32 Patienten und stellten mit speziellen Kameras fest: Die Knochen wurden nicht angegriffen. Sie blieben stabil und dicht. Die gefürchteten Knochenerosionen (kleine Löcher im Knochen) schritten nicht voran. Auch Entzündungen blieben dauerhaft niedrig. Das Wichtigste: Den Patienten ging es deutlich besser. Ihre Gelenkschmerzen sanken. Sie konnten besser laufen und arbeiten. Bei etwa 69 Prozent der Patienten wirkte das Mittel nach vier Jahren immer noch. Diese Ergebnisse sind ermutigend. Denn Knochenabbau ist bei Psoriasis-Arthritis ein großes Problem. Er führt zu Behinderungen. Wenn Secukinumab das verhindert, können Menschen mit dieser Erkrankung länger aktiv und mobil bleiben. Originaltitel: Long-term osteoprotective effects of IL-17A blockade with secukinumab in psoriatic arthritis: data from the PSARTROS-II study. Link zur Quelle

No abstract supplied.Weiterlesen

BackgroundPsoriasis is a persistent, chronic autoimmune skin disease that affects around 2% of the global population. Conventional therapies often exhibit limited efficacy, systemic side effects, and poor patient compliance due to long-term treatment needs.Materials & methodsThis study focused to develop and optimize a sulfasalazine-loaded microemulsion (SSZ-ME) for topical delivery to enhance skin penetration and therapeutic efficacy in psoriasis. Pseudo-ternary phase diagrams were prepared to identify the optimal surfactant mixture, with Tween 80 and Polyethylene Glycol 400 selected in a 2:1 ratio. A 23 factorial design was used to optimize formulation parameters, focusing on oil and surfactant mixture effects on globule size and viscosity.Results and conclusionsThe resulting microemulsions showed globule sizes between 60 ± 0.42 to 349 ± 0.13 nm, with optimal viscosity. In vitro release studies confirmed sustained drug release over 24 hours, following first-order kinetics. Skin permeation studies demonstrated enhanced drug penetration with SSZ-ME, while histopathological analysis revealed significant improvements in psoriatic symptoms in mice treated with 4% SSZ-ME compared to 2% SSZ-ME and marketed formulation. Blood analysis confirmed minimal systemic absorption and localized action. These results suggest that SSZ-ME offers a promising, patient-compliant, and effective topical therapy for psoriasis with improved therapeutic outcomes and minimal systemic exposure.Weiterlesen

# Model-informed Precision Dosing: Medikamente endlich richtig dosieren Lange Zeit bekamen alle Psoriasis-Patienten die gleiche Medikamentenmenge. Das ist aber nicht ideal, denn jeder Körper baut Medikamente unterschiedlich ab.[1] Ein neuer Ansatz könnte das ändern: Model-informed Precision Dosing, kurz MIPD. Mit MIPD können Ärzte vorhersagen, wie dein Körper ein Medikament verarbeitet.[1] Sie nutzen dafür Blutuntersuchungen und mathematische Modelle. So erkennen sie, welche Dosierung bei dir persönlich am besten passt. Die Vorteile sind überzeugend. Besserer Behandlungserfolg. Weniger Nebenwirkungen. Und die Medikamente wirken länger gut.[1] Eine Studie mit Psoriasis-Patienten zeigte: Etwa 35 Prozent bräuchten eine höhere Dosis als üblich. 26 Prozent könnten mit weniger auskommen.[2] Das spart Kosten und schont den Körper. Für dich als Patient bedeutet das neue Chancen. Bald könnten Behandlungen viel genauer auf deine Bedürfnisse abgestimmt sein. [1][2] Originaltitel: Bridging theory and practice in model-informed precision dosing of medication in inflammatory skin diseases Link zur Quelle

The aggregate index of systemic inflammation (AISI), calculated from monocyte, neutrophil, lymphocyte, and platelet counts, is a blood-count-derived composite marker of systemic inflammation. This cross-sectional study aimed to examine the association between AISI and the prevalence of psoriasis among U.S. adults. The dataset was obtained from the National Health and Nutrition Examination Survey (NHANES) database from 2003 to 2006 and from 2009 to 2014. The relevant covariates were adjusted during the analysis. We employed restricted cubic spline (RCS) regression and logistic regression frameworks to statistically assess the correlation between the AISI standard and psoriasis. The study also included subgroup analyses to determine whether the effectiveness of AISI varied among different categories. Compared with individuals without psoriasis, participants with psoriasis had higher AISI values. A total of 17 776 participants were included in the analysis. In multivariable logistic regression analyses, higher AISI levels were independently associated with higher odds of prevalent psoriasis after adjustment for potential confounders (p for trend < 0.001). Restricted cubic spline analyses demonstrated an approximately linear positive association between ln-transformed AISI and psoriasis prevalence (p for non-linearity > 0.05). Subgroup analyses showed no statistically significant interactions across most strata, suggesting overall consistency of the association. Receiver operating characteristic analysis indicated that AISI had limited discriminatory ability for prevalent psoriasis, with an AUC (95% CI) of 0.58 (0.55-0.60). In this large, population-based cross-sectional study, higher AISI levels were associated with the prevalence of psoriasis among U.S. adults. Given the cross-sectional design and the modest discriminatory ability (AUC = 0.58), AISI is best interpreted as a correlate of systemic inflammation rather than as a marker with predictive or causal utility for psoriasis.Weiterlesen